miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery
Ischemic stroke is a leading cause of mortality and long-term disability globally. One of its aspects is the breakdown of the blood-brain barrier (BBB). The disruption of BBB’s integrity during stroke exacerbates neurological damage and hampers therapeutic intervention. Recent advances in regenerati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2025.1503193/full |
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| author | Vojtech Sprincl Vojtech Sprincl Nataliya Romanyuk |
| author_facet | Vojtech Sprincl Vojtech Sprincl Nataliya Romanyuk |
| author_sort | Vojtech Sprincl |
| collection | DOAJ |
| description | Ischemic stroke is a leading cause of mortality and long-term disability globally. One of its aspects is the breakdown of the blood-brain barrier (BBB). The disruption of BBB’s integrity during stroke exacerbates neurological damage and hampers therapeutic intervention. Recent advances in regenerative medicine suggest that mesenchymal stem cells (MSCs) derived extracellular vesicles (EVs) show promise for restoring BBB integrity. This review explores the potential of MSC-derived EVs in mediating neuroprotective and reparative effects on the BBB after ischemic stroke. We highlight the molecular cargo of MSC-derived EVs, including miRNAs, and their role in enhancing angiogenesis, promoting the BBB and neural repair, and mitigating apoptosis. Furthermore, we discuss the challenges associated with the clinical translation of MSC-derived EV therapies and the possibilities of further enhancing EVs’ innate protective qualities. Our findings underscore the need for further research to optimize the therapeutic potential of EVs and establish their efficacy and safety in clinical settings. |
| format | Article |
| id | doaj-art-7261ca794e914e07af47bc29edd61b2e |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-7261ca794e914e07af47bc29edd61b2e2025-02-07T06:49:38ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-02-011910.3389/fncel.2025.15031931503193miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recoveryVojtech Sprincl0Vojtech Sprincl1Nataliya Romanyuk2Department of Neuroregeneration, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, CzechiaDepartment of Neuroscience, 2nd Medical Faculty, Charles University, Prague, CzechiaDepartment of Neuroregeneration, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, CzechiaIschemic stroke is a leading cause of mortality and long-term disability globally. One of its aspects is the breakdown of the blood-brain barrier (BBB). The disruption of BBB’s integrity during stroke exacerbates neurological damage and hampers therapeutic intervention. Recent advances in regenerative medicine suggest that mesenchymal stem cells (MSCs) derived extracellular vesicles (EVs) show promise for restoring BBB integrity. This review explores the potential of MSC-derived EVs in mediating neuroprotective and reparative effects on the BBB after ischemic stroke. We highlight the molecular cargo of MSC-derived EVs, including miRNAs, and their role in enhancing angiogenesis, promoting the BBB and neural repair, and mitigating apoptosis. Furthermore, we discuss the challenges associated with the clinical translation of MSC-derived EV therapies and the possibilities of further enhancing EVs’ innate protective qualities. Our findings underscore the need for further research to optimize the therapeutic potential of EVs and establish their efficacy and safety in clinical settings.https://www.frontiersin.org/articles/10.3389/fncel.2025.1503193/fullacute ischemic strokemesenchymal stem cellextracellular vesicleexosomemiRNAblood-brain barrier |
| spellingShingle | Vojtech Sprincl Vojtech Sprincl Nataliya Romanyuk miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery Frontiers in Cellular Neuroscience acute ischemic stroke mesenchymal stem cell extracellular vesicle exosome miRNA blood-brain barrier |
| title | miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery |
| title_full | miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery |
| title_fullStr | miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery |
| title_full_unstemmed | miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery |
| title_short | miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery |
| title_sort | mirna in blood brain barrier repair role of extracellular vesicles in stroke recovery |
| topic | acute ischemic stroke mesenchymal stem cell extracellular vesicle exosome miRNA blood-brain barrier |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2025.1503193/full |
| work_keys_str_mv | AT vojtechsprincl mirnainbloodbrainbarrierrepairroleofextracellularvesiclesinstrokerecovery AT vojtechsprincl mirnainbloodbrainbarrierrepairroleofextracellularvesiclesinstrokerecovery AT nataliyaromanyuk mirnainbloodbrainbarrierrepairroleofextracellularvesiclesinstrokerecovery |