Biomonitoring with Micronuclei Test in Buccal Cells of Female Farmers and Children Exposed to Pesticides of Maneadero Agricultural Valley, Baja California, Mexico
Feminization of the agricultural labor is common in Mexico; these women and their families are vulnerable to several health risks including genotoxicity. Previous papers have presented contradictory information with respect to indirect exposure to pesticides and DNA damage. We aimed to evaluate the...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2016/7934257 |
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| author | Idalia Jazmin Castañeda-Yslas María Evarista Arellano-García Marco Antonio García-Zarate Balam Ruíz-Ruíz María Guadalupe Zavala-Cerna Olivia Torres-Bugarín |
| author_facet | Idalia Jazmin Castañeda-Yslas María Evarista Arellano-García Marco Antonio García-Zarate Balam Ruíz-Ruíz María Guadalupe Zavala-Cerna Olivia Torres-Bugarín |
| author_sort | Idalia Jazmin Castañeda-Yslas |
| collection | DOAJ |
| description | Feminization of the agricultural labor is common in Mexico; these women and their families are vulnerable to several health risks including genotoxicity. Previous papers have presented contradictory information with respect to indirect exposure to pesticides and DNA damage. We aimed to evaluate the genotoxic effect in buccal mucosa from female farmers and children, working in the agricultural valley of Maneadero, Baja California. Frequencies of micronucleated cells (MNc) and nuclear abnormalities (NA) in 2000 cells were obtained from the buccal mucosa of the study population (n=144), divided in four groups: (1) farmers (n=37), (2) unexposed (n=35), (3) farmers’ children (n=34), and (4) unexposed children (n=38). We compared frequencies of MNc and NA and fitted generalized linear models to investigate the interaction between these variables and exposition to pesticides. Differences were found between farmers and unexposed women in MNc (p<0.0001), CC (p=0.3376), and PN (p<0.0001). With respect to exposed children, we found higher significant frequencies in MNc (p<0.0001), LN (p<0.0001), CC (p<0.0001), and PN (p<0.004) when compared to unexposed children. Therefore working as a farmer is a risk for genotoxic damage; more importantly indirectly exposed children were found to have genotoxic damage, which is of concern, since it could aid in future disturbances of their health. |
| format | Article |
| id | doaj-art-72c006c5ba8348fea03f6956336997ef |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-72c006c5ba8348fea03f6956336997ef2025-02-03T06:13:26ZengWileyJournal of Toxicology1687-81911687-82052016-01-01201610.1155/2016/79342577934257Biomonitoring with Micronuclei Test in Buccal Cells of Female Farmers and Children Exposed to Pesticides of Maneadero Agricultural Valley, Baja California, MexicoIdalia Jazmin Castañeda-Yslas0María Evarista Arellano-García1Marco Antonio García-Zarate2Balam Ruíz-Ruíz3María Guadalupe Zavala-Cerna4Olivia Torres-Bugarín5Facultad de Ciencias, Universidad Autónoma de Baja California, 22800 Ensenada, BC, MexicoFacultad de Ciencias, Universidad Autónoma de Baja California, 22800 Ensenada, BC, MexicoCentro de Investigación Científica y de Educación Superior de Ensenada, 22800 Ensenada, BC, MexicoEscuela de Ciencias de la Salud, Universidad Autónoma de Baja California, 22800 Ensenada, BC, MexicoSchool of Medicine, Universidad Autónoma de Guadalajara, 44100 Guadalajara, JAL, MexicoSchool of Medicine, Universidad Autónoma de Guadalajara, 44100 Guadalajara, JAL, MexicoFeminization of the agricultural labor is common in Mexico; these women and their families are vulnerable to several health risks including genotoxicity. Previous papers have presented contradictory information with respect to indirect exposure to pesticides and DNA damage. We aimed to evaluate the genotoxic effect in buccal mucosa from female farmers and children, working in the agricultural valley of Maneadero, Baja California. Frequencies of micronucleated cells (MNc) and nuclear abnormalities (NA) in 2000 cells were obtained from the buccal mucosa of the study population (n=144), divided in four groups: (1) farmers (n=37), (2) unexposed (n=35), (3) farmers’ children (n=34), and (4) unexposed children (n=38). We compared frequencies of MNc and NA and fitted generalized linear models to investigate the interaction between these variables and exposition to pesticides. Differences were found between farmers and unexposed women in MNc (p<0.0001), CC (p=0.3376), and PN (p<0.0001). With respect to exposed children, we found higher significant frequencies in MNc (p<0.0001), LN (p<0.0001), CC (p<0.0001), and PN (p<0.004) when compared to unexposed children. Therefore working as a farmer is a risk for genotoxic damage; more importantly indirectly exposed children were found to have genotoxic damage, which is of concern, since it could aid in future disturbances of their health.http://dx.doi.org/10.1155/2016/7934257 |
| spellingShingle | Idalia Jazmin Castañeda-Yslas María Evarista Arellano-García Marco Antonio García-Zarate Balam Ruíz-Ruíz María Guadalupe Zavala-Cerna Olivia Torres-Bugarín Biomonitoring with Micronuclei Test in Buccal Cells of Female Farmers and Children Exposed to Pesticides of Maneadero Agricultural Valley, Baja California, Mexico Journal of Toxicology |
| title | Biomonitoring with Micronuclei Test in Buccal Cells of Female Farmers and Children Exposed to Pesticides of Maneadero Agricultural Valley, Baja California, Mexico |
| title_full | Biomonitoring with Micronuclei Test in Buccal Cells of Female Farmers and Children Exposed to Pesticides of Maneadero Agricultural Valley, Baja California, Mexico |
| title_fullStr | Biomonitoring with Micronuclei Test in Buccal Cells of Female Farmers and Children Exposed to Pesticides of Maneadero Agricultural Valley, Baja California, Mexico |
| title_full_unstemmed | Biomonitoring with Micronuclei Test in Buccal Cells of Female Farmers and Children Exposed to Pesticides of Maneadero Agricultural Valley, Baja California, Mexico |
| title_short | Biomonitoring with Micronuclei Test in Buccal Cells of Female Farmers and Children Exposed to Pesticides of Maneadero Agricultural Valley, Baja California, Mexico |
| title_sort | biomonitoring with micronuclei test in buccal cells of female farmers and children exposed to pesticides of maneadero agricultural valley baja california mexico |
| url | http://dx.doi.org/10.1155/2016/7934257 |
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