Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma—a systematic review
BackgroundHead and neck squamous cell carcinoma (HNSCC) is a group of heterogeneous malignancies and constitutes one of the most prevalent forms of cancer. Oral metronomic chemotherapy (OMCT) is a treatment in which low doses of anticancer drugs are given at regular intervals over a long time, with...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2025.1632316/full |
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| author | Aardra Binithadas Segin Chandran Deepak Pandiar Reshma Poothakulath Krishnan Divya Gopinath Divya Gopinath |
| author_facet | Aardra Binithadas Segin Chandran Deepak Pandiar Reshma Poothakulath Krishnan Divya Gopinath Divya Gopinath |
| author_sort | Aardra Binithadas Segin Chandran |
| collection | DOAJ |
| description | BackgroundHead and neck squamous cell carcinoma (HNSCC) is a group of heterogeneous malignancies and constitutes one of the most prevalent forms of cancer. Oral metronomic chemotherapy (OMCT) is a treatment in which low doses of anticancer drugs are given at regular intervals over a long time, with many advantages over conventional therapies, particularly in nations with high cancer burden. The present systematic review aimed to evaluate the efficacy of OMCT in the management of HNSCC in comparison to other standard chemotherapy regimens. Methodology: The review was registered in the Prospero database (CRD42023426000). An electronic search was conducted using PubMed, Scopus, Web of Science and Google Scholar databases. Articles in which OMCT was used to treat HNSCC were included for systematic review, and the survival and response rates were analyzed.ResultsTwenty-four eligible articles were included for evaluation, which revealed that administration of OMCT produced higher survival and response rates in subjects compared to standard chemotherapy.ConclusionThe evidence from the included studies supports that oral metronomic chemotherapy is substantially more effective as compared to standard chemotherapy regimens in squamous cell carcinomas of the head and neck.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42023426000, identifier (CRD42023426000). |
| format | Article |
| id | doaj-art-72d0051979664d0fa40e83539c6c26f1 |
| institution | DOAJ |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj-art-72d0051979664d0fa40e83539c6c26f12025-08-20T03:09:35ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-07-01610.3389/froh.2025.16323161632316Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma—a systematic reviewAardra Binithadas Segin Chandran0Deepak Pandiar1Reshma Poothakulath Krishnan2Divya Gopinath3Divya Gopinath4Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IndiaDepartment of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IndiaDepartment of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IndiaCollege of Dentistry, Ajman University, Ajman, United Arab EmiratesCentre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesBackgroundHead and neck squamous cell carcinoma (HNSCC) is a group of heterogeneous malignancies and constitutes one of the most prevalent forms of cancer. Oral metronomic chemotherapy (OMCT) is a treatment in which low doses of anticancer drugs are given at regular intervals over a long time, with many advantages over conventional therapies, particularly in nations with high cancer burden. The present systematic review aimed to evaluate the efficacy of OMCT in the management of HNSCC in comparison to other standard chemotherapy regimens. Methodology: The review was registered in the Prospero database (CRD42023426000). An electronic search was conducted using PubMed, Scopus, Web of Science and Google Scholar databases. Articles in which OMCT was used to treat HNSCC were included for systematic review, and the survival and response rates were analyzed.ResultsTwenty-four eligible articles were included for evaluation, which revealed that administration of OMCT produced higher survival and response rates in subjects compared to standard chemotherapy.ConclusionThe evidence from the included studies supports that oral metronomic chemotherapy is substantially more effective as compared to standard chemotherapy regimens in squamous cell carcinomas of the head and neck.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42023426000, identifier (CRD42023426000).https://www.frontiersin.org/articles/10.3389/froh.2025.1632316/fulloral metronomic chemotherapyhead and neck squamous cell carcinomasurvival rateangiogenesisOSCC (oral squamous cell carcinoma) |
| spellingShingle | Aardra Binithadas Segin Chandran Deepak Pandiar Reshma Poothakulath Krishnan Divya Gopinath Divya Gopinath Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma—a systematic review Frontiers in Oral Health oral metronomic chemotherapy head and neck squamous cell carcinoma survival rate angiogenesis OSCC (oral squamous cell carcinoma) |
| title | Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma—a systematic review |
| title_full | Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma—a systematic review |
| title_fullStr | Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma—a systematic review |
| title_full_unstemmed | Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma—a systematic review |
| title_short | Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma—a systematic review |
| title_sort | efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma a systematic review |
| topic | oral metronomic chemotherapy head and neck squamous cell carcinoma survival rate angiogenesis OSCC (oral squamous cell carcinoma) |
| url | https://www.frontiersin.org/articles/10.3389/froh.2025.1632316/full |
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