Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided analysis.

Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided analysis.

Immune checkpoint inhibition (ICI) has emerged as a critical treatment strategy for squamous cell carcinoma of the head and neck (HNSCC) that halts the immune escape of the tumor cells. Increasing evidence suggests that the onset, progression, and lack of/no response of HNSCC to ICI are emergent pro...

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Main Authors: Priyan Bhattacharya, Alban Linnenbach, Andrew P South, Ubaldo Martinez-Outschoorn, Joseph M Curry, Jennifer M Johnson, Larry A Harshyne, Mỹ G Mahoney, Adam J Luginbuhl, Rajanikanth Vadigepalli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1013127
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