Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study
Abstract Background Improving maternal and child health has been a global priority since the early 2000s, with a focus on reducing perinatal complications and improving overall maternal well-being. Sleep characteristics influence various health outcomes, yet their role in perinatal complications and...
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BMC
2025-05-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-025-07754-2 |
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| author | Ning Wang Ting Wang Meiling Tang Biqi Zu Jiamiao Chen |
| author_facet | Ning Wang Ting Wang Meiling Tang Biqi Zu Jiamiao Chen |
| author_sort | Ning Wang |
| collection | DOAJ |
| description | Abstract Background Improving maternal and child health has been a global priority since the early 2000s, with a focus on reducing perinatal complications and improving overall maternal well-being. Sleep characteristics influence various health outcomes, yet their role in perinatal complications and adverse outcomes remains poorly understood. Methods A Mendelian randomization analysis was conducted, using seven common sleep characteristics (sleeplessness, sleep duration, getting up in the morning, daytime napping, morning/evening person, narcolepsy, snoring) as exposure factors and twelve common perinatal complications and adverse outcomes (preterm birth, polyhydramnios, slow fetal growth and fetal malnutrition, dystocia, umbilical cord-related complications, postpartum hemorrhage, fetal distress, gestational diabetes, pregnancy hypertension, eclampsia, abruptio placentae, placenta previa) as outcomes. A two-sample Mendelian randomization analysis was performed to infer causal effects. Results The inverse variance weighted (IVW) analysis showed that sleeplessness was associated with preterm birth, sleep duration with gestational diabetes, and narcolepsy with pregnancy hypertension and eclampsia. These results were consistently supported by other methods, suggesting that sleep characteristics are causal risk factors for perinatal complications and adverse outcomes. Conclusion This study found that sleeplessness is associated with preterm birth, sleep duration with gestational diabetes, and narcolepsy with pregnancy hypertension and eclampsia. These findings contribute to a better understanding of the impact of sleep characteristics on common perinatal complications and adverse outcomes. Targeting sleep interventions, such as improving sleep duration and addressing sleep disorders like sleeplessness and narcolepsy, may reduce the incidence of preterm birth, gestational diabetes, and pregnancy hypertension, offering effective strategies to improve maternal and infant health outcomes. |
| format | Article |
| id | doaj-art-72bd65e074dd4f4aa6715a2f0f97dfce |
| institution | DOAJ |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-72bd65e074dd4f4aa6715a2f0f97dfce2025-08-20T03:16:31ZengBMCBMC Pregnancy and Childbirth1471-23932025-05-0125111110.1186/s12884-025-07754-2Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization studyNing Wang0Ting Wang1Meiling Tang2Biqi Zu3Jiamiao Chen4Obstetrics Department, Dalian Women and Children’s Medical GroupSchool of Nursing, Dalian UniversitySchool of Nursing, Qiqihar Medical CollegePsychiatry Department, Dalian Seventh People’s HospitalObstetrics Department, Dalian Women and Children’s Medical GroupAbstract Background Improving maternal and child health has been a global priority since the early 2000s, with a focus on reducing perinatal complications and improving overall maternal well-being. Sleep characteristics influence various health outcomes, yet their role in perinatal complications and adverse outcomes remains poorly understood. Methods A Mendelian randomization analysis was conducted, using seven common sleep characteristics (sleeplessness, sleep duration, getting up in the morning, daytime napping, morning/evening person, narcolepsy, snoring) as exposure factors and twelve common perinatal complications and adverse outcomes (preterm birth, polyhydramnios, slow fetal growth and fetal malnutrition, dystocia, umbilical cord-related complications, postpartum hemorrhage, fetal distress, gestational diabetes, pregnancy hypertension, eclampsia, abruptio placentae, placenta previa) as outcomes. A two-sample Mendelian randomization analysis was performed to infer causal effects. Results The inverse variance weighted (IVW) analysis showed that sleeplessness was associated with preterm birth, sleep duration with gestational diabetes, and narcolepsy with pregnancy hypertension and eclampsia. These results were consistently supported by other methods, suggesting that sleep characteristics are causal risk factors for perinatal complications and adverse outcomes. Conclusion This study found that sleeplessness is associated with preterm birth, sleep duration with gestational diabetes, and narcolepsy with pregnancy hypertension and eclampsia. These findings contribute to a better understanding of the impact of sleep characteristics on common perinatal complications and adverse outcomes. Targeting sleep interventions, such as improving sleep duration and addressing sleep disorders like sleeplessness and narcolepsy, may reduce the incidence of preterm birth, gestational diabetes, and pregnancy hypertension, offering effective strategies to improve maternal and infant health outcomes.https://doi.org/10.1186/s12884-025-07754-2Mendelian randomizationPerinatal complicationsSleep characteristicsGestational diabetesPreterm birth |
| spellingShingle | Ning Wang Ting Wang Meiling Tang Biqi Zu Jiamiao Chen Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study BMC Pregnancy and Childbirth Mendelian randomization Perinatal complications Sleep characteristics Gestational diabetes Preterm birth |
| title | Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study |
| title_full | Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study |
| title_fullStr | Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study |
| title_full_unstemmed | Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study |
| title_short | Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study |
| title_sort | common sleep characteristics and the risk of common perinatal complications and adverse outcomes a multi sample bidirectional mendelian randomization study |
| topic | Mendelian randomization Perinatal complications Sleep characteristics Gestational diabetes Preterm birth |
| url | https://doi.org/10.1186/s12884-025-07754-2 |
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