The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.

The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.

Genome-wide association studies (GWAS) have revealed 74 single nucleotide polymorphisms (SNPs) associated with high-density lipoprotein cholesterol (HDL) blood levels. This study is, to our knowledge, the first genome-wide interaction study (GWIS) to identify SNP×SNP interactions associated with HDL...

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Main Authors: Elisabeth M van Leeuwen, Françoise A S Smouter, Tony Kam-Thong, Nazanin Karbalai, Albert V Smith, Tamara B Harris, Lenore J Launer, Colleen M Sitlani, Guo Li, Jennifer A Brody, Joshua C Bis, Charles C White, Alok Jaiswal, Ben A Oostra, Albert Hofman, Fernando Rivadeneira, Andre G Uitterlinden, Eric Boerwinkle, Christie M Ballantyne, Vilmundur Gudnason, Bruce M Psaty, L Adrienne Cupples, Marjo-Riitta Järvelin, Samuli Ripatti, Aaron Isaacs, Bertram Müller-Myhsok, Lennart C Karssen, Cornelia M van Duijn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0109290
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