NT-proCNP as a new biomarker of pulmonary hypertension in patients with COPD
Abstract To assess N-Terminal Pro C-Type Natriuretic Peptide (NT-proCNP) plasma levels in patients with chronic obstructive pulmonary disease (COPD) and evaluate of its diagnostic value for pulmonary hypertension (PH) in COPD. According to the range of systolic pulmonary artery pressure (SPAP), the...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-08059-2 |
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| author | Sergey N. Avdeev Viliya V. Gaynitdinova Zamira M. Merzhoeva Galiya S. Nuralieva Evgeniy A. Tarabrin Zelimkhan G. Berikkhanov Lidiya Y. Nikitina Tatiana Y. Gneusheva Elizaveta S. Sokolova Rifat M. Ainetdinov Anna A. Proshkina Kirill S. Ataman Qingyun Ma |
| author_facet | Sergey N. Avdeev Viliya V. Gaynitdinova Zamira M. Merzhoeva Galiya S. Nuralieva Evgeniy A. Tarabrin Zelimkhan G. Berikkhanov Lidiya Y. Nikitina Tatiana Y. Gneusheva Elizaveta S. Sokolova Rifat M. Ainetdinov Anna A. Proshkina Kirill S. Ataman Qingyun Ma |
| author_sort | Sergey N. Avdeev |
| collection | DOAJ |
| description | Abstract To assess N-Terminal Pro C-Type Natriuretic Peptide (NT-proCNP) plasma levels in patients with chronic obstructive pulmonary disease (COPD) and evaluate of its diagnostic value for pulmonary hypertension (PH) in COPD. According to the range of systolic pulmonary artery pressure (SPAP), the COPD patients were divided into group of patients without PH (SPAP < 40 mmHg, n = 42) and group of patients with PH (SPAP ≥40 mmHg, n = 52). Significant differences in NT-proCNP levels were found in patients with and without PH (3.63 ± 0.95 pg/mL vs. 1.42 ± 0.35 pg/mL, p < 0.001). Statistically significant correlations were shown between NT-proCNP levels and SPAP (r = 0.77, p < 0.001), mMRC dyspnea score (r = 0.42, p = 0.001), CAT score (r = 0.60, p < 0.001), and SpO2 (r = − 0.47, p = 0.001). Pulmonary hypertension in COPD patients was associated with higher plasma NT-proCNP levels. |
| format | Article |
| id | doaj-art-72986cede1e448fc8b897c3c7e529c72 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-72986cede1e448fc8b897c3c7e529c722025-08-20T03:37:22ZengNature PortfolioScientific Reports2045-23222025-07-011511710.1038/s41598-025-08059-2NT-proCNP as a new biomarker of pulmonary hypertension in patients with COPDSergey N. Avdeev0Viliya V. Gaynitdinova1Zamira M. Merzhoeva2Galiya S. Nuralieva3Evgeniy A. Tarabrin4Zelimkhan G. Berikkhanov5Lidiya Y. Nikitina6Tatiana Y. Gneusheva7Elizaveta S. Sokolova8Rifat M. Ainetdinov9Anna A. Proshkina10Kirill S. Ataman11Qingyun Ma12Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University)Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University)Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University)Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University)Department of hospital surgery No.2, I.M. Sechenov First Moscow State Medical University (Sechenov University)National Medical Research Center of Pulmonology, I.M. Sechenov First, Moscow State Medical University (Sechenov University)National Medical Research Center of Pulmonology, I.M. Sechenov First, Moscow State Medical University (Sechenov University)Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University)Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University)National Medical Research Center of Pulmonology, I.M. Sechenov First, Moscow State Medical University (Sechenov University)Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University)Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University)Department of hospital surgery No.2, I.M. Sechenov First Moscow State Medical University (Sechenov University)Abstract To assess N-Terminal Pro C-Type Natriuretic Peptide (NT-proCNP) plasma levels in patients with chronic obstructive pulmonary disease (COPD) and evaluate of its diagnostic value for pulmonary hypertension (PH) in COPD. According to the range of systolic pulmonary artery pressure (SPAP), the COPD patients were divided into group of patients without PH (SPAP < 40 mmHg, n = 42) and group of patients with PH (SPAP ≥40 mmHg, n = 52). Significant differences in NT-proCNP levels were found in patients with and without PH (3.63 ± 0.95 pg/mL vs. 1.42 ± 0.35 pg/mL, p < 0.001). Statistically significant correlations were shown between NT-proCNP levels and SPAP (r = 0.77, p < 0.001), mMRC dyspnea score (r = 0.42, p = 0.001), CAT score (r = 0.60, p < 0.001), and SpO2 (r = − 0.47, p = 0.001). Pulmonary hypertension in COPD patients was associated with higher plasma NT-proCNP levels.https://doi.org/10.1038/s41598-025-08059-2Chronic obstructive pulmonary diseasePulmonary hypertensionBiomarkers, NT-proCNP |
| spellingShingle | Sergey N. Avdeev Viliya V. Gaynitdinova Zamira M. Merzhoeva Galiya S. Nuralieva Evgeniy A. Tarabrin Zelimkhan G. Berikkhanov Lidiya Y. Nikitina Tatiana Y. Gneusheva Elizaveta S. Sokolova Rifat M. Ainetdinov Anna A. Proshkina Kirill S. Ataman Qingyun Ma NT-proCNP as a new biomarker of pulmonary hypertension in patients with COPD Scientific Reports Chronic obstructive pulmonary disease Pulmonary hypertension Biomarkers, NT-proCNP |
| title | NT-proCNP as a new biomarker of pulmonary hypertension in patients with COPD |
| title_full | NT-proCNP as a new biomarker of pulmonary hypertension in patients with COPD |
| title_fullStr | NT-proCNP as a new biomarker of pulmonary hypertension in patients with COPD |
| title_full_unstemmed | NT-proCNP as a new biomarker of pulmonary hypertension in patients with COPD |
| title_short | NT-proCNP as a new biomarker of pulmonary hypertension in patients with COPD |
| title_sort | nt procnp as a new biomarker of pulmonary hypertension in patients with copd |
| topic | Chronic obstructive pulmonary disease Pulmonary hypertension Biomarkers, NT-proCNP |
| url | https://doi.org/10.1038/s41598-025-08059-2 |
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