MicroRNA-mediated regulation of BCL-2 in breast cancer
Breast cancer, a prominent form of cancer in women, arises from the inner lining of mammary glands, ducts, and lobules. With an approximate prevalence rate of 1 in 8 women, the standard treatment methods for this condition include the surgical excision of afflicted tissues, chemotherapy, radiation,...
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AIMS Press
2025-01-01
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| Series: | AIMS Molecular Science |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/molsci.2025003 |
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| author | Kannan Mayuri Sundaram Vickram Thirunavukarasou Anand Konda Mani Saravanan |
| author_facet | Kannan Mayuri Sundaram Vickram Thirunavukarasou Anand Konda Mani Saravanan |
| author_sort | Kannan Mayuri |
| collection | DOAJ |
| description | Breast cancer, a prominent form of cancer in women, arises from the inner lining of mammary glands, ducts, and lobules. With an approximate prevalence rate of 1 in 8 women, the standard treatment methods for this condition include the surgical excision of afflicted tissues, chemotherapy, radiation, and hormone therapy. The BCL-2 gene, also known as the B cell lymphoma gene, prevents apoptosis in eukaryotic cells. It is commonly found to be excessively active in many types of malignancies, such as leukemia, carcinomas, and breast cancer. The excessive expression of this gene has a role in the advancement of cancer by inhibiting apoptosis. Recent research emphasizes the function of microRNAs (miRs) in regulating the expression of BCL-2. These miRs can either decrease or increase the activity of specific genes involved in programmed cell death, thus making them potential targets for therapeutic interventions. This review explicitly examines the regulatory impacts of several miRs on BCL-2, thereby investigating their ability to trigger apoptosis and function as targeted treatments for breast cancer. By comprehending the complex interplay between miRs and BCL-2, it is possible to devise novel therapeutic approaches that can augment the efficacy of breast cancer treatments, thus eventually enhancing patient outcomes. |
| format | Article |
| id | doaj-art-7296b2a255db49a2a1166bd33a61353c |
| institution | OA Journals |
| issn | 2372-0301 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj-art-7296b2a255db49a2a1166bd33a61353c2025-08-20T02:34:12ZengAIMS PressAIMS Molecular Science2372-03012025-01-01121324810.3934/molsci.2025003MicroRNA-mediated regulation of BCL-2 in breast cancerKannan Mayuri0Sundaram Vickram1Thirunavukarasou Anand2Konda Mani Saravanan3Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai 602105, Tamil Nadu, IndiaDepartment of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai 602105, Tamil Nadu, IndiaSRIIC Lab, Faculty of Clinical Research, Sri Ramachandra Institute of Higher Education and Research, Chennai 600116, Tamil Nadu, IndiaDepartment of Biotechnology, Bharath Institute of Higher Education and Research, Chennai 600073, Tamil Nadu, IndiaBreast cancer, a prominent form of cancer in women, arises from the inner lining of mammary glands, ducts, and lobules. With an approximate prevalence rate of 1 in 8 women, the standard treatment methods for this condition include the surgical excision of afflicted tissues, chemotherapy, radiation, and hormone therapy. The BCL-2 gene, also known as the B cell lymphoma gene, prevents apoptosis in eukaryotic cells. It is commonly found to be excessively active in many types of malignancies, such as leukemia, carcinomas, and breast cancer. The excessive expression of this gene has a role in the advancement of cancer by inhibiting apoptosis. Recent research emphasizes the function of microRNAs (miRs) in regulating the expression of BCL-2. These miRs can either decrease or increase the activity of specific genes involved in programmed cell death, thus making them potential targets for therapeutic interventions. This review explicitly examines the regulatory impacts of several miRs on BCL-2, thereby investigating their ability to trigger apoptosis and function as targeted treatments for breast cancer. By comprehending the complex interplay between miRs and BCL-2, it is possible to devise novel therapeutic approaches that can augment the efficacy of breast cancer treatments, thus eventually enhancing patient outcomes.https://www.aimspress.com/article/doi/10.3934/molsci.2025003oncologymirbcl-2 genebreast cancertargeted therapy |
| spellingShingle | Kannan Mayuri Sundaram Vickram Thirunavukarasou Anand Konda Mani Saravanan MicroRNA-mediated regulation of BCL-2 in breast cancer AIMS Molecular Science oncology mir bcl-2 gene breast cancer targeted therapy |
| title | MicroRNA-mediated regulation of BCL-2 in breast cancer |
| title_full | MicroRNA-mediated regulation of BCL-2 in breast cancer |
| title_fullStr | MicroRNA-mediated regulation of BCL-2 in breast cancer |
| title_full_unstemmed | MicroRNA-mediated regulation of BCL-2 in breast cancer |
| title_short | MicroRNA-mediated regulation of BCL-2 in breast cancer |
| title_sort | microrna mediated regulation of bcl 2 in breast cancer |
| topic | oncology mir bcl-2 gene breast cancer targeted therapy |
| url | https://www.aimspress.com/article/doi/10.3934/molsci.2025003 |
| work_keys_str_mv | AT kannanmayuri micrornamediatedregulationofbcl2inbreastcancer AT sundaramvickram micrornamediatedregulationofbcl2inbreastcancer AT thirunavukarasouanand micrornamediatedregulationofbcl2inbreastcancer AT kondamanisaravanan micrornamediatedregulationofbcl2inbreastcancer |