Predictors of severe disease in Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study
Abstract Background Streptococcus dysgalactiae subsp. equisimilis (SDSE) is a leading cause of invasive β-hemolytic streptococcal infections in many countries and is increasingly recognized as a cause of severe disease. However, clinical data on severe SDSE disease remain limited. The aim of this st...
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2025-04-01
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| Online Access: | https://doi.org/10.1186/s12879-025-10966-8 |
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| author | Miia Saukkosaari Janne Aittoniemi Reetta Huttunen Tiina Luukkaala Sari Rantala |
| author_facet | Miia Saukkosaari Janne Aittoniemi Reetta Huttunen Tiina Luukkaala Sari Rantala |
| author_sort | Miia Saukkosaari |
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| description | Abstract Background Streptococcus dysgalactiae subsp. equisimilis (SDSE) is a leading cause of invasive β-hemolytic streptococcal infections in many countries and is increasingly recognized as a cause of severe disease. However, clinical data on severe SDSE disease remain limited. The aim of this study was to identify predictors of severe disease in SDSE bacteremia. Methods This retrospective study covered 217 episodes of SDSE bacteremia in 211 adult patients in the Pirkanmaa area, Finland from August 2015 to June 2018. Severe disease was defined as admission to an intensive care unit (ICU) and/or death. Results 10% of the patients had severe disease, and the overall 30-day case-fatality rate was 7.8%. Alcohol abuse (odds ratio [OR] 5.5 [95% confidence interval (CI) 1.1–28], p = 0.038) and malignancy (OR 4.2 [1.3–13], p = 0.014) were significantly associated with severe disease. Unconsciousness (OR 23 [1.9–271], p = 0.018), dyspnea (OR 5.4 [1.7–17], p = 0.005) or falling (OR 3.8 [1.1–13], p = 0.031) as the first sign or symptom predicted severe disease. Conclusion Alcohol abuse, malignancy, as well as unconsciousness, dyspnea and falling as first signs of infection were associated with severe disease in SDSE bacteremia. These novel findings expand our knowledge of SDSE bacteremia and provide valuable insights for identifying patients at the highest risk of severe disease. |
| format | Article |
| id | doaj-art-72759983147649c0974fe8ca059bedc8 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-72759983147649c0974fe8ca059bedc82025-08-20T03:37:19ZengBMCBMC Infectious Diseases1471-23342025-04-012511810.1186/s12879-025-10966-8Predictors of severe disease in Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based studyMiia Saukkosaari0Janne Aittoniemi1Reetta Huttunen2Tiina Luukkaala3Sari Rantala4Department of Internal Medicine, Tampere University HospitalFimlab LaboratoriesDepartment of Internal Medicine, Tampere University HospitalResearch, Development and Innovation Center, Tampere University HospitalDepartment of Internal Medicine, Tampere University HospitalAbstract Background Streptococcus dysgalactiae subsp. equisimilis (SDSE) is a leading cause of invasive β-hemolytic streptococcal infections in many countries and is increasingly recognized as a cause of severe disease. However, clinical data on severe SDSE disease remain limited. The aim of this study was to identify predictors of severe disease in SDSE bacteremia. Methods This retrospective study covered 217 episodes of SDSE bacteremia in 211 adult patients in the Pirkanmaa area, Finland from August 2015 to June 2018. Severe disease was defined as admission to an intensive care unit (ICU) and/or death. Results 10% of the patients had severe disease, and the overall 30-day case-fatality rate was 7.8%. Alcohol abuse (odds ratio [OR] 5.5 [95% confidence interval (CI) 1.1–28], p = 0.038) and malignancy (OR 4.2 [1.3–13], p = 0.014) were significantly associated with severe disease. Unconsciousness (OR 23 [1.9–271], p = 0.018), dyspnea (OR 5.4 [1.7–17], p = 0.005) or falling (OR 3.8 [1.1–13], p = 0.031) as the first sign or symptom predicted severe disease. Conclusion Alcohol abuse, malignancy, as well as unconsciousness, dyspnea and falling as first signs of infection were associated with severe disease in SDSE bacteremia. These novel findings expand our knowledge of SDSE bacteremia and provide valuable insights for identifying patients at the highest risk of severe disease.https://doi.org/10.1186/s12879-025-10966-8Streptococcus dysgalactiae subspecies equisimilisSDSEBacteremiaRisk factorMortalityDisease severity |
| spellingShingle | Miia Saukkosaari Janne Aittoniemi Reetta Huttunen Tiina Luukkaala Sari Rantala Predictors of severe disease in Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study BMC Infectious Diseases Streptococcus dysgalactiae subspecies equisimilis SDSE Bacteremia Risk factor Mortality Disease severity |
| title | Predictors of severe disease in Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study |
| title_full | Predictors of severe disease in Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study |
| title_fullStr | Predictors of severe disease in Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study |
| title_full_unstemmed | Predictors of severe disease in Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study |
| title_short | Predictors of severe disease in Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study |
| title_sort | predictors of severe disease in streptococcus dysgalactiae subsp equisimilis bacteremia a population based study |
| topic | Streptococcus dysgalactiae subspecies equisimilis SDSE Bacteremia Risk factor Mortality Disease severity |
| url | https://doi.org/10.1186/s12879-025-10966-8 |
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