Small Molecules from Medicinal Plant <i>Iris tectorum</i> as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant <i>Escherichia coli</i>

Small Molecules from Medicinal Plant <i>Iris tectorum</i> as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant <i>Escherichia coli</i>

Background: Due to the widespread use of broad-spectrum antibiotics, the problem of antibiotic resistance has become an increasingly serious global threat. One of the key mechanisms of <i>Escherichia coli</i> resistance to beta-lactam antibiotics is the production of beta-lactamase enzym...

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Bibliographic Details
Main Authors: Youqi Ji, Yinhuan Wang, Zhangkai Xu, Danlei Chen, Zhendi Yu, Qingyi Shao, Xin Hong, Zishu Liu, Dongqing Cheng
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
<i>Iris tectorum</i>
<i>Escherichia coli</i>
β-lactam resistance
histidine kinase
phosphorylation
molecular docking
Online Access:https://www.mdpi.com/1420-3049/30/3/663
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