Predictive value of neutrophil-to-lymphocyte ratio for long-term adverse outcomes in cirrhosis patients post-transjugular intrahepatic portosystemic shunt
Abstract The neutrophil-to-lymphocyte ratio (NLR) may predict outcomes in end-stage liver disease, but its value after transjugular intrahepatic portosystemic shunt (TIPS) is unclear. This study explored the link between NLR and long-term outcomes in decompensated cirrhosis patients post-TIPS. We re...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84630-7 |
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| author | Qian Zhang Zi Xu Li Long Xinhua Luo Rongpin Wang Kangshun Zhu |
| author_facet | Qian Zhang Zi Xu Li Long Xinhua Luo Rongpin Wang Kangshun Zhu |
| author_sort | Qian Zhang |
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| description | Abstract The neutrophil-to-lymphocyte ratio (NLR) may predict outcomes in end-stage liver disease, but its value after transjugular intrahepatic portosystemic shunt (TIPS) is unclear. This study explored the link between NLR and long-term outcomes in decompensated cirrhosis patients post-TIPS. We retrospectively analyzed 184 patients treated between January 2016 and December 2021, noting demographic data, lab results, and follow-up outcomes, including liver transplantation or death. Cox regression, adjusted for various factors, showed that NLR is an independent predictor of post-TIPS progression (HR 1.665; 95% CI 1.149–2.414; P = 0.007). Patients were divided into tertiles based on NLR. The medium tertile had a 3.51-fold increased risk of progression compared to the lowest (HR 3.510; 95% CI 1.104–11.153, P = 0.033), and the highest tertile had a 5.112-fold increase (HR 5.112; 95% CI 1.653–15.806, P = 0.005). This suggests that NLR is a valuable prognostic marker for long-term progression in these patients, highlighting the role of systemic inflammation. |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-729633b9c595413e852f61a6d6da40372025-01-05T12:21:41ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-024-84630-7Predictive value of neutrophil-to-lymphocyte ratio for long-term adverse outcomes in cirrhosis patients post-transjugular intrahepatic portosystemic shuntQian Zhang0Zi Xu1Li Long2Xinhua Luo3Rongpin Wang4Kangshun Zhu5Department of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital of Guangzhou Medical UniversityDepartment of Radiology, Guizhou Provincial People’ s HospitalDepartment of Infectious Diseases, Guizhou Provincial People’ s HospitalDepartment of Infectious Diseases, Guizhou Provincial People’ s HospitalDepartment of Radiology, Guizhou Provincial People’ s HospitalDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital of Guangzhou Medical UniversityAbstract The neutrophil-to-lymphocyte ratio (NLR) may predict outcomes in end-stage liver disease, but its value after transjugular intrahepatic portosystemic shunt (TIPS) is unclear. This study explored the link between NLR and long-term outcomes in decompensated cirrhosis patients post-TIPS. We retrospectively analyzed 184 patients treated between January 2016 and December 2021, noting demographic data, lab results, and follow-up outcomes, including liver transplantation or death. Cox regression, adjusted for various factors, showed that NLR is an independent predictor of post-TIPS progression (HR 1.665; 95% CI 1.149–2.414; P = 0.007). Patients were divided into tertiles based on NLR. The medium tertile had a 3.51-fold increased risk of progression compared to the lowest (HR 3.510; 95% CI 1.104–11.153, P = 0.033), and the highest tertile had a 5.112-fold increase (HR 5.112; 95% CI 1.653–15.806, P = 0.005). This suggests that NLR is a valuable prognostic marker for long-term progression in these patients, highlighting the role of systemic inflammation.https://doi.org/10.1038/s41598-024-84630-7Neutrophil-to-lymphocyte ratioTransjugular intrahepatic portosystemic shuntPrognosisCirrhosisPredictive |
| spellingShingle | Qian Zhang Zi Xu Li Long Xinhua Luo Rongpin Wang Kangshun Zhu Predictive value of neutrophil-to-lymphocyte ratio for long-term adverse outcomes in cirrhosis patients post-transjugular intrahepatic portosystemic shunt Scientific Reports Neutrophil-to-lymphocyte ratio Transjugular intrahepatic portosystemic shunt Prognosis Cirrhosis Predictive |
| title | Predictive value of neutrophil-to-lymphocyte ratio for long-term adverse outcomes in cirrhosis patients post-transjugular intrahepatic portosystemic shunt |
| title_full | Predictive value of neutrophil-to-lymphocyte ratio for long-term adverse outcomes in cirrhosis patients post-transjugular intrahepatic portosystemic shunt |
| title_fullStr | Predictive value of neutrophil-to-lymphocyte ratio for long-term adverse outcomes in cirrhosis patients post-transjugular intrahepatic portosystemic shunt |
| title_full_unstemmed | Predictive value of neutrophil-to-lymphocyte ratio for long-term adverse outcomes in cirrhosis patients post-transjugular intrahepatic portosystemic shunt |
| title_short | Predictive value of neutrophil-to-lymphocyte ratio for long-term adverse outcomes in cirrhosis patients post-transjugular intrahepatic portosystemic shunt |
| title_sort | predictive value of neutrophil to lymphocyte ratio for long term adverse outcomes in cirrhosis patients post transjugular intrahepatic portosystemic shunt |
| topic | Neutrophil-to-lymphocyte ratio Transjugular intrahepatic portosystemic shunt Prognosis Cirrhosis Predictive |
| url | https://doi.org/10.1038/s41598-024-84630-7 |
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