Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy
ABSTRACT Background Diabetes represents a significant global health concern, with diabetic cardiomyopathy (DCM) emerging as a primary cause of mortality among individuals with diabetes. Despite the prevalence of DCM, advancements in therapeutic and preventative strategies remain constrained. Methods...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
|
| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.70116 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849433505634713600 |
|---|---|
| author | Qian Lei Burton B. Yang Juanjuan Lyu |
| author_facet | Qian Lei Burton B. Yang Juanjuan Lyu |
| author_sort | Qian Lei |
| collection | DOAJ |
| description | ABSTRACT Background Diabetes represents a significant global health concern, with diabetic cardiomyopathy (DCM) emerging as a primary cause of mortality among individuals with diabetes. Despite the prevalence of DCM, advancements in therapeutic and preventative strategies remain constrained. Methods Recent studies were reviewed to provide a comprehensive summary of pathogenesis and clinical treatment of DCM, effect of ferroptosis, and potential value of ferroptosis inhibitors in DCM intervention. Results A growing body of research indicates that oxidative stress, inflammatory reactions, and other factors play a role in the onset and progression of DCM. Oxidative stress within cardiomyocytes is a primary mechanism implicated in the development of DCM, whereby heightened intracellular reactive oxygen species (ROS) facilitate cell death via ferroptosis. Ferroptosis inhibitors hold great promise as therapeutic agents. Conclusions This review provides an overview of the involvement of iron homeostasis regulation, oxidative stress, and ferroptosis in DCM, and the significance of ferroptosis in the prevention and treatment of DCM. |
| format | Article |
| id | doaj-art-72cbccc426ff46c9b5ffe01397fcfe28 |
| institution | Kabale University |
| issn | 1753-0393 1753-0407 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj-art-72cbccc426ff46c9b5ffe01397fcfe282025-08-20T03:27:01ZengWileyJournal of Diabetes1753-03931753-04072025-06-01176n/an/a10.1111/1753-0407.70116Potential Significance of Targeting Ferroptosis for Intervention of Diabetic CardiomyopathyQian Lei0Burton B. Yang1Juanjuan Lyu2Anesthesia and Operation Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu ChinaSunnybrook Research Institute, and Department of Laboratory Medicine and Pathobiology University of Toronto Toronto CanadaDepartment of Pediatrics, West China Second University Hospital Sichuan University Chengdu ChinaABSTRACT Background Diabetes represents a significant global health concern, with diabetic cardiomyopathy (DCM) emerging as a primary cause of mortality among individuals with diabetes. Despite the prevalence of DCM, advancements in therapeutic and preventative strategies remain constrained. Methods Recent studies were reviewed to provide a comprehensive summary of pathogenesis and clinical treatment of DCM, effect of ferroptosis, and potential value of ferroptosis inhibitors in DCM intervention. Results A growing body of research indicates that oxidative stress, inflammatory reactions, and other factors play a role in the onset and progression of DCM. Oxidative stress within cardiomyocytes is a primary mechanism implicated in the development of DCM, whereby heightened intracellular reactive oxygen species (ROS) facilitate cell death via ferroptosis. Ferroptosis inhibitors hold great promise as therapeutic agents. Conclusions This review provides an overview of the involvement of iron homeostasis regulation, oxidative stress, and ferroptosis in DCM, and the significance of ferroptosis in the prevention and treatment of DCM.https://doi.org/10.1111/1753-0407.70116diabetesdiabetic cardiomyopathyferroptosislipid peroxidationreactive oxygen species |
| spellingShingle | Qian Lei Burton B. Yang Juanjuan Lyu Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy Journal of Diabetes diabetes diabetic cardiomyopathy ferroptosis lipid peroxidation reactive oxygen species |
| title | Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy |
| title_full | Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy |
| title_fullStr | Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy |
| title_full_unstemmed | Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy |
| title_short | Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy |
| title_sort | potential significance of targeting ferroptosis for intervention of diabetic cardiomyopathy |
| topic | diabetes diabetic cardiomyopathy ferroptosis lipid peroxidation reactive oxygen species |
| url | https://doi.org/10.1111/1753-0407.70116 |
| work_keys_str_mv | AT qianlei potentialsignificanceoftargetingferroptosisforinterventionofdiabeticcardiomyopathy AT burtonbyang potentialsignificanceoftargetingferroptosisforinterventionofdiabeticcardiomyopathy AT juanjuanlyu potentialsignificanceoftargetingferroptosisforinterventionofdiabeticcardiomyopathy |