Optogenetic methods and technologies in solving applied medical problems
Optogenetics is an innovative and fast-growing field of science combining the advances in molecular biology and laser technologies to monitor various biochemical processes in the cell and to control its activity using light. Therefore, this review is devoted to the implementation of the optogenetic...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2020-07-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/2877 |
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| author | L. E. Sorokina V. I. Petrenko M. V. Subbotkin A. A. Kulanova A. S. Kucherenko A. V. Kubyshkin I. I. Fomochkina A. Yu. Nomerovskaya S. I. Halilov |
| author_facet | L. E. Sorokina V. I. Petrenko M. V. Subbotkin A. A. Kulanova A. S. Kucherenko A. V. Kubyshkin I. I. Fomochkina A. Yu. Nomerovskaya S. I. Halilov |
| author_sort | L. E. Sorokina |
| collection | DOAJ |
| description | Optogenetics is an innovative and fast-growing field of science combining the advances in molecular biology and laser technologies to monitor various biochemical processes in the cell and to control its activity using light. Therefore, this review is devoted to the implementation of the optogenetic approach to diagnosis and treatment of various socially sensitive diseases at the molecular and genetic level. Furthermore, the article considers different methods of delivery and incorporation of genetic constructs encoding transmembrane proteins. New fiber optic technologies used to develop implantable devices for generating and recording signals in excitable tissues are described. Besides, the most state-of-the-art and popular registration methods are considered in the review. |
| format | Article |
| id | doaj-art-72b745c922f44635872cc77d94bccf09 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-72b745c922f44635872cc77d94bccf092025-08-20T04:00:12ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842020-07-0119219520310.20538/1682-0363-2020-2-195-2031637Optogenetic methods and technologies in solving applied medical problemsL. E. Sorokina0V. I. Petrenko1M. V. Subbotkin2A. A. Kulanova3A. S. Kucherenko4A. V. Kubyshkin5I. I. Fomochkina6A. Yu. Nomerovskaya7S. I. Halilov8V.I. Vernadsky Crimean Federal University, Medical Academy named after S.I. GeorgievskyV.I. Vernadsky Crimean Federal University, Medical Academy named after S.I. GeorgievskyV.I. Vernadsky Crimean Federal University, Medical Academy named after S.I. GeorgievskyV.I. Vernadsky Crimean Federal University, Medical Academy named after S.I. GeorgievskyV.I. Vernadsky Crimean Federal University, Medical Academy named after S.I. GeorgievskyV.I. Vernadsky Crimean Federal University, Medical Academy named after S.I. GeorgievskyV.I. Vernadsky Crimean Federal University, Medical Academy named after S.I. GeorgievskyV.I. Vernadsky Crimean Federal University, Medical Academy named after S.I. GeorgievskyV.I. Vernadsky Crimean Federal University, Physics and Technology InstituteOptogenetics is an innovative and fast-growing field of science combining the advances in molecular biology and laser technologies to monitor various biochemical processes in the cell and to control its activity using light. Therefore, this review is devoted to the implementation of the optogenetic approach to diagnosis and treatment of various socially sensitive diseases at the molecular and genetic level. Furthermore, the article considers different methods of delivery and incorporation of genetic constructs encoding transmembrane proteins. New fiber optic technologies used to develop implantable devices for generating and recording signals in excitable tissues are described. Besides, the most state-of-the-art and popular registration methods are considered in the review.https://bulletin.ssmu.ru/jour/article/view/2877optogeneticsopsinsion channelsfiber optic systemsphotostimulationneurointerfaceoptogenetic therapy |
| spellingShingle | L. E. Sorokina V. I. Petrenko M. V. Subbotkin A. A. Kulanova A. S. Kucherenko A. V. Kubyshkin I. I. Fomochkina A. Yu. Nomerovskaya S. I. Halilov Optogenetic methods and technologies in solving applied medical problems Бюллетень сибирской медицины optogenetics opsins ion channels fiber optic systems photostimulation neurointerface optogenetic therapy |
| title | Optogenetic methods and technologies in solving applied medical problems |
| title_full | Optogenetic methods and technologies in solving applied medical problems |
| title_fullStr | Optogenetic methods and technologies in solving applied medical problems |
| title_full_unstemmed | Optogenetic methods and technologies in solving applied medical problems |
| title_short | Optogenetic methods and technologies in solving applied medical problems |
| title_sort | optogenetic methods and technologies in solving applied medical problems |
| topic | optogenetics opsins ion channels fiber optic systems photostimulation neurointerface optogenetic therapy |
| url | https://bulletin.ssmu.ru/jour/article/view/2877 |
| work_keys_str_mv | AT lesorokina optogeneticmethodsandtechnologiesinsolvingappliedmedicalproblems AT vipetrenko optogeneticmethodsandtechnologiesinsolvingappliedmedicalproblems AT mvsubbotkin optogeneticmethodsandtechnologiesinsolvingappliedmedicalproblems AT aakulanova optogeneticmethodsandtechnologiesinsolvingappliedmedicalproblems AT askucherenko optogeneticmethodsandtechnologiesinsolvingappliedmedicalproblems AT avkubyshkin optogeneticmethodsandtechnologiesinsolvingappliedmedicalproblems AT iifomochkina optogeneticmethodsandtechnologiesinsolvingappliedmedicalproblems AT ayunomerovskaya optogeneticmethodsandtechnologiesinsolvingappliedmedicalproblems AT sihalilov optogeneticmethodsandtechnologiesinsolvingappliedmedicalproblems |