Efficacy and safety of chimeric antigen receptor T cells targeting BCMA and GPRC5D in relapsed or refractory multiple myeloma

Efficacy and safety of chimeric antigen receptor T cells targeting BCMA and GPRC5D in relapsed or refractory multiple myeloma

BackgroundClinical studies have demonstrated the high efficacy of using chimeric antigen receptor (CAR)-T cells targeting B-cell maturation antigen (BCMA) and orphan G protein-coupled receptor, class C group 5 member D (GPRC5D) to treat relapsed or refractory multiple myeloma (RRMM). In this study,...

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Bibliographic Details
Main Authors: Xu Yang, Feiqing Wang, Xiaoshuang Yuan, Bo Yang, Juan Chen, Jinyang Cheng, Guangyang Liu, Dongxin Tang, Xiao Xu, Sanbin Wang, Zhixu He, Yang Liu, Yanju Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
B-cell maturation antigen
G protein-coupled receptor
class C group 5 member D
car-T
relapsed or refractory multiple myeloma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1466443/full
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