Gut microbial dysbiosis, IgA, and Enterococcus in common variable immunodeficiency with immune dysregulation

Gut microbial dysbiosis, IgA, and Enterococcus in common variable immunodeficiency with immune dysregulation

Abstract Background Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and recurrent infections. Significant morbidity and mortality are caused by immune dysregulation complications (CVIDid), which affect around one-third of CVID patients and have a poorly understood e...

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Main Authors: Roos-Marijn Berbers, Fernanda L. Paganelli, Joris M. van Montfrans, Pauline M. Ellerbroek, Marco C. Viveen, Malbert R. C. Rogers, Moniek Salomons, Jaap Schuurmans, Martine van Stigt Thans, Remi M. M. Vanmaris, Lodewijk A. A. Brosens, Maria Marlot van der Wal, Virgil A. S. H. Dalm, P. Martin van Hagen, Annick A. J. M. van de Ven, Hae-Won Uh, Femke van Wijk, Rob J. L. Willems, Helen L. Leavis
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Microbiome
Subjects:
Common variable immunodeficiency (CVID)
Immune dysregulation
Gut microbiota
Pathobionts
Online Access:https://doi.org/10.1186/s40168-024-01982-y
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