Polymorphisms of <i>TXK</i> and <i>PLCE1</i> Genes and Their Correlation Analysis with Growth Traits in Ashidan Yaks
The tyrosine protein kinase (<i>TXK</i>) gene, as a member of the non-receptor tyrosine kinase Tec family, plays a vital role in signal transduction mediation. Phospholipase C epsilon 1 (<i>PLCE1</i>), a membrane-associated enzyme, is of paramount importance for the different...
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2024-12-01
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| author | Juanxiang Zhang Xita Zha Guowu Yang Xiaoming Ma Yongfu La Xiaoyun Wu Xian Guo Min Chu Pengjia Bao Ping Yan Chunnian Liang |
| author_facet | Juanxiang Zhang Xita Zha Guowu Yang Xiaoming Ma Yongfu La Xiaoyun Wu Xian Guo Min Chu Pengjia Bao Ping Yan Chunnian Liang |
| author_sort | Juanxiang Zhang |
| collection | DOAJ |
| description | The tyrosine protein kinase (<i>TXK</i>) gene, as a member of the non-receptor tyrosine kinase Tec family, plays a vital role in signal transduction mediation. Phospholipase C epsilon 1 (<i>PLCE1</i>), a membrane-associated enzyme, is of paramount importance for the differentiation of myoblasts and the normal functioning of muscle tissue. In recent years, both of these genes have been reported to be associated with the economic traits of animals. This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) in the <i>TXK</i> and <i>PLCE1</i> genes and growth traits in Ashidan yaks and to search for potential molecular marker loci that can influence Ashidan yak breeding. A cGPS liquid microarray was utilized to genotype 232 Ashidan yaks and to analyze correlations between two SNP loci in the <i>TXK</i> and <i>PLCE1</i> genes and yak body weight, body height, body length, and chest circumference at different periods. The results indicated that the g.55,999,531C>T locus of the <i>TXK</i> gene and the g.342,350T>G locus of the <i>PLCE1</i> gene were significantly correlated with the growth traits of Ashidan yaks. Among these, individuals with the CC genotype at the g.55,999,531C>T locus showed a significantly higher body length at 6 months old compared to TT individuals, and those with the CT genotype at 12 months old had a significantly higher chest circumference than TT individuals. At the g.342,350T>G locus, the body height of GG genotype individuals at 18 months of age was significantly higher than that of TT genotype individuals and TG genotype individuals. The above findings can be used as theoretical support for the subsequent improvement of Ashidan yak breeding. |
| format | Article |
| id | doaj-art-72687eb849fd4129bc7ffc10f289371b |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-72687eb849fd4129bc7ffc10f289371b2024-12-13T16:21:29ZengMDPI AGAnimals2076-26152024-12-011423350610.3390/ani14233506Polymorphisms of <i>TXK</i> and <i>PLCE1</i> Genes and Their Correlation Analysis with Growth Traits in Ashidan YaksJuanxiang Zhang0Xita Zha1Guowu Yang2Xiaoming Ma3Yongfu La4Xiaoyun Wu5Xian Guo6Min Chu7Pengjia Bao8Ping Yan9Chunnian Liang10Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, ChinaQinghai Qilian County Animal Husbandry and Veterinary Workstation, Qilian 810400, ChinaLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, ChinaLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, ChinaLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, ChinaLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, ChinaLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, ChinaLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, ChinaLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, ChinaLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, ChinaLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, ChinaThe tyrosine protein kinase (<i>TXK</i>) gene, as a member of the non-receptor tyrosine kinase Tec family, plays a vital role in signal transduction mediation. Phospholipase C epsilon 1 (<i>PLCE1</i>), a membrane-associated enzyme, is of paramount importance for the differentiation of myoblasts and the normal functioning of muscle tissue. In recent years, both of these genes have been reported to be associated with the economic traits of animals. This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) in the <i>TXK</i> and <i>PLCE1</i> genes and growth traits in Ashidan yaks and to search for potential molecular marker loci that can influence Ashidan yak breeding. A cGPS liquid microarray was utilized to genotype 232 Ashidan yaks and to analyze correlations between two SNP loci in the <i>TXK</i> and <i>PLCE1</i> genes and yak body weight, body height, body length, and chest circumference at different periods. The results indicated that the g.55,999,531C>T locus of the <i>TXK</i> gene and the g.342,350T>G locus of the <i>PLCE1</i> gene were significantly correlated with the growth traits of Ashidan yaks. Among these, individuals with the CC genotype at the g.55,999,531C>T locus showed a significantly higher body length at 6 months old compared to TT individuals, and those with the CT genotype at 12 months old had a significantly higher chest circumference than TT individuals. At the g.342,350T>G locus, the body height of GG genotype individuals at 18 months of age was significantly higher than that of TT genotype individuals and TG genotype individuals. The above findings can be used as theoretical support for the subsequent improvement of Ashidan yak breeding.https://www.mdpi.com/2076-2615/14/23/3506<i>TXK</i> gene<i>PLCE1</i> genegrowth traitscorrelation analysisAshidan yak |
| spellingShingle | Juanxiang Zhang Xita Zha Guowu Yang Xiaoming Ma Yongfu La Xiaoyun Wu Xian Guo Min Chu Pengjia Bao Ping Yan Chunnian Liang Polymorphisms of <i>TXK</i> and <i>PLCE1</i> Genes and Their Correlation Analysis with Growth Traits in Ashidan Yaks Animals <i>TXK</i> gene <i>PLCE1</i> gene growth traits correlation analysis Ashidan yak |
| title | Polymorphisms of <i>TXK</i> and <i>PLCE1</i> Genes and Their Correlation Analysis with Growth Traits in Ashidan Yaks |
| title_full | Polymorphisms of <i>TXK</i> and <i>PLCE1</i> Genes and Their Correlation Analysis with Growth Traits in Ashidan Yaks |
| title_fullStr | Polymorphisms of <i>TXK</i> and <i>PLCE1</i> Genes and Their Correlation Analysis with Growth Traits in Ashidan Yaks |
| title_full_unstemmed | Polymorphisms of <i>TXK</i> and <i>PLCE1</i> Genes and Their Correlation Analysis with Growth Traits in Ashidan Yaks |
| title_short | Polymorphisms of <i>TXK</i> and <i>PLCE1</i> Genes and Their Correlation Analysis with Growth Traits in Ashidan Yaks |
| title_sort | polymorphisms of i txk i and i plce1 i genes and their correlation analysis with growth traits in ashidan yaks |
| topic | <i>TXK</i> gene <i>PLCE1</i> gene growth traits correlation analysis Ashidan yak |
| url | https://www.mdpi.com/2076-2615/14/23/3506 |
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