Intraepithelial corneal deposits associated with Mirvetuximab soravtansine use for platinum-resistant ovarian cancer
Purpose: Present a case of Mirvetuximab soravtansine (MIRV)-induced intraepithelial corneal deposits, review a proposed mechanism to explain the blurred vision our patient experienced, and explain clinical exams that may be used to support the diagnosis. Observations: A 63-year-old female with metas...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | American Journal of Ophthalmology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993625000246 |
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| author | Charlotte McRae Rachael Cowan Macy Green Jack S. Parker |
| author_facet | Charlotte McRae Rachael Cowan Macy Green Jack S. Parker |
| author_sort | Charlotte McRae |
| collection | DOAJ |
| description | Purpose: Present a case of Mirvetuximab soravtansine (MIRV)-induced intraepithelial corneal deposits, review a proposed mechanism to explain the blurred vision our patient experienced, and explain clinical exams that may be used to support the diagnosis. Observations: A 63-year-old female with metastatic ovarian cancer diagnosed with intraepithelial corneal deposits two weeks after her first MIRV infusion. Treatment with topical prednisolone acetate 1 % ophthalmic suspension and lubricating eye drops without interruption of her MIRV infusions resulted in complete resolution of blurry vision and corneal deposits. Conclusions and importance: The natural reversibility of MIRV-induced keratopathies underscores the need for prompt and regular ophthalmic assessments throughout drug administration. Understanding the mechanism behind these corneal changes, how to recognize them in a clinical setting, and expedite their reversal are essential to improve quality-of-life metrics in patients receiving MIRV transfusions. |
| format | Article |
| id | doaj-art-72ba56b156b94e1eaf1fcbef9c276b69 |
| institution | Kabale University |
| issn | 2451-9936 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj-art-72ba56b156b94e1eaf1fcbef9c276b692025-02-12T05:31:29ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362025-06-0138102271Intraepithelial corneal deposits associated with Mirvetuximab soravtansine use for platinum-resistant ovarian cancerCharlotte McRae0Rachael Cowan1Macy Green2Jack S. Parker3University of Alabama at Birmingham School of Medicine, 1670 University Blvd, Birmingham, AL, 35233, USAUniversity of Alabama at Birmingham School of Medicine, 1670 University Blvd, Birmingham, AL, 35233, USAParker Cornea, 745 Corporate Woods Dr, Vestavia Hills, AL, 35242, USAParker Cornea, 745 Corporate Woods Dr, Vestavia Hills, AL, 35242, USA; Corresponding author. Parker Cornea, 3745 Corporate Woods Dr, Vestavia Hills, AL, 35242, USA.Purpose: Present a case of Mirvetuximab soravtansine (MIRV)-induced intraepithelial corneal deposits, review a proposed mechanism to explain the blurred vision our patient experienced, and explain clinical exams that may be used to support the diagnosis. Observations: A 63-year-old female with metastatic ovarian cancer diagnosed with intraepithelial corneal deposits two weeks after her first MIRV infusion. Treatment with topical prednisolone acetate 1 % ophthalmic suspension and lubricating eye drops without interruption of her MIRV infusions resulted in complete resolution of blurry vision and corneal deposits. Conclusions and importance: The natural reversibility of MIRV-induced keratopathies underscores the need for prompt and regular ophthalmic assessments throughout drug administration. Understanding the mechanism behind these corneal changes, how to recognize them in a clinical setting, and expedite their reversal are essential to improve quality-of-life metrics in patients receiving MIRV transfusions.http://www.sciencedirect.com/science/article/pii/S2451993625000246Ocular toxicityMirvetuximabCorneal depositCorneal curvatureMicrocyst-like epithelial changes (MECs) |
| spellingShingle | Charlotte McRae Rachael Cowan Macy Green Jack S. Parker Intraepithelial corneal deposits associated with Mirvetuximab soravtansine use for platinum-resistant ovarian cancer American Journal of Ophthalmology Case Reports Ocular toxicity Mirvetuximab Corneal deposit Corneal curvature Microcyst-like epithelial changes (MECs) |
| title | Intraepithelial corneal deposits associated with Mirvetuximab soravtansine use for platinum-resistant ovarian cancer |
| title_full | Intraepithelial corneal deposits associated with Mirvetuximab soravtansine use for platinum-resistant ovarian cancer |
| title_fullStr | Intraepithelial corneal deposits associated with Mirvetuximab soravtansine use for platinum-resistant ovarian cancer |
| title_full_unstemmed | Intraepithelial corneal deposits associated with Mirvetuximab soravtansine use for platinum-resistant ovarian cancer |
| title_short | Intraepithelial corneal deposits associated with Mirvetuximab soravtansine use for platinum-resistant ovarian cancer |
| title_sort | intraepithelial corneal deposits associated with mirvetuximab soravtansine use for platinum resistant ovarian cancer |
| topic | Ocular toxicity Mirvetuximab Corneal deposit Corneal curvature Microcyst-like epithelial changes (MECs) |
| url | http://www.sciencedirect.com/science/article/pii/S2451993625000246 |
| work_keys_str_mv | AT charlottemcrae intraepithelialcornealdepositsassociatedwithmirvetuximabsoravtansineuseforplatinumresistantovariancancer AT rachaelcowan intraepithelialcornealdepositsassociatedwithmirvetuximabsoravtansineuseforplatinumresistantovariancancer AT macygreen intraepithelialcornealdepositsassociatedwithmirvetuximabsoravtansineuseforplatinumresistantovariancancer AT jacksparker intraepithelialcornealdepositsassociatedwithmirvetuximabsoravtansineuseforplatinumresistantovariancancer |