Untargeted metabolic analysis using LC-Q-TOF-MS and toxicity assessment of Eryngium foetidum in zebrafish embryos
Toxicological studies of edible plant species are important to determine the safety of their consumption. Eryngium foetidum is an edible plant used in some countries for seasoning food and as a natural remedy in folk medicine. Despite this species’ gastronomic and medicinal properties, the chemical...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2025-03-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2025-0008 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849726170807926784 |
|---|---|
| author | Vázquez-Cancino Romario Rodríguez-Morales Sergio Jiménez-Pérez Nelly Del Carmen Peña-Morán Omar Aristeo Cerón-Romero Litzia Sánchez-Lombardo Irma Yair-Hidalgo Alam Ceronio Nancy Romero Alvarado-Sánchez Cuauhtémoc Hernández-Abreu Oswaldo |
| author_facet | Vázquez-Cancino Romario Rodríguez-Morales Sergio Jiménez-Pérez Nelly Del Carmen Peña-Morán Omar Aristeo Cerón-Romero Litzia Sánchez-Lombardo Irma Yair-Hidalgo Alam Ceronio Nancy Romero Alvarado-Sánchez Cuauhtémoc Hernández-Abreu Oswaldo |
| author_sort | Vázquez-Cancino Romario |
| collection | DOAJ |
| description | Toxicological studies of edible plant species are important to determine the safety of their consumption. Eryngium foetidum is an edible plant used in some countries for seasoning food and as a natural remedy in folk medicine. Despite this species’ gastronomic and medicinal properties, the chemical composition and toxicity have been unclear. The objective of our investigation was to determine the toxic potential of E. foetidum in the zebrafish embryo model and identify the potential compounds involved in its toxicity by electrospray ionization liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry. Acute exposure of zebrafish embryos to n-hexane extract produced higher toxicity than the other extracts in a time- and concentration-dependent fashion (coagulated embryo). A 96-h median lethal concentration (LC50) of 2.63 µg mL–1 (CI 95 % 0.58–28.5) was calculated by probit analysis. Caudal fin hypertrophy, head, yolk sac edema, caudal region, or somite malformations were observed. Secondary metabolites such as terpenes, polyphenols, and fatty acids were identified in the n-hexane extract. Also, pollutants such as diglycidyl resorcinol ether, diisopropyl adipate, and lauryl sulfate were found in the n-hexane extract. Our study revealed that chemical pollutants could be associated with the embryonic toxicity of the n-hexane extract of E. foetidum. |
| format | Article |
| id | doaj-art-72cd087b800e4c89854afa71f80ebe8c |
| institution | DOAJ |
| issn | 1846-9558 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-72cd087b800e4c89854afa71f80ebe8c2025-08-20T03:10:17ZengSciendoActa Pharmaceutica1846-95582025-03-0175113314610.2478/acph-2025-0008Untargeted metabolic analysis using LC-Q-TOF-MS and toxicity assessment of Eryngium foetidum in zebrafish embryosVázquez-Cancino Romario0Rodríguez-Morales Sergio1Jiménez-Pérez Nelly Del Carmen2Peña-Morán Omar Aristeo3Cerón-Romero Litzia4Sánchez-Lombardo Irma5Yair-Hidalgo Alam6Ceronio Nancy Romero7Alvarado-Sánchez Cuauhtémoc8Hernández-Abreu Oswaldo91Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco, Universidad Juárez Autónoma de Tabasco, 86690 Cunduacán, Tabasco, Mexico2Unidad de Química-Sisal, Facultad de Química, Universidad Nacional Autónoma de México, 97356 Sisal Yucatán, Mexico3Herbario UJAT, División Académica de Ciencias Biológicas, Universidad Juárez Autónoma de Tabasco, 86150, Villahermosa Tabasco, Mexico4División de Ciencias de la Salud, Universidad Autónoma del Estado de Quintana Roo, 77039 Chetumal, Quintana Roo, Mexico4División de Ciencias de la Salud, Universidad Autónoma del Estado de Quintana Roo, 77039 Chetumal, Quintana Roo, Mexico1Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco, Universidad Juárez Autónoma de Tabasco, 86690 Cunduacán, Tabasco, Mexico1Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco, Universidad Juárez Autónoma de Tabasco, 86690 Cunduacán, Tabasco, Mexico1Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco, Universidad Juárez Autónoma de Tabasco, 86690 Cunduacán, Tabasco, Mexico1Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco, Universidad