Non-invasive therapeutics for neurotrauma: a mechanistic overview
Traumatic brain injury is a leading cause of death and a major risk factor for the development of both memory and motor disorders. To date, there are no proven interventions to improve patient outcome after neurotrauma. A promising avenue of treatment has emerged in the use of non-invasive therapies...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1560777/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850032584609759232 |
|---|---|
| author | James D. O'Leary Bevan S. Main Mark P. Burns |
| author_facet | James D. O'Leary Bevan S. Main Mark P. Burns |
| author_sort | James D. O'Leary |
| collection | DOAJ |
| description | Traumatic brain injury is a leading cause of death and a major risk factor for the development of both memory and motor disorders. To date, there are no proven interventions to improve patient outcome after neurotrauma. A promising avenue of treatment has emerged in the use of non-invasive therapies for recovery after brain injury. A number of non-invasive brain stimulation techniques have been developed, such as transcranial direct current stimulation, transcranial magnetic stimulation and vagus nerve stimulation, as well as low intensity ultrasound stimulation and photobiomodulation therapy. However, standardized treatment regimens have not been developed. There is a clear need to better understand the underlying mechanisms of non-invasive therapeutics on brain injury pathology so as to more effectively guide treatment strategy. Here we review the current literature of non-invasive therapies in preclinical neurotrauma and offer insight into the potential mechanism of action and novel targets for the treatment of traumatic brain injury. |
| format | Article |
| id | doaj-art-7280c544a4144e09bb33da06caf5c20d |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-7280c544a4144e09bb33da06caf5c20d2025-08-20T02:58:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-05-011610.3389/fneur.2025.15607771560777Non-invasive therapeutics for neurotrauma: a mechanistic overviewJames D. O'LearyBevan S. MainMark P. BurnsTraumatic brain injury is a leading cause of death and a major risk factor for the development of both memory and motor disorders. To date, there are no proven interventions to improve patient outcome after neurotrauma. A promising avenue of treatment has emerged in the use of non-invasive therapies for recovery after brain injury. A number of non-invasive brain stimulation techniques have been developed, such as transcranial direct current stimulation, transcranial magnetic stimulation and vagus nerve stimulation, as well as low intensity ultrasound stimulation and photobiomodulation therapy. However, standardized treatment regimens have not been developed. There is a clear need to better understand the underlying mechanisms of non-invasive therapeutics on brain injury pathology so as to more effectively guide treatment strategy. Here we review the current literature of non-invasive therapies in preclinical neurotrauma and offer insight into the potential mechanism of action and novel targets for the treatment of traumatic brain injury.https://www.frontiersin.org/articles/10.3389/fneur.2025.1560777/fulltraumatic brain injuryplasticitynon-invasive brain stimulation (NIBS)blood brain barrier (BBB)inflammationtranscranial direct current electrical stimulation |
| spellingShingle | James D. O'Leary Bevan S. Main Mark P. Burns Non-invasive therapeutics for neurotrauma: a mechanistic overview Frontiers in Neurology traumatic brain injury plasticity non-invasive brain stimulation (NIBS) blood brain barrier (BBB) inflammation transcranial direct current electrical stimulation |
| title | Non-invasive therapeutics for neurotrauma: a mechanistic overview |
| title_full | Non-invasive therapeutics for neurotrauma: a mechanistic overview |
| title_fullStr | Non-invasive therapeutics for neurotrauma: a mechanistic overview |
| title_full_unstemmed | Non-invasive therapeutics for neurotrauma: a mechanistic overview |
| title_short | Non-invasive therapeutics for neurotrauma: a mechanistic overview |
| title_sort | non invasive therapeutics for neurotrauma a mechanistic overview |
| topic | traumatic brain injury plasticity non-invasive brain stimulation (NIBS) blood brain barrier (BBB) inflammation transcranial direct current electrical stimulation |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1560777/full |
| work_keys_str_mv | AT jamesdoleary noninvasivetherapeuticsforneurotraumaamechanisticoverview AT bevansmain noninvasivetherapeuticsforneurotraumaamechanisticoverview AT markpburns noninvasivetherapeuticsforneurotraumaamechanisticoverview |