The Role of CARD9 Deficiency in Neutrophils
Neutrophils play a critical role in innate immune defense and directly contribute to infectious and autoimmune ailments. Great efforts are underway to better understand the nature of neutrophilic inflammation. Of note, CARD9, a myeloid cell-specific signaling protein that mainly expresses in macroph...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/6643603 |
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| _version_ | 1832563224041488384 |
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| author | Ruanmei Sheng Xiaoming Zhong Zhiwen Yang Xuemin Wang |
| author_facet | Ruanmei Sheng Xiaoming Zhong Zhiwen Yang Xuemin Wang |
| author_sort | Ruanmei Sheng |
| collection | DOAJ |
| description | Neutrophils play a critical role in innate immune defense and directly contribute to infectious and autoimmune ailments. Great efforts are underway to better understand the nature of neutrophilic inflammation. Of note, CARD9, a myeloid cell-specific signaling protein that mainly expresses in macrophages and dendritic cells, is also present in neutrophils, emerging as a critical mediator for intercellular communication. CARD9–deficiency neutrophils display an increased susceptibility to fungal infection that primarily localize to the central nervous system, subcutaneous, and skin tissue. Additionally, CARD9–deficiency neutrophils are associated with some autoimmune diseases and even provide protection against a few bacteria. Here, the review summarizes recent preclinical and clinical advances that have provided a novel insight into the pathogenesis of CARD9 deficiency in neutrophils. |
| format | Article |
| id | doaj-art-7271a51b766e4159b73f8f40e7ba715d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7271a51b766e4159b73f8f40e7ba715d2025-02-03T01:20:43ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/66436036643603The Role of CARD9 Deficiency in NeutrophilsRuanmei Sheng0Xiaoming Zhong1Zhiwen Yang2Xuemin Wang3Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai, ChinaJiangxi Province Tumor Hospital, Nanchang, ChinaSongjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai, ChinaSongjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai, ChinaNeutrophils play a critical role in innate immune defense and directly contribute to infectious and autoimmune ailments. Great efforts are underway to better understand the nature of neutrophilic inflammation. Of note, CARD9, a myeloid cell-specific signaling protein that mainly expresses in macrophages and dendritic cells, is also present in neutrophils, emerging as a critical mediator for intercellular communication. CARD9–deficiency neutrophils display an increased susceptibility to fungal infection that primarily localize to the central nervous system, subcutaneous, and skin tissue. Additionally, CARD9–deficiency neutrophils are associated with some autoimmune diseases and even provide protection against a few bacteria. Here, the review summarizes recent preclinical and clinical advances that have provided a novel insight into the pathogenesis of CARD9 deficiency in neutrophils.http://dx.doi.org/10.1155/2021/6643603 |
| spellingShingle | Ruanmei Sheng Xiaoming Zhong Zhiwen Yang Xuemin Wang The Role of CARD9 Deficiency in Neutrophils Mediators of Inflammation |
| title | The Role of CARD9 Deficiency in Neutrophils |
| title_full | The Role of CARD9 Deficiency in Neutrophils |
| title_fullStr | The Role of CARD9 Deficiency in Neutrophils |
| title_full_unstemmed | The Role of CARD9 Deficiency in Neutrophils |
| title_short | The Role of CARD9 Deficiency in Neutrophils |
| title_sort | role of card9 deficiency in neutrophils |
| url | http://dx.doi.org/10.1155/2021/6643603 |
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