Identification and experimental validation of ulcerative colitis-associated hub genes through integrated WGCNA and lysosomal autophagy analysis

Identification and experimental validation of ulcerative colitis-associated hub genes through integrated WGCNA and lysosomal autophagy analysis

Abstract Objective This study aims to systematically identify differentially expressed genes associated with lysosomal autophagy in ulcerative colitis (UC) and validate key candidate genes in an animal model, thereby providing novel insights driving UC pathogenesis. Methods The GSE47908 dataset from...

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Bibliographic Details
Main Authors: Yuanpei Zhao, Yijun Li, Qingwen Xu, Lili Ding, Weiming Li, Qinghua Zou, Yichen Hu, Kaiwen Shi, Hongyuan Liu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Human Genomics
Subjects:
Ulcerative colitis
WGCNA
Lysosomal autophagy
Immune infiltration
Bioinformatics analysis
Online Access:https://doi.org/10.1186/s40246-025-00783-0
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