Auger electron-emitting EGFR-targeted and non-targeted [197Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM)

Auger electron-emitting EGFR-targeted and non-targeted [197Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM)

Abstract Background We describe here radiation nanomedicines for glioblastoma multiforme (GBM) composed of gold nanoparticles (AuNPs) that integrate the Auger electron-emitter, 197Hg. [197Hg]Hg-AuNPs were conjugated to anti-epidermal growth factor receptor (EGFR) panitumumab or were non-targeted. Ou...

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Bibliographic Details
Main Authors: Madeline K. Brown, Zhongli Cai, Constantine J. Georgiou, Shaohuang Chen, Yumeela Ganga-Sah, Valery Radchenko, James T. Rutka, Raymond M. Reilly
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Glioblastoma multiforme (GBM)
Gold nanoparticles
197Hg
Auger electrons
Panitumumab
Epidermal growth factor receptors (EGFR)
Online Access:https://doi.org/10.1186/s41181-025-00367-2
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