Research progress of circular RNA FOXO3 in diseases (review)
Circular RNAs (circRNAs) are a newly discovered class of endogenous non-coding RNAs with a closed-loop structures, and they exert crucial regulatory functions in diverse biological processes and disease development through the modulation of linear RNA transcription, downstream gene expression, and p...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Global Medical Genetics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2699940424000031 |
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| author | Min Zhao Minting Lin Zhibo Zhang Linhu Ye |
| author_facet | Min Zhao Minting Lin Zhibo Zhang Linhu Ye |
| author_sort | Min Zhao |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) are a newly discovered class of endogenous non-coding RNAs with a closed-loop structures, and they exert crucial regulatory functions in diverse biological processes and disease development through the modulation of linear RNA transcription, downstream gene expression, and protein translation, among others. Circular RNA FOXO3(circFOXO3, Hsa_circ_0006404) originates from exon 2 of the FOXO3 gene and exhibits widespread cytoplasmic expression in eukaryotic cells. It shows specific expression in different tissues or cells. Recent research has associated circFOXO3 with various diseases such as cancer, cardiovascular diseases, neurological disorders, senescence, and inflammation. However, a comprehensive review of the research progress of circFOXO3 in human diseases has not been conducted. In this paper, we provide a systematic review of the latest advances in circFOXO3 research in diseases, elucidate its biological functions and potential molecular mechanisms, and discuss the future directions and challenges in circRNAs research to provide valuable references and inspiration for research in this field. |
| format | Article |
| id | doaj-art-72cb217411a9431eb7d27cffc20a245e |
| institution | OA Journals |
| issn | 2699-9404 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Global Medical Genetics |
| spelling | doaj-art-72cb217411a9431eb7d27cffc20a245e2025-08-20T02:03:46ZengKeAi Communications Co., Ltd.Global Medical Genetics2699-94042025-03-0112110000310.1016/j.gmg.2024.100003Research progress of circular RNA FOXO3 in diseases (review)Min Zhao0Minting Lin1Zhibo Zhang2Linhu Ye3Good Clinical Practice(GCP) Institutional Office of The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, China; The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, ChinaGood Clinical Practice(GCP) Institutional Office of The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, China; The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, ChinaGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), ChinaThe Sixth Affiliated Hospital, School of Medicine, South China University of Technology, China; Correspondence to: The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, No. 120, Guidan Road, Foshan, Guangdong Province 528200, China.Circular RNAs (circRNAs) are a newly discovered class of endogenous non-coding RNAs with a closed-loop structures, and they exert crucial regulatory functions in diverse biological processes and disease development through the modulation of linear RNA transcription, downstream gene expression, and protein translation, among others. Circular RNA FOXO3(circFOXO3, Hsa_circ_0006404) originates from exon 2 of the FOXO3 gene and exhibits widespread cytoplasmic expression in eukaryotic cells. It shows specific expression in different tissues or cells. Recent research has associated circFOXO3 with various diseases such as cancer, cardiovascular diseases, neurological disorders, senescence, and inflammation. However, a comprehensive review of the research progress of circFOXO3 in human diseases has not been conducted. In this paper, we provide a systematic review of the latest advances in circFOXO3 research in diseases, elucidate its biological functions and potential molecular mechanisms, and discuss the future directions and challenges in circRNAs research to provide valuable references and inspiration for research in this field.http://www.sciencedirect.com/science/article/pii/S2699940424000031CircFOXO3, circRNAsMiRNA spongeDisease pathogenesisBiomarkers |
| spellingShingle | Min Zhao Minting Lin Zhibo Zhang Linhu Ye Research progress of circular RNA FOXO3 in diseases (review) Global Medical Genetics CircFOXO3, circRNAs MiRNA sponge Disease pathogenesis Biomarkers |
| title | Research progress of circular RNA FOXO3 in diseases (review) |
| title_full | Research progress of circular RNA FOXO3 in diseases (review) |
| title_fullStr | Research progress of circular RNA FOXO3 in diseases (review) |
| title_full_unstemmed | Research progress of circular RNA FOXO3 in diseases (review) |
| title_short | Research progress of circular RNA FOXO3 in diseases (review) |
| title_sort | research progress of circular rna foxo3 in diseases review |
| topic | CircFOXO3, circRNAs MiRNA sponge Disease pathogenesis Biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S2699940424000031 |
| work_keys_str_mv | AT minzhao researchprogressofcircularrnafoxo3indiseasesreview AT mintinglin researchprogressofcircularrnafoxo3indiseasesreview AT zhibozhang researchprogressofcircularrnafoxo3indiseasesreview AT linhuye researchprogressofcircularrnafoxo3indiseasesreview |