A short overview of Clostridium perfringens: Relevancy, Toxinotypes, Clinical Impacts, and the Challenges of Biofilm Formation
C.perfringens, a ubiquitous bacterium, is implicated in a series of recent outbreaks across Europe, reflecting its significance in public health. The organism manifests different clinical presentations in both human and animal hosts. In the realm of veterinary science, its pathogenesis in species su...
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| Format: | Article |
| Language: | English |
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Agroprint Timisoara
2024-05-01
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| Series: | Scientific Papers Animal Science and Biotechnologies |
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| Online Access: | https://spasb.ro/index.php/public_html/article/view/2227 |
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| author | Mara-Georgiana Haralambie Alina Țărnă Aurelia Coroian Ana-Maria-Cristina Imbrea Igori Balta Lavinia Ștef Nicolae Corcionivoschi |
| author_facet | Mara-Georgiana Haralambie Alina Țărnă Aurelia Coroian Ana-Maria-Cristina Imbrea Igori Balta Lavinia Ștef Nicolae Corcionivoschi |
| author_sort | Mara-Georgiana Haralambie |
| collection | DOAJ |
| description | C.perfringens, a ubiquitous bacterium, is implicated in a series of recent outbreaks across Europe, reflecting its significance in public health. The organism manifests different clinical presentations in both human and animal hosts. In the realm of veterinary science, its pathogenesis in species such as poultry, cattle, swine, and equines is of particular concern due to the economic implications stemming from morbidity and mortality rates. The enterotoxins produced by this bacterium is the primary cause of symptoms like watery diarrhea, abdominal pains, and cramps in humans, and leads to conditions such as clostridial myonecrosis and necrotic enteritis in animals. An important aspect of its virulence strategy is its ability to form biofilms. These sophisticated microbial assemblages confer an augmented resistance against environmental challenges and antimicrobial interventions. This review consolidates information about C. perfringens outbreaks in Europe, mode of infection, pathogenesis in various animals, associated clinical symptoms, and the nuances of its biofilm formation. The present literature synthesis could provide valuable insights for forthcoming preventive and therapeutic initiatives. |
| format | Article |
| id | doaj-art-726c1ed71a304e4f8e6175e6bcdcc98f |
| institution | OA Journals |
| issn | 1841-9364 2344-4576 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Agroprint Timisoara |
| record_format | Article |
| series | Scientific Papers Animal Science and Biotechnologies |
| spelling | doaj-art-726c1ed71a304e4f8e6175e6bcdcc98f2025-08-20T02:26:10ZengAgroprint TimisoaraScientific Papers Animal Science and Biotechnologies1841-93642344-45762024-05-0157170702227A short overview of Clostridium perfringens: Relevancy, Toxinotypes, Clinical Impacts, and the Challenges of Biofilm FormationMara-Georgiana Haralambie0Alina Țărnă1Aurelia Coroian2Ana-Maria-Cristina Imbrea3Igori Balta4Lavinia Ștef5Nicolae Corcionivoschi6University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania University of Life Sciences King Mihai I from Timisoara, 300645 Timisoara, RomaniaUniversity of Life Sciences King Mihai I from Timisoara, 300645 Timisoara, RomaniaUniversity of Life Sciences King Mihai I from Timisoara, 300645 Timisoara, RomaniaBacteriology Branch, Veterinary Sciences Division, Agri-Food and Biosciences Institute, Belfast BT4 3SD, UKC.perfringens, a ubiquitous bacterium, is implicated in a series of recent outbreaks across Europe, reflecting its significance in public health. The organism manifests different clinical presentations in both human and animal hosts. In the realm of veterinary science, its pathogenesis in species such as poultry, cattle, swine, and equines is of particular concern due to the economic implications stemming from morbidity and mortality rates. The enterotoxins produced by this bacterium is the primary cause of symptoms like watery diarrhea, abdominal pains, and cramps in humans, and leads to conditions such as clostridial myonecrosis and necrotic enteritis in animals. An important aspect of its virulence strategy is its ability to form biofilms. These sophisticated microbial assemblages confer an augmented resistance against environmental challenges and antimicrobial interventions. This review consolidates information about C. perfringens outbreaks in Europe, mode of infection, pathogenesis in various animals, associated clinical symptoms, and the nuances of its biofilm formation. The present literature synthesis could provide valuable insights for forthcoming preventive and therapeutic initiatives.https://spasb.ro/index.php/public_html/article/view/2227clostridium perfringensinfection and pathogenesistoxinotypesclinical manifestationsbiofilm formation |
| spellingShingle | Mara-Georgiana Haralambie Alina Țărnă Aurelia Coroian Ana-Maria-Cristina Imbrea Igori Balta Lavinia Ștef Nicolae Corcionivoschi A short overview of Clostridium perfringens: Relevancy, Toxinotypes, Clinical Impacts, and the Challenges of Biofilm Formation Scientific Papers Animal Science and Biotechnologies clostridium perfringens infection and pathogenesis toxinotypes clinical manifestations biofilm formation |
| title | A short overview of Clostridium perfringens: Relevancy, Toxinotypes, Clinical Impacts, and the Challenges of Biofilm Formation |
| title_full | A short overview of Clostridium perfringens: Relevancy, Toxinotypes, Clinical Impacts, and the Challenges of Biofilm Formation |
| title_fullStr | A short overview of Clostridium perfringens: Relevancy, Toxinotypes, Clinical Impacts, and the Challenges of Biofilm Formation |
| title_full_unstemmed | A short overview of Clostridium perfringens: Relevancy, Toxinotypes, Clinical Impacts, and the Challenges of Biofilm Formation |
| title_short | A short overview of Clostridium perfringens: Relevancy, Toxinotypes, Clinical Impacts, and the Challenges of Biofilm Formation |
| title_sort | short overview of clostridium perfringens relevancy toxinotypes clinical impacts and the challenges of biofilm formation |
| topic | clostridium perfringens infection and pathogenesis toxinotypes clinical manifestations biofilm formation |
| url | https://spasb.ro/index.php/public_html/article/view/2227 |
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