Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in Glaucoma
Purpose. To investigate blood pressure and heart rate variability in patients with primary open-angle glaucoma (POAG) to detect disturbed blood pressure regulation. Methods. Thirty-one patients with POAG (mean age 68 ± 10 years) and 48 control subjects (mean age 66 ± 10 years) were included in a pro...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/798958 |
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| _version_ | 1832550702905294848 |
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| author | Eva Charlotte Koch Johanna Staab Matthias Fuest Katharina Witt Andreas Voss Niklas Plange |
| author_facet | Eva Charlotte Koch Johanna Staab Matthias Fuest Katharina Witt Andreas Voss Niklas Plange |
| author_sort | Eva Charlotte Koch |
| collection | DOAJ |
| description | Purpose. To investigate blood pressure and heart rate variability in patients with primary open-angle glaucoma (POAG) to detect disturbed blood pressure regulation. Methods. Thirty-one patients with POAG (mean age 68 ± 10 years) and 48 control subjects (mean age 66 ± 10 years) were included in a prospective study. Continuous blood pressure and heart rate were simultaneously and noninvasively recorded over 30 min (Glaucoscreen, aviant GmbH, Jena, Germany). Data were analyzed calculating univariate linear (time domain and frequency domain), nonlinear (Symbolic Dynamics, SD) and bivariate (Joint Symbolic Dynamics, JSD) indices. Results. Using nonlinear methods, glaucoma patients were separated with more parameters compared to linear methods. In POAG, nonlinear univariate indices (pW113 and pW120_Sys) were increased while the indices pTH10_Sys and pTH11_Sys reflect a reduction of dominant patterns. Bivariate indices (JSDdia29, JSDdia50, and JSDdia52; coupling between heart rate and diastolic blood pressure) were increased in POAG. The optimum set consisting of six parameters (JSDdia29, JSDdia58, pTH9_Sys, pW231, pW110_Sys and pW120_Sys) revealed a sensitivity of 83.3% and specificity of 80.6%. Conclusions. Nonlinear uni- and bivariate indices of continuous recordings of blood pressure and heart rate are altered in glaucoma. Abnormal blood pressure variability suggests disturbed autonomic regulation in patients with glaucoma. |
| format | Article |
| id | doaj-art-72b93eeb32ee4b9990a221962142bafc |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-72b93eeb32ee4b9990a221962142bafc2025-02-03T06:05:59ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/798958798958Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in GlaucomaEva Charlotte Koch0Johanna Staab1Matthias Fuest2Katharina Witt3Andreas Voss4Niklas Plange5Department of Ophthalmology, RWTH Aachen University, Pauwelsstraße 30, 52072 Aachen, GermanyDepartment of Ophthalmology, RWTH Aachen University, Pauwelsstraße 30, 52072 Aachen, GermanyDepartment of Ophthalmology, RWTH Aachen University, Pauwelsstraße 30, 52072 Aachen, GermanyDepartment of Medical Engineering and Biotechnology, Ernst-Abbe-Hochschule Jena, 07745 Jena, GermanyDepartment of Medical Engineering and Biotechnology, Ernst-Abbe-Hochschule Jena, 07745 Jena, GermanyDepartment of Ophthalmology, RWTH Aachen University, Pauwelsstraße 30, 52072 Aachen, GermanyPurpose. To investigate blood pressure and heart rate variability in patients with primary open-angle glaucoma (POAG) to detect disturbed blood pressure regulation. Methods. Thirty-one patients with POAG (mean age 68 ± 10 years) and 48 control subjects (mean age 66 ± 10 years) were included in a prospective study. Continuous blood pressure and heart rate were simultaneously and noninvasively recorded over 30 min (Glaucoscreen, aviant GmbH, Jena, Germany). Data were analyzed calculating univariate linear (time domain and frequency domain), nonlinear (Symbolic Dynamics, SD) and bivariate (Joint Symbolic Dynamics, JSD) indices. Results. Using nonlinear methods, glaucoma patients were separated with more parameters compared to linear methods. In POAG, nonlinear univariate indices (pW113 and pW120_Sys) were increased while the indices pTH10_Sys and pTH11_Sys reflect a reduction of dominant patterns. Bivariate indices (JSDdia29, JSDdia50, and JSDdia52; coupling between heart rate and diastolic blood pressure) were increased in POAG. The optimum set consisting of six parameters (JSDdia29, JSDdia58, pTH9_Sys, pW231, pW110_Sys and pW120_Sys) revealed a sensitivity of 83.3% and specificity of 80.6%. Conclusions. Nonlinear uni- and bivariate indices of continuous recordings of blood pressure and heart rate are altered in glaucoma. Abnormal blood pressure variability suggests disturbed autonomic regulation in patients with glaucoma.http://dx.doi.org/10.1155/2015/798958 |
| spellingShingle | Eva Charlotte Koch Johanna Staab Matthias Fuest Katharina Witt Andreas Voss Niklas Plange Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in Glaucoma Journal of Ophthalmology |
| title | Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in Glaucoma |
| title_full | Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in Glaucoma |
| title_fullStr | Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in Glaucoma |
| title_full_unstemmed | Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in Glaucoma |
| title_short | Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in Glaucoma |
| title_sort | blood pressure and heart rate variability to detect vascular dysregulation in glaucoma |
| url | http://dx.doi.org/10.1155/2015/798958 |
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