Diagnosis and management of TFE3-rearranged renal cell carcinoma: case report and literature review
Abstract Background TFE3-rearranged renal cell carcinoma is a rare malignancy with distinctive morphological and immunological characteristics. Although it can manifest in individuals of any age, its occurrence in adults is exceedingly uncommon, comprising only 1.5% of adult renal cell carcinomas. T...
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| Language: | English |
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2025-08-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-025-01908-2 |
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| author | Yongxin Zhang Junxin Shen Jinfeng Wu Hongxing Huang Fengjiao Meng Runqiang Yuan Yangbai Lu |
| author_facet | Yongxin Zhang Junxin Shen Jinfeng Wu Hongxing Huang Fengjiao Meng Runqiang Yuan Yangbai Lu |
| author_sort | Yongxin Zhang |
| collection | DOAJ |
| description | Abstract Background TFE3-rearranged renal cell carcinoma is a rare malignancy with distinctive morphological and immunological characteristics. Although it can manifest in individuals of any age, its occurrence in adults is exceedingly uncommon, comprising only 1.5% of adult renal cell carcinomas. The disease typically presents with a benign course in pediatric patients, yet in adults, it often progresses rapidly and aggressively. Case presentation Herein, we present a case of a 35-year-old female diagnosed with TFE3-rearranged renal cell carcinoma, who was initially asymptomatic. Imaging studies revealed a solid renal mass in the left kidney without signs of metastasis. Initially misdiagnosed as a vascular smooth muscle lipoma, the patient underwent laparoscopic partial nephrectomy. Subsequent histopathological and molecular analyses validated the diagnosis of TFE3-rearranged renal cell carcinoma. The patient demonstrated favorable short-term outcomes after early laparoscopic intervention, with no evidence of tumor recurrence or metastasis at both the 4-month and 15-month follow-ups. Conclusions This case serves as a valuable resource for oncologists involved in the diagnosis and management of TFE3-rearranged renal cell carcinoma. |
| format | Article |
| id | doaj-art-72a81a426ee449e68672db6fec8bea74 |
| institution | Kabale University |
| issn | 1471-2490 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj-art-72a81a426ee449e68672db6fec8bea742025-08-24T11:53:10ZengBMCBMC Urology1471-24902025-08-012511710.1186/s12894-025-01908-2Diagnosis and management of TFE3-rearranged renal cell carcinoma: case report and literature reviewYongxin Zhang0Junxin Shen1Jinfeng Wu2Hongxing Huang3Fengjiao Meng4Runqiang Yuan5Yangbai Lu6Department of MR, Zhongshan City People’s HospitalDepartment of First Clinical Medical College, Guangdong Medical UniversityDepartment of First Clinical Medical College, Guangdong Medical UniversityDepartment of First Clinical Medical College, Guangdong Medical UniversityDepartment of Pathology, Zhongshan City People’s HospitalDepartment of Urology, Zhongshan City People’s HospitalDepartment of Urology, Zhongshan City People’s HospitalAbstract Background TFE3-rearranged renal cell carcinoma is a rare malignancy with distinctive morphological and immunological characteristics. Although it can manifest in individuals of any age, its occurrence in adults is exceedingly uncommon, comprising only 1.5% of adult renal cell carcinomas. The disease typically presents with a benign course in pediatric patients, yet in adults, it often progresses rapidly and aggressively. Case presentation Herein, we present a case of a 35-year-old female diagnosed with TFE3-rearranged renal cell carcinoma, who was initially asymptomatic. Imaging studies revealed a solid renal mass in the left kidney without signs of metastasis. Initially misdiagnosed as a vascular smooth muscle lipoma, the patient underwent laparoscopic partial nephrectomy. Subsequent histopathological and molecular analyses validated the diagnosis of TFE3-rearranged renal cell carcinoma. The patient demonstrated favorable short-term outcomes after early laparoscopic intervention, with no evidence of tumor recurrence or metastasis at both the 4-month and 15-month follow-ups. Conclusions This case serves as a valuable resource for oncologists involved in the diagnosis and management of TFE3-rearranged renal cell carcinoma.https://doi.org/10.1186/s12894-025-01908-2ImmunohistochemistryRenal cell carcinomaTFE3PathologyPrognosis |
| spellingShingle | Yongxin Zhang Junxin Shen Jinfeng Wu Hongxing Huang Fengjiao Meng Runqiang Yuan Yangbai Lu Diagnosis and management of TFE3-rearranged renal cell carcinoma: case report and literature review BMC Urology Immunohistochemistry Renal cell carcinoma TFE3 Pathology Prognosis |
| title | Diagnosis and management of TFE3-rearranged renal cell carcinoma: case report and literature review |
| title_full | Diagnosis and management of TFE3-rearranged renal cell carcinoma: case report and literature review |
| title_fullStr | Diagnosis and management of TFE3-rearranged renal cell carcinoma: case report and literature review |
| title_full_unstemmed | Diagnosis and management of TFE3-rearranged renal cell carcinoma: case report and literature review |
| title_short | Diagnosis and management of TFE3-rearranged renal cell carcinoma: case report and literature review |
| title_sort | diagnosis and management of tfe3 rearranged renal cell carcinoma case report and literature review |
| topic | Immunohistochemistry Renal cell carcinoma TFE3 Pathology Prognosis |
| url | https://doi.org/10.1186/s12894-025-01908-2 |
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