Dengue in the campus community of an overseas American university: A cross-sectional study
Introduction: After a large outbreak of dengue virus (DENV) serotype-3 in Saint Kitts and Nevis (SKN) in 2008, we performed a cross-sectional study to determine the prevalence of anti-DENV immunoglobulin G (IgG) antibodies in expatriate and local persons affiliated with an American veterinary schoo...
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The Journal of Infection in Developing Countries
2019-03-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/10701 |
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| author | Hamish Mohammed Mary H Hayden Elise Lee Luis M Santiago Rosina C Krecek Floyd Revan Elizabeth Hunsperger |
| author_facet | Hamish Mohammed Mary H Hayden Elise Lee Luis M Santiago Rosina C Krecek Floyd Revan Elizabeth Hunsperger |
| author_sort | Hamish Mohammed |
| collection | DOAJ |
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Introduction: After a large outbreak of dengue virus (DENV) serotype-3 in Saint Kitts and Nevis (SKN) in 2008, we performed a cross-sectional study to determine the prevalence of anti-DENV immunoglobulin G (IgG) antibodies in expatriate and local persons affiliated with an American veterinary school there.
Methodology: This campus community comprised mostly expatriate students and faculty and Kittitian administrative staff. In 2009, a stratified random sample of students, faculty and staff was invited to complete an electronic survey to assess risk factors for DENV and provide blood for testing for anti-DENV IgG antibodies by an enzyme-linked immunosorbent assay. IgG-positive specimens were also tested by a 90% plaque reduction neutralization test (PRNT90) to determine immunoreactivity to DENV (1-4) serotypes and West Nile virus. Risk factors for anti-DENV IgG seropositivity were determined using simple and adjusted logistic regression.
Results: Of the 118 participants, the overall prevalence of DENV IgG antibodies was 44.1% (95% confidence interval [CI]: 35.1-53.0%), ranging from 30.1% in students, 100.0% in staff and 57.9% in faculty (p < 0.001). Duration of residence in St. Kitts was the only variable significantly associated with seropositivity on multiple logistic regression (adjusted odds ratio [95% CI]: 1.21 [1.07-1.37]). The serotype of DENV was determined in 11 persons: DENV-1 (n = 4), DENV-2 (n = 3), and DENV-3 (n = 4).
Conclusions: Expatriate students and faculty moving to St. Kitts from non-endemic areas were at high risk of DENV infection. There is a need for increased emphasis on pre-travel mosquito-borne virus prevention education for persons moving to St. Kitts to study and work.
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| format | Article |
| id | doaj-art-726b2fec2fd545ccb4e091e969202965 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-726b2fec2fd545ccb4e091e9692029652025-08-20T02:16:18ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802019-03-01130310.3855/jidc.10701Dengue in the campus community of an overseas American university: A cross-sectional studyHamish Mohammed0Mary H Hayden1Elise Lee2Luis M Santiago3Rosina C Krecek4Floyd Revan5Elizabeth Hunsperger6Ross University School of Veterinary Medicine, West Farm, Saint Kitts and NevisNational Center for Atmospheric Research, Boulder, CO, United StatesRoss University School of Veterinary Medicine, West Farm, Saint Kitts and NevisDengue Branch, U.S. Centers for Disease Control and Prevention, San Juan, Puerto RicoRoss University School of Veterinary Medicine, West Farm, Saint Kitts and NevisRoss University School of Veterinary Medicine, West Farm, Saint Kitts and NevisDengue Branch, U.S. Centers for Disease Control and Prevention, San Juan, Puerto Rico Introduction: After a large outbreak of dengue virus (DENV) serotype-3 in Saint Kitts and Nevis (SKN) in 2008, we performed a cross-sectional study to determine the prevalence of anti-DENV immunoglobulin G (IgG) antibodies in expatriate and local persons affiliated with an American veterinary school there. Methodology: This campus community comprised mostly expatriate students and faculty and Kittitian administrative staff. In 2009, a stratified random sample of students, faculty and staff was invited to complete an electronic survey to assess risk factors for DENV and provide blood for testing for anti-DENV IgG antibodies by an enzyme-linked immunosorbent assay. IgG-positive specimens were also tested by a 90% plaque reduction neutralization test (PRNT90) to determine immunoreactivity to DENV (1-4) serotypes and West Nile virus. Risk factors for anti-DENV IgG seropositivity were determined using simple and adjusted logistic regression. Results: Of the 118 participants, the overall prevalence of DENV IgG antibodies was 44.1% (95% confidence interval [CI]: 35.1-53.0%), ranging from 30.1% in students, 100.0% in staff and 57.9% in faculty (p < 0.001). Duration of residence in St. Kitts was the only variable significantly associated with seropositivity on multiple logistic regression (adjusted odds ratio [95% CI]: 1.21 [1.07-1.37]). The serotype of DENV was determined in 11 persons: DENV-1 (n = 4), DENV-2 (n = 3), and DENV-3 (n = 4). Conclusions: Expatriate students and faculty moving to St. Kitts from non-endemic areas were at high risk of DENV infection. There is a need for increased emphasis on pre-travel mosquito-borne virus prevention education for persons moving to St. Kitts to study and work. https://jidc.org/index.php/journal/article/view/10701dengue feverSaint Kitts and NevisTravellers |
| spellingShingle | Hamish Mohammed Mary H Hayden Elise Lee Luis M Santiago Rosina C Krecek Floyd Revan Elizabeth Hunsperger Dengue in the campus community of an overseas American university: A cross-sectional study Journal of Infection in Developing Countries dengue fever Saint Kitts and Nevis Travellers |
| title | Dengue in the campus community of an overseas American university: A cross-sectional study |
| title_full | Dengue in the campus community of an overseas American university: A cross-sectional study |
| title_fullStr | Dengue in the campus community of an overseas American university: A cross-sectional study |
| title_full_unstemmed | Dengue in the campus community of an overseas American university: A cross-sectional study |
| title_short | Dengue in the campus community of an overseas American university: A cross-sectional study |
| title_sort | dengue in the campus community of an overseas american university a cross sectional study |
| topic | dengue fever Saint Kitts and Nevis Travellers |
| url | https://jidc.org/index.php/journal/article/view/10701 |
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