Research progress of immune checkpoint inhibitors in the treatment of glioblastoma
Glioblastoma (GBM) is the most invasive glioma in the central nervous system. Maximum surgical resection, chemotherapy and radiotherapy are currently the standard treatment for GBM. Due to the unique immune environment of the central nervous system, the application of immunotherapy in GBM is facing...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of New Medicine
2024-05-01
|
| Series: | Yixue xinzhi zazhi |
| Subjects: | |
| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2406/o9E7MrjityHk2SeTlTyNYq8BAgyYODRSNIvoRLZ3.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850243327675334656 |
|---|---|
| author | JIA Xiaorong ZHANG Gong |
| author_facet | JIA Xiaorong ZHANG Gong |
| author_sort | JIA Xiaorong |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most invasive glioma in the central nervous system. Maximum surgical resection, chemotherapy and radiotherapy are currently the standard treatment for GBM. Due to the unique immune environment of the central nervous system, the application of immunotherapy in GBM is facing challenges. Immune checkpoint inhibitors (ICIs) is one of the main immunotherapy strategies for GBM. Clarifying the mechanism of ICIs in GBM and developing effective therapeutic targets are of great significance to prolong the survival of GBM patients. In the study, we summarize the research progress of blood-brain barrier, tumor microenvironment, immune cells, ICIs and their combination therapy in GBM to provide reference for GBM immunotherapy. |
| format | Article |
| id | doaj-art-72a72f5c02d54fbf889a64fe5d79bf1c |
| institution | OA Journals |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2024-05-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-72a72f5c02d54fbf889a64fe5d79bf1c2025-08-20T02:00:01ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112024-05-0134559360210.12173/j.issn.1004-5511.2024010926491Research progress of immune checkpoint inhibitors in the treatment of glioblastomaJIA XiaorongZHANG GongGlioblastoma (GBM) is the most invasive glioma in the central nervous system. Maximum surgical resection, chemotherapy and radiotherapy are currently the standard treatment for GBM. Due to the unique immune environment of the central nervous system, the application of immunotherapy in GBM is facing challenges. Immune checkpoint inhibitors (ICIs) is one of the main immunotherapy strategies for GBM. Clarifying the mechanism of ICIs in GBM and developing effective therapeutic targets are of great significance to prolong the survival of GBM patients. In the study, we summarize the research progress of blood-brain barrier, tumor microenvironment, immune cells, ICIs and their combination therapy in GBM to provide reference for GBM immunotherapy.https://yxxz.whuznhmedj.com/futureApi/storage/attach/2406/o9E7MrjityHk2SeTlTyNYq8BAgyYODRSNIvoRLZ3.pdfglioblastomaimmunotherapyimmunocyteimmune checkpoint inhibitors |
| spellingShingle | JIA Xiaorong ZHANG Gong Research progress of immune checkpoint inhibitors in the treatment of glioblastoma Yixue xinzhi zazhi glioblastoma immunotherapy immunocyte immune checkpoint inhibitors |
| title | Research progress of immune checkpoint inhibitors in the treatment of glioblastoma |
| title_full | Research progress of immune checkpoint inhibitors in the treatment of glioblastoma |
| title_fullStr | Research progress of immune checkpoint inhibitors in the treatment of glioblastoma |
| title_full_unstemmed | Research progress of immune checkpoint inhibitors in the treatment of glioblastoma |
| title_short | Research progress of immune checkpoint inhibitors in the treatment of glioblastoma |
| title_sort | research progress of immune checkpoint inhibitors in the treatment of glioblastoma |
| topic | glioblastoma immunotherapy immunocyte immune checkpoint inhibitors |
| url | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2406/o9E7MrjityHk2SeTlTyNYq8BAgyYODRSNIvoRLZ3.pdf |
| work_keys_str_mv | AT jiaxiaorong researchprogressofimmunecheckpointinhibitorsinthetreatmentofglioblastoma AT zhanggong researchprogressofimmunecheckpointinhibitorsinthetreatmentofglioblastoma |