Gastrodin reduces myocardial ischemia/reperfusion injury via transgelin2/CNPase-mediated apoptosis regulation

Gastrodin reduces myocardial ischemia/reperfusion injury via transgelin2/CNPase-mediated apoptosis regulation

BackgroundMyocardial ischemia-reperfusion injury (MIRI) frequently occurs during rapid restoration of blood flow in the infarcted myocardium. While Gastrodin (GAS) mitigates MIRI, its mechanism requires further exploration.MethodsWe evaluated GAS effect in SD rats following 45-min left coronary arte...

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Bibliographic Details
Main Authors: Changyan Li, Peng Rao, Xiang Liu, Lin Yang, Yongliang Jiang, Gaosheng Yin, Shuangxiu Li, Ping Yang, Lin Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
myocardial ischemia/reperfusion injury
Gastrodin
apoptosis
CNPase
transgelin2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1604408/full
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