Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing
This study introduces a cutting-edge, aptamer-based, planar electric, double-layer field-effect transistor (FET) system that offers both high sensitivity and specificity for the detection of troponin I (TnI). The proposed sensing platform leverages the signal amplification capabilities of FETs along...
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MDPI AG
2025-04-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/5/285 |
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| author | Sheng-Chun Hung Yi-Hua Lee |
| author_facet | Sheng-Chun Hung Yi-Hua Lee |
| author_sort | Sheng-Chun Hung |
| collection | DOAJ |
| description | This study introduces a cutting-edge, aptamer-based, planar electric, double-layer field-effect transistor (FET) system that offers both high sensitivity and specificity for the detection of troponin I (TnI). The proposed sensing platform leverages the signal amplification capabilities of FETs alongside the unique attributes of a planar electric double-layer design to address the limitations inherent in traditional ion-sensitive detectors, which are impacted by Debye length effects. By integrating TnI-specific aptamers, the system markedly enhances molecular recognition and transduction efficiency, achieving an impressive detection limit of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>0.0001467</mn><mo> </mo><mi mathvariant="normal">d</mi><mi mathvariant="normal">e</mi><mi mathvariant="normal">c</mi><mi mathvariant="normal">a</mi><mi mathvariant="normal">d</mi><mi mathvariant="normal">e</mi></mrow></semantics></math></inline-formula>. Furthermore, the sensor demonstrates a strong exponential linear response across a clinically relevant concentration range of 1 ng/mL to 100 ng/mL. This innovative approach underscores the potential of electric double-layer FET systems to advance biomarker detection technologies for medical diagnostics and point-of-care applications. |
| format | Article |
| id | doaj-art-72c93ea3596a48339d2a4694e27b9978 |
| institution | OA Journals |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-72c93ea3596a48339d2a4694e27b99782025-08-20T01:56:20ZengMDPI AGBiosensors2079-63742025-04-0115528510.3390/bios15050285Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I SensingSheng-Chun Hung0Yi-Hua Lee1Department of Electrical Engineering, Feng Chia University, Taichung City 407102, TaiwanDepartment of Electrical Engineering, Feng Chia University, Taichung City 407102, TaiwanThis study introduces a cutting-edge, aptamer-based, planar electric, double-layer field-effect transistor (FET) system that offers both high sensitivity and specificity for the detection of troponin I (TnI). The proposed sensing platform leverages the signal amplification capabilities of FETs alongside the unique attributes of a planar electric double-layer design to address the limitations inherent in traditional ion-sensitive detectors, which are impacted by Debye length effects. By integrating TnI-specific aptamers, the system markedly enhances molecular recognition and transduction efficiency, achieving an impressive detection limit of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>0.0001467</mn><mo> </mo><mi mathvariant="normal">d</mi><mi mathvariant="normal">e</mi><mi mathvariant="normal">c</mi><mi mathvariant="normal">a</mi><mi mathvariant="normal">d</mi><mi mathvariant="normal">e</mi></mrow></semantics></math></inline-formula>. Furthermore, the sensor demonstrates a strong exponential linear response across a clinically relevant concentration range of 1 ng/mL to 100 ng/mL. This innovative approach underscores the potential of electric double-layer FET systems to advance biomarker detection technologies for medical diagnostics and point-of-care applications.https://www.mdpi.com/2079-6374/15/5/285aptamer-based sensingplanar electric double-layerfield-effect transistortroponin I detectiondebye length effectspoint-of-care diagnostics |
| spellingShingle | Sheng-Chun Hung Yi-Hua Lee Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing Biosensors aptamer-based sensing planar electric double-layer field-effect transistor troponin I detection debye length effects point-of-care diagnostics |
| title | Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing |
| title_full | Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing |
| title_fullStr | Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing |
| title_full_unstemmed | Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing |
| title_short | Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing |
| title_sort | aptamer based planar electric double layer field effect transistor a novel approach for sensitive troponin i sensing |
| topic | aptamer-based sensing planar electric double-layer field-effect transistor troponin I detection debye length effects point-of-care diagnostics |
| url | https://www.mdpi.com/2079-6374/15/5/285 |
| work_keys_str_mv | AT shengchunhung aptamerbasedplanarelectricdoublelayerfieldeffecttransistoranovelapproachforsensitivetroponinisensing AT yihualee aptamerbasedplanarelectricdoublelayerfieldeffecttransistoranovelapproachforsensitivetroponinisensing |