AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway
Abstract Obesity poses serious health risks and is trending younger, developing effective strategies to prevent obesity is crucial. Calcium intake is a potential strategy to reduce weight/fat, as it generally enhances the body’s energy metabolism. However, calcium’s effects on appetite and its speci...
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| Language: | English |
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BMC
2025-05-01
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| Series: | Cell & Bioscience |
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| Online Access: | https://doi.org/10.1186/s13578-025-01409-7 |
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| author | Aru Su Linghui Pan Qian Zhou Qin Zhu Ruihua Li Mingming Liu Ruifan Wu Lina Wang Songbo Wang Qingyan Jiang Gang Shu Canjun Zhu |
| author_facet | Aru Su Linghui Pan Qian Zhou Qin Zhu Ruihua Li Mingming Liu Ruifan Wu Lina Wang Songbo Wang Qingyan Jiang Gang Shu Canjun Zhu |
| author_sort | Aru Su |
| collection | DOAJ |
| description | Abstract Obesity poses serious health risks and is trending younger, developing effective strategies to prevent obesity is crucial. Calcium intake is a potential strategy to reduce weight/fat, as it generally enhances the body’s energy metabolism. However, calcium’s effects on appetite and its specific mechanisms remain unclear. To investigate these questions, we administered calcium orally to fasted mice and found that calcium inhibited food intake during the first 3 h. Long-term calcium supplementation in water decreased HFD intake, weight gain, and fat deposition while increasing energy metabolism in young mice. Mechanistically, calcium activated the vagal afferent nerves and inhibited ARCAgRP neurons—key appetite regulation neuron. What’s more, these effects are blunted by chemogenetic inhibition of gastrointestinal intestinal vagal afferent nerves or activation of ARCAgRP neuronal activity. Overall, we showed that ingested calcium activates vagal afferent nerves, inhibiting the activity of ARCAgRP neurons, thereby reducing food intake. This study supports calcium’s role in obesity dietary therapy. |
| format | Article |
| id | doaj-art-72cf13240ebd4c9ca8c6a1208c459cb0 |
| institution | OA Journals |
| issn | 2045-3701 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj-art-72cf13240ebd4c9ca8c6a1208c459cb02025-08-20T01:53:25ZengBMCCell & Bioscience2045-37012025-05-0115111210.1186/s13578-025-01409-7AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathwayAru Su0Linghui Pan1Qian Zhou2Qin Zhu3Ruihua Li4Mingming Liu5Ruifan Wu6Lina Wang7Songbo Wang8Qingyan Jiang9Gang Shu10Canjun Zhu11State Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural UniversityAbstract Obesity poses serious health risks and is trending younger, developing effective strategies to prevent obesity is crucial. Calcium intake is a potential strategy to reduce weight/fat, as it generally enhances the body’s energy metabolism. However, calcium’s effects on appetite and its specific mechanisms remain unclear. To investigate these questions, we administered calcium orally to fasted mice and found that calcium inhibited food intake during the first 3 h. Long-term calcium supplementation in water decreased HFD intake, weight gain, and fat deposition while increasing energy metabolism in young mice. Mechanistically, calcium activated the vagal afferent nerves and inhibited ARCAgRP neurons—key appetite regulation neuron. What’s more, these effects are blunted by chemogenetic inhibition of gastrointestinal intestinal vagal afferent nerves or activation of ARCAgRP neuronal activity. Overall, we showed that ingested calcium activates vagal afferent nerves, inhibiting the activity of ARCAgRP neurons, thereby reducing food intake. This study supports calcium’s role in obesity dietary therapy.https://doi.org/10.1186/s13578-025-01409-7CalciumAppetiteVagal afferent nerveAgRP |
| spellingShingle | Aru Su Linghui Pan Qian Zhou Qin Zhu Ruihua Li Mingming Liu Ruifan Wu Lina Wang Songbo Wang Qingyan Jiang Gang Shu Canjun Zhu AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway Cell & Bioscience Calcium Appetite Vagal afferent nerve AgRP |
| title | AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway |
| title_full | AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway |
| title_fullStr | AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway |
| title_full_unstemmed | AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway |
| title_short | AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway |
| title_sort | agrp mediated calcium inhibition of feeding via the vagal afferent nerve brain pathway |
| topic | Calcium Appetite Vagal afferent nerve AgRP |
| url | https://doi.org/10.1186/s13578-025-01409-7 |
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