High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibition
Abstract Background Porphyromonase gingivalis (P. gingivalis) is a type of bacteria that causes periodontitis, which is strongly correlated with systemic diseases such as diabetes. However, the effect of hyperglycemia on periodontitis are unclear. The present study examined the effects of high gluco...
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BMC
2024-10-01
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| Series: | BMC Immunology |
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| Online Access: | https://doi.org/10.1186/s12865-024-00655-7 |
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| author | Yuri Song Jin-Ju Kwon Hee Sam Na Si Yeong Kim Sang-Hun Shin Jin Chung |
| author_facet | Yuri Song Jin-Ju Kwon Hee Sam Na Si Yeong Kim Sang-Hun Shin Jin Chung |
| author_sort | Yuri Song |
| collection | DOAJ |
| description | Abstract Background Porphyromonase gingivalis (P. gingivalis) is a type of bacteria that causes periodontitis, which is strongly correlated with systemic diseases such as diabetes. However, the effect of hyperglycemia on periodontitis are unclear. The present study examined the effects of high glucose levels on the response to P. gingivalis infection. Results The expression of P. gingivalis-induced interleukin-1β (IL-1β) and inflammasomes increased as the glucose concentration increased. High glucose conditions suppressed P. gingivalis–induced autophagy in human acute monocytic leukemia cell line (THP-1) macrophages. Zingerone increased autophagy and alleviated P. gingivalis-induced inflammatory response in THP-1 macrophages under high glucose conditions. In addition, P. gingivalis- induced inflammation in bone marrow-derived macrophages of diabetic mice was higher than in wild-type mice, but a zingerone treatment decreased the levels. Alveolar bone loss due to a P. gingivalis infection was significantly higher in diabetic mice than in wild-type mice. Conclusions High-glucose conditions aggravated the inflammatory response to P. gingivalis infection by suppressing of autophagy, suggesting that autophagy induction could potentially to treat periodontitis in diabetes. Zingerone has potential use as a treatment for periodontal inflammation induced by P. gingivalis in diabetes patients. |
| format | Article |
| id | doaj-art-72b5a8cf70454cd898bde49fb482b4ba |
| institution | OA Journals |
| issn | 1471-2172 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj-art-72b5a8cf70454cd898bde49fb482b4ba2025-08-20T02:17:40ZengBMCBMC Immunology1471-21722024-10-012511910.1186/s12865-024-00655-7High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibitionYuri Song0Jin-Ju Kwon1Hee Sam Na2Si Yeong Kim3Sang-Hun Shin4Jin Chung5Oral Genomics Research Center, Pusan National UniversityDepartment of Dentistry, Yeungnam University College of MedicineOral Genomics Research Center, Pusan National UniversityOral Genomics Research Center, Pusan National UniversityDepartment of Oral and Maxillofacial Surgery, Dental Research Institute, Pusan National University Dental HospitalOral Genomics Research Center, Pusan National UniversityAbstract Background Porphyromonase gingivalis (P. gingivalis) is a type of bacteria that causes periodontitis, which is strongly correlated with systemic diseases such as diabetes. However, the effect of hyperglycemia on periodontitis are unclear. The present study examined the effects of high glucose levels on the response to P. gingivalis infection. Results The expression of P. gingivalis-induced interleukin-1β (IL-1β) and inflammasomes increased as the glucose concentration increased. High glucose conditions suppressed P. gingivalis–induced autophagy in human acute monocytic leukemia cell line (THP-1) macrophages. Zingerone increased autophagy and alleviated P. gingivalis-induced inflammatory response in THP-1 macrophages under high glucose conditions. In addition, P. gingivalis- induced inflammation in bone marrow-derived macrophages of diabetic mice was higher than in wild-type mice, but a zingerone treatment decreased the levels. Alveolar bone loss due to a P. gingivalis infection was significantly higher in diabetic mice than in wild-type mice. Conclusions High-glucose conditions aggravated the inflammatory response to P. gingivalis infection by suppressing of autophagy, suggesting that autophagy induction could potentially to treat periodontitis in diabetes. Zingerone has potential use as a treatment for periodontal inflammation induced by P. gingivalis in diabetes patients.https://doi.org/10.1186/s12865-024-00655-7AutophagyHyperglycaemiaInflammationPeriodontitisPorphyromonase gingivalis |
| spellingShingle | Yuri Song Jin-Ju Kwon Hee Sam Na Si Yeong Kim Sang-Hun Shin Jin Chung High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibition BMC Immunology Autophagy Hyperglycaemia Inflammation Periodontitis Porphyromonase gingivalis |
| title | High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibition |
| title_full | High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibition |
| title_fullStr | High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibition |
| title_full_unstemmed | High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibition |
| title_short | High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibition |
| title_sort | high glucose condition aggravates inflammatory response induced by porphyromonas gingivalis in thp 1 macrophages via autophagy inhibition |
| topic | Autophagy Hyperglycaemia Inflammation Periodontitis Porphyromonase gingivalis |
| url | https://doi.org/10.1186/s12865-024-00655-7 |
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