Mitochondria in White, Brown, and Beige Adipocytes
Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6067349 |
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| author | Miroslava Cedikova Michaela Kripnerová Jana Dvorakova Pavel Pitule Martina Grundmanova Vaclav Babuska Dana Mullerova Jitka Kuncova |
| author_facet | Miroslava Cedikova Michaela Kripnerová Jana Dvorakova Pavel Pitule Martina Grundmanova Vaclav Babuska Dana Mullerova Jitka Kuncova |
| author_sort | Miroslava Cedikova |
| collection | DOAJ |
| description | Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown-like (bAT) adipose tissues. WAT is mainly involved in the storage and mobilization of energy and BAT is predominantly responsible for nonshivering thermogenesis. Recent data suggest that adipocyte mitochondria might play an important role in the development of obesity through defects in mitochondrial lipogenesis and lipolysis, regulation of adipocyte differentiation, apoptosis, production of oxygen radicals, efficiency of oxidative phosphorylation, and regulation of conversion of white adipocytes into brown-like adipocytes. This review summarizes the main characteristics of each adipose tissue subtype and describes morphological and functional modifications focusing on mitochondria and their activity in healthy and unhealthy adipocytes. |
| format | Article |
| id | doaj-art-7279a901db4f4454936a6173c50197ef |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-7279a901db4f4454936a6173c50197ef2025-02-03T01:02:39ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/60673496067349Mitochondria in White, Brown, and Beige AdipocytesMiroslava Cedikova0Michaela Kripnerová1Jana Dvorakova2Pavel Pitule3Martina Grundmanova4Vaclav Babuska5Dana Mullerova6Jitka Kuncova7Department of Physiology, Faculty of Medicine in Pilsen, Charles University in Prague, 301 00 Pilsen, Czech RepublicDepartment of Biology, Faculty of Medicine in Pilsen, Charles University in Prague, 301 00 Pilsen, Czech RepublicDepartment of Public Health and Preventive Medicine, Faculty of Medicine in Pilsen, Charles University in Prague, 301 00 Pilsen, Czech RepublicBiomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, 301 00 Pilsen, Czech RepublicDepartment of Physiology, Faculty of Medicine in Pilsen, Charles University in Prague, 301 00 Pilsen, Czech RepublicInstitute of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University in Prague, 301 00 Pilsen, Czech RepublicDepartment of Public Health and Preventive Medicine, Faculty of Medicine in Pilsen, Charles University in Prague, 301 00 Pilsen, Czech RepublicDepartment of Physiology, Faculty of Medicine in Pilsen, Charles University in Prague, 301 00 Pilsen, Czech RepublicMitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown-like (bAT) adipose tissues. WAT is mainly involved in the storage and mobilization of energy and BAT is predominantly responsible for nonshivering thermogenesis. Recent data suggest that adipocyte mitochondria might play an important role in the development of obesity through defects in mitochondrial lipogenesis and lipolysis, regulation of adipocyte differentiation, apoptosis, production of oxygen radicals, efficiency of oxidative phosphorylation, and regulation of conversion of white adipocytes into brown-like adipocytes. This review summarizes the main characteristics of each adipose tissue subtype and describes morphological and functional modifications focusing on mitochondria and their activity in healthy and unhealthy adipocytes.http://dx.doi.org/10.1155/2016/6067349 |
| spellingShingle | Miroslava Cedikova Michaela Kripnerová Jana Dvorakova Pavel Pitule Martina Grundmanova Vaclav Babuska Dana Mullerova Jitka Kuncova Mitochondria in White, Brown, and Beige Adipocytes Stem Cells International |
| title | Mitochondria in White, Brown, and Beige Adipocytes |
| title_full | Mitochondria in White, Brown, and Beige Adipocytes |
| title_fullStr | Mitochondria in White, Brown, and Beige Adipocytes |
| title_full_unstemmed | Mitochondria in White, Brown, and Beige Adipocytes |
| title_short | Mitochondria in White, Brown, and Beige Adipocytes |
| title_sort | mitochondria in white brown and beige adipocytes |
| url | http://dx.doi.org/10.1155/2016/6067349 |
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