Transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imaging
Abstract Here, we report the fabrication of transparent multichannel vertical nanotube electrode arrays for detecting cellular activity and optically imaging neuronal networks. To fabricate these transparent electrode arrays, position- and morphology-controlled ZnO nanotube arrays consisting of ultr...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | NPG Asia Materials |
| Online Access: | https://doi.org/10.1038/s41427-024-00532-0 |
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| _version_ | 1832594625896906752 |
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| author | Jamin Lee Keundong Lee Kyumeen Kang Asad Ali Dong Wook Kim Hyerim Ahn Gwanho Ko Myunghwan Choi Youngbin Tchoe Hye Yoon Park Gyu-Chul Yi |
| author_facet | Jamin Lee Keundong Lee Kyumeen Kang Asad Ali Dong Wook Kim Hyerim Ahn Gwanho Ko Myunghwan Choi Youngbin Tchoe Hye Yoon Park Gyu-Chul Yi |
| author_sort | Jamin Lee |
| collection | DOAJ |
| description | Abstract Here, we report the fabrication of transparent multichannel vertical nanotube electrode arrays for detecting cellular activity and optically imaging neuronal networks. To fabricate these transparent electrode arrays, position- and morphology-controlled ZnO nanotube arrays consisting of ultrathin nanowalls were grown on transparent graphene layers and coated with Ti/Au metal layers. Using these multichannel arrays, electrophysiological signals were individually recorded from primary mouse hippocampal neurons and recorded distinctive intracellular potential-like signals. Moreover, the transparent electrode array enabled fluorescence imaging of neuron cell bodies and neurite connections. This transparent graphene- and nanotube-based recording device is proposed to greatly increase the versatility of capabilities for investigating neuronal activity through simultaneous recording and imaging of neuron cultures. |
| format | Article |
| id | doaj-art-72b503c27abd4235ab3d3e5c4b4d2810 |
| institution | Kabale University |
| issn | 1884-4057 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | NPG Asia Materials |
| spelling | doaj-art-72b503c27abd4235ab3d3e5c4b4d28102025-01-19T12:28:59ZengNature PortfolioNPG Asia Materials1884-40572024-03-011611910.1038/s41427-024-00532-0Transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imagingJamin Lee0Keundong Lee1Kyumeen Kang2Asad Ali3Dong Wook Kim4Hyerim Ahn5Gwanho Ko6Myunghwan Choi7Youngbin Tchoe8Hye Yoon Park9Gyu-Chul Yi10Interdisciplinary Program in Neuroscience, College of Science, Seoul National UniversityIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San DiegoInterdisciplinary Program in Neuroscience, College of Science, Seoul National UniversityCenter for Novel Epitaxial Quantum Architectures, Department of Physics and Astronomy, Seoul National UniversityCenter for Novel Epitaxial Quantum Architectures, Department of Physics and Astronomy, Seoul National UniversityDepartment of Electrical and Computer Engineering, University of MinnesotaSchool of Biological Sciences, Seoul National UniversitySchool of Biological Sciences, Seoul National UniversityDepartment of Biomedical Engineering, Ulsan National Institute of Science and TechnologyDepartment of Electrical and Computer Engineering, University of MinnesotaInterdisciplinary Program in Neuroscience, College of Science, Seoul National UniversityAbstract Here, we report the fabrication of transparent multichannel vertical nanotube electrode arrays for detecting cellular activity and optically imaging neuronal networks. To fabricate these transparent electrode arrays, position- and morphology-controlled ZnO nanotube arrays consisting of ultrathin nanowalls were grown on transparent graphene layers and coated with Ti/Au metal layers. Using these multichannel arrays, electrophysiological signals were individually recorded from primary mouse hippocampal neurons and recorded distinctive intracellular potential-like signals. Moreover, the transparent electrode array enabled fluorescence imaging of neuron cell bodies and neurite connections. This transparent graphene- and nanotube-based recording device is proposed to greatly increase the versatility of capabilities for investigating neuronal activity through simultaneous recording and imaging of neuron cultures.https://doi.org/10.1038/s41427-024-00532-0 |
| spellingShingle | Jamin Lee Keundong Lee Kyumeen Kang Asad Ali Dong Wook Kim Hyerim Ahn Gwanho Ko Myunghwan Choi Youngbin Tchoe Hye Yoon Park Gyu-Chul Yi Transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imaging NPG Asia Materials |
| title | Transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imaging |
| title_full | Transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imaging |
| title_fullStr | Transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imaging |
| title_full_unstemmed | Transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imaging |
| title_short | Transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imaging |
| title_sort | transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imaging |
| url | https://doi.org/10.1038/s41427-024-00532-0 |
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