Juárez Autónoma de Tabasco, 86690 Cunduacán, Tabasco, Mexico1Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco, Universidad Juárez Autónoma de Tabasco, 86690 Cunduacán, Tabasco, MexicoToxicological studies of edible plant species are important to determine the safety of their consumption. Eryngium foetidum is an edible plant used in some countries for seasoning food and as a natural remedy in folk medicine. Despite this species’ gastronomic and medicinal properties, the chemical composition and toxicity have been unclear. The objective of our investigation was to determine the toxic potential of E. foetidum in the zebrafish embryo model and identify the potential compounds involved in its toxicity by electrospray ionization liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry. Acute exposure of zebrafish embryos to n-hexane extract produced higher toxicity than the other extracts in a time- and concentration-dependent fashion (coagulated embryo). A 96-h median lethal concentration (LC50) of 2.63 µg mL–1 (CI 95 % 0.58–28.5) was calculated by probit analysis. Caudal fin hypertrophy, head, yolk sac edema, caudal region, or somite malformations were observed. Secondary metabolites such as terpenes, polyphenols, and fatty acids were identified in the n-hexane extract. Also, pollutants such as diglycidyl resorcinol ether, diisopropyl adipate, and lauryl sulfate were found in the n-hexane extract. Our study revealed that chemical pollutants could be associated with the embryonic toxicity of the n-hexane extract of E. foetidum.https://doi.org/10.2478/acph-2025-0008eryngium foetidummetabolic profiletoxicityzebrafishlc-q-tof-ms |
| spellingShingle | Vázquez-Cancino Romario Rodríguez-Morales Sergio Jiménez-Pérez Nelly Del Carmen Peña-Morán Omar Aristeo Cerón-Romero Litzia Sánchez-Lombardo Irma Yair-Hidalgo Alam Ceronio Nancy Romero Alvarado-Sánchez Cuauhtémoc Hernández-Abreu Oswaldo Untargeted metabolic analysis using LC-Q-TOF-MS and toxicity assessment of Eryngium foetidum in zebrafish embryos Acta Pharmaceutica eryngium foetidum metabolic profile toxicity zebrafish lc-q-tof-ms |
| title | Untargeted metabolic analysis using LC-Q-TOF-MS and toxicity assessment of Eryngium foetidum in zebrafish embryos |
| title_full | Untargeted metabolic analysis using LC-Q-TOF-MS and toxicity assessment of Eryngium foetidum in zebrafish embryos |
| title_fullStr | Untargeted metabolic analysis using LC-Q-TOF-MS and toxicity assessment of Eryngium foetidum in zebrafish embryos |
| title_full_unstemmed | Untargeted metabolic analysis using LC-Q-TOF-MS and toxicity assessment of Eryngium foetidum in zebrafish embryos |
| title_short | Untargeted metabolic analysis using LC-Q-TOF-MS and toxicity assessment of Eryngium foetidum in zebrafish embryos |
| title_sort | untargeted metabolic analysis using lc q tof ms and toxicity assessment of eryngium foetidum in zebrafish embryos |
| topic | eryngium foetidum metabolic profile toxicity zebrafish lc-q-tof-ms |
| url | https://doi.org/10.2478/acph-2025-0008 |
| work_keys_str_mv | AT vazquezcancinoromario untargetedmetabolicanalysisusinglcqtofmsandtoxicityassessmentoferyngiumfoetiduminzebrafishembryos AT rodriguezmoralessergio untargetedmetabolicanalysisusinglcqtofmsandtoxicityassessmentoferyngiumfoetiduminzebrafishembryos AT jimenezpereznellydelcarmen untargetedmetabolicanalysisusinglcqtofmsandtoxicityassessmentoferyngiumfoetiduminzebrafishembryos AT penamoranomararisteo untargetedmetabolicanalysisusinglcqtofmsandtoxicityassessmentoferyngiumfoetiduminzebrafishembryos AT ceronromerolitzia untargetedmetabolicanalysisusinglcqtofmsandtoxicityassessmentoferyngiumfoetiduminzebrafishembryos AT sanchezlombardoirma untargetedmetabolicanalysisusinglcqtofmsandtoxicityassessmentoferyngiumfoetiduminzebrafishembryos AT yairhidalgoalam untargetedmetabolicanalysisusinglcqtofmsandtoxicityassessmentoferyngiumfoetiduminzebrafishembryos AT ceronionancyromero untargetedmetabolicanalysisusinglcqtofmsandtoxicityassessmentoferyngiumfoetiduminzebrafishembryos AT alvaradosanchezcuauhtemoc untargetedmetabolicanalysisusinglcqtofmsandtoxicityassessmentoferyngiumfoetiduminzebrafishembryos AT hernandezabreuoswaldo untargetedmetabolicanalysisusinglcqtofmsandtoxicityassessmentoferyngiumfoetiduminzebrafishembryos |