The effectiveness of liver transplantation in reducing lipid levels in Saudi children with homozygous familial hypercholesterolemia
IntroductionThe lipid profiles of patients aged <15 years who have been diagnosed with homozygous familial hypercholesterolemia (HoFH) at King Faisal Specialist Hospital & Research Center (Riyadh) were examined.MethodsThe total cholesterol and low-density lipoprotein cholesterol (LDL-...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1454638/full |
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| author | Abdullah Al-Ashwal Salman Al-Mansour Mohammed Al-Shagrani Talal Al-Gofi Dieter Broering Raghad Alhuthil |
| author_facet | Abdullah Al-Ashwal Salman Al-Mansour Mohammed Al-Shagrani Talal Al-Gofi Dieter Broering Raghad Alhuthil |
| author_sort | Abdullah Al-Ashwal |
| collection | DOAJ |
| description | IntroductionThe lipid profiles of patients aged <15 years who have been diagnosed with homozygous familial hypercholesterolemia (HoFH) at King Faisal Specialist Hospital & Research Center (Riyadh) were examined.MethodsThe total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels of 17 patients were measured on initial presentation and compared with the levels measured after pharmacological treatment and then again after liver transplantation.ResultsAt the end of the pharmacological treatment, the total cholesterol levels decreased by an average of 3.79 mmol/L (reduced by 15.40%) (P < 0.001), and LDL-C levels decreased on average by 2.73 mmol/L (reduced by 13.46%) (P = 0.014). However, in two patients, LDL-C levels increased by 5.42% and 9.03% after pharmacological treatment. Conversely, the lipid values measured after liver transplantation decreased significantly nearly to within normal and borderline limits. The post-transplant total cholesterol and LDL-C levels declined by a mean of 19.96 mmol/L (reduced by 81.04%) and 17.47 mmol/L (reduced by 84.27%), respectively (P < 0.001 for both).DiscussionThese findings suggest that liver transplantation provides a more effective means to reduce elevated total cholesterol and LDL-C levels in patients with HoFH. Although liver transplantation is considered a better treatment for FHoH, risks, complications, and donor organ shortage may present problems. |
| format | Article |
| id | doaj-art-72bc5b6b89db4ef48521f73eccd731d4 |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-72bc5b6b89db4ef48521f73eccd731d42025-08-20T01:53:19ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-11-011110.3389/fcvm.2024.14546381454638The effectiveness of liver transplantation in reducing lipid levels in Saudi children with homozygous familial hypercholesterolemiaAbdullah Al-Ashwal0Salman Al-Mansour1Mohammed Al-Shagrani2Talal Al-Gofi3Dieter Broering4Raghad Alhuthil5Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi ArabiaDepartment of Pediatrics, College of Medicine, Qassim University, Buraydah, Saudi ArabiaDepartment of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi ArabiaDepartment of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi ArabiaDepartment of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi ArabiaDepartment of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi ArabiaIntroductionThe lipid profiles of patients aged <15 years who have been diagnosed with homozygous familial hypercholesterolemia (HoFH) at King Faisal Specialist Hospital & Research Center (Riyadh) were examined.MethodsThe total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels of 17 patients were measured on initial presentation and compared with the levels measured after pharmacological treatment and then again after liver transplantation.ResultsAt the end of the pharmacological treatment, the total cholesterol levels decreased by an average of 3.79 mmol/L (reduced by 15.40%) (P < 0.001), and LDL-C levels decreased on average by 2.73 mmol/L (reduced by 13.46%) (P = 0.014). However, in two patients, LDL-C levels increased by 5.42% and 9.03% after pharmacological treatment. Conversely, the lipid values measured after liver transplantation decreased significantly nearly to within normal and borderline limits. The post-transplant total cholesterol and LDL-C levels declined by a mean of 19.96 mmol/L (reduced by 81.04%) and 17.47 mmol/L (reduced by 84.27%), respectively (P < 0.001 for both).DiscussionThese findings suggest that liver transplantation provides a more effective means to reduce elevated total cholesterol and LDL-C levels in patients with HoFH. Although liver transplantation is considered a better treatment for FHoH, risks, complications, and donor organ shortage may present problems.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1454638/fullhomozygousfamilial hypercholesterolemiacholesterolLDL-Cliver transplant |
| spellingShingle | Abdullah Al-Ashwal Salman Al-Mansour Mohammed Al-Shagrani Talal Al-Gofi Dieter Broering Raghad Alhuthil The effectiveness of liver transplantation in reducing lipid levels in Saudi children with homozygous familial hypercholesterolemia Frontiers in Cardiovascular Medicine homozygous familial hypercholesterolemia cholesterol LDL-C liver transplant |
| title | The effectiveness of liver transplantation in reducing lipid levels in Saudi children with homozygous familial hypercholesterolemia |
| title_full | The effectiveness of liver transplantation in reducing lipid levels in Saudi children with homozygous familial hypercholesterolemia |
| title_fullStr | The effectiveness of liver transplantation in reducing lipid levels in Saudi children with homozygous familial hypercholesterolemia |
| title_full_unstemmed | The effectiveness of liver transplantation in reducing lipid levels in Saudi children with homozygous familial hypercholesterolemia |
| title_short | The effectiveness of liver transplantation in reducing lipid levels in Saudi children with homozygous familial hypercholesterolemia |
| title_sort | effectiveness of liver transplantation in reducing lipid levels in saudi children with homozygous familial hypercholesterolemia |
| topic | homozygous familial hypercholesterolemia cholesterol LDL-C liver transplant |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1454638/full |
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