Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus
IntroductionType 2 diabetes mellitus (T2DM) often leads to elevated blood glucose levels and lipid metabolism disorder, which is generally accompanied by dysbiosis of gut microbiota and metabolic dysfunction.MethodsIn this study, a mouse model of T2DM was established by feeding a high-fat/sucrose di...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1499196/full |
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| author | Xuemei Yin Yinzi Sui Zhengyan Chu Suqing Han Xiaodong Ge Tingting Liu Feng Zeng Ligen Chen Rong Shao Wei Xu |
| author_facet | Xuemei Yin Yinzi Sui Zhengyan Chu Suqing Han Xiaodong Ge Tingting Liu Feng Zeng Ligen Chen Rong Shao Wei Xu |
| author_sort | Xuemei Yin |
| collection | DOAJ |
| description | IntroductionType 2 diabetes mellitus (T2DM) often leads to elevated blood glucose levels and lipid metabolism disorder, which is generally accompanied by dysbiosis of gut microbiota and metabolic dysfunction.MethodsIn this study, a mouse model of T2DM was established by feeding a high-fat/sucrose diet combined with injecting a low dose of streptozotocin. The aim of this study was to analyze the regulatory effect of Suaeda salsa extract (SSE) on T2DM and its effect on the intestinal flora of mice.ResultsThe results showed that SSE could significantly improve the body weight, fasting blood glucose (FBG), area under the curve (AUC) of the oral glucose tolerance test (OGTT), glycosylated serum protein (GSP) and islet function index. Moreover, 4-week body weight, FBG, AUC of OGTT, GSP, as well as intestinal acetic and butyric acid were significantly better in the SSE-L than in the MET group (p < 0.05). In addition, it was also found that the potential hypoglycemic mechanism of SSE was related to the expression of Akt serine/threonine kinase (AKT-1) and glucose transporter-2 (GLUT-2) genes. Compared with the model group, SSE intervention significantly increased the abundance of probiotics, such as Soleaferrea, Alloprevotella, Lactobacillus and Faecalibaculum, while decreasing the relative abundance of harmful bacteria, such as Phocaeicola and Bilophila. Analysis of the correlation among intestinal microbiota, short chain fatty acids (SCFAs) and the hypoglycemic index showed that Dwaynesavagella was significantly correlated with acetic, propionic and butyric acid, as well as all the diabetes-related indexes analyzed in this study.DiscussionThus, this taxon can potentially be used as a microbiological marker of type 2 diabetes. Taken together, these findings demonstrate that SSE can alleviate T2DM and its complications by improving glycemia-related indicators and modulating the structure of intestinal flora. |
| format | Article |
| id | doaj-art-72be4e8d31524facacd8b9be86177a01 |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-72be4e8d31524facacd8b9be86177a012025-08-20T02:35:46ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-12-011110.3389/fnut.2024.14991961499196Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitusXuemei Yin0Yinzi Sui1Zhengyan Chu2Suqing Han3Xiaodong Ge4Tingting Liu5Feng Zeng6Ligen Chen7Rong Shao8Wei Xu9College of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, ChinaCollege of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, ChinaCollege of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, ChinaCollege of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, ChinaCollege of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, ChinaClinical Pharmacy Department, Yancheng Second People’s Hospital, Yancheng, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, ChinaCollege of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, ChinaCollege of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, ChinaCollege of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, ChinaIntroductionType 2 diabetes mellitus (T2DM) often leads to elevated blood glucose levels and lipid metabolism disorder, which is generally accompanied by dysbiosis of gut microbiota and metabolic dysfunction.MethodsIn this study, a mouse model of T2DM was established by feeding a high-fat/sucrose diet combined with injecting a low dose of streptozotocin. The aim of this study was to analyze the regulatory effect of Suaeda salsa extract (SSE) on T2DM and its effect on the intestinal flora of mice.ResultsThe results showed that SSE could significantly improve the body weight, fasting blood glucose (FBG), area under the curve (AUC) of the oral glucose tolerance test (OGTT), glycosylated serum protein (GSP) and islet function index. Moreover, 4-week body weight, FBG, AUC of OGTT, GSP, as well as intestinal acetic and butyric acid were significantly better in the SSE-L than in the MET group (p < 0.05). In addition, it was also found that the potential hypoglycemic mechanism of SSE was related to the expression of Akt serine/threonine kinase (AKT-1) and glucose transporter-2 (GLUT-2) genes. Compared with the model group, SSE intervention significantly increased the abundance of probiotics, such as Soleaferrea, Alloprevotella, Lactobacillus and Faecalibaculum, while decreasing the relative abundance of harmful bacteria, such as Phocaeicola and Bilophila. Analysis of the correlation among intestinal microbiota, short chain fatty acids (SCFAs) and the hypoglycemic index showed that Dwaynesavagella was significantly correlated with acetic, propionic and butyric acid, as well as all the diabetes-related indexes analyzed in this study.DiscussionThus, this taxon can potentially be used as a microbiological marker of type 2 diabetes. Taken together, these findings demonstrate that SSE can alleviate T2DM and its complications by improving glycemia-related indicators and modulating the structure of intestinal flora.https://www.frontiersin.org/articles/10.3389/fnut.2024.1499196/fullSuaeda salsa extractT2DMhyperglycemiametabolic dysfunctionintestinal flora |
| spellingShingle | Xuemei Yin Yinzi Sui Zhengyan Chu Suqing Han Xiaodong Ge Tingting Liu Feng Zeng Ligen Chen Rong Shao Wei Xu Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus Frontiers in Nutrition Suaeda salsa extract T2DM hyperglycemia metabolic dysfunction intestinal flora |
| title | Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus |
| title_full | Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus |
| title_fullStr | Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus |
| title_full_unstemmed | Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus |
| title_short | Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus |
| title_sort | regulation of intestinal flora by suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus |
| topic | Suaeda salsa extract T2DM hyperglycemia metabolic dysfunction intestinal flora |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1499196/full |
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