A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue
The in silico analyses of 109 replication-competent genomic DNA sequences isolated from cow milk and its products (97 in the bovine meat and milk factors 2 group – BMMF2, and additional 4 in BMMF1) seems to place these in a specific class of infectious agents spanning between bacterial plasmid and c...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1651620 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849702735465676800 |
|---|---|
| author | Ethel-Michele de Villiers Karin Gunst Deblina Chakraborty Claudia Ernst Timo Bund Harald zur Hausen |
| author_facet | Ethel-Michele de Villiers Karin Gunst Deblina Chakraborty Claudia Ernst Timo Bund Harald zur Hausen |
| author_sort | Ethel-Michele de Villiers |
| collection | DOAJ |
| description | The in silico analyses of 109 replication-competent genomic DNA sequences isolated from cow milk and its products (97 in the bovine meat and milk factors 2 group – BMMF2, and additional 4 in BMMF1) seems to place these in a specific class of infectious agents spanning between bacterial plasmid and circular ssDNA viruses. Satellite-type small plasmids with partial homology to larger genomes, were also isolated in both groups. A member of the BMMF1 group H1MBS.1 was recovered in a distinctly modified form from colon tissue by laser microdissection. Although the evolutionary origin is unknown, it draws the attention to the existence of a hitherto unrecognized, broad spectrum of potential pathogens. Indirect hints to the origin and structure of our isolates, as well as to their replicative behaviour, result from parallels drawn to the Hepatitis deltavirus genome structure and replication. |
| format | Article |
| id | doaj-art-725f2a0905214357be7cd71ec0718fb3 |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-725f2a0905214357be7cd71ec0718fb32025-08-20T03:17:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811205121810.1080/22221751.2019.1651620A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissueEthel-Michele de Villiers0Karin Gunst1Deblina Chakraborty2Claudia Ernst3Timo Bund4Harald zur Hausen5Episomal-Persistent DNA in Cancer- and Chronic Diseases, Deutsches Krebsforschungszentrum, Heidelberg, GermanyEpisomal-Persistent DNA in Cancer- and Chronic Diseases, Deutsches Krebsforschungszentrum, Heidelberg, GermanyEpisomal-Persistent DNA in Cancer- and Chronic Diseases, Deutsches Krebsforschungszentrum, Heidelberg, GermanyEpisomal-Persistent DNA in Cancer- and Chronic Diseases, Deutsches Krebsforschungszentrum, Heidelberg, GermanyEpisomal-Persistent DNA in Cancer- and Chronic Diseases, Deutsches Krebsforschungszentrum, Heidelberg, GermanyEpisomal-Persistent DNA in Cancer- and Chronic Diseases, Deutsches Krebsforschungszentrum, Heidelberg, GermanyThe in silico analyses of 109 replication-competent genomic DNA sequences isolated from cow milk and its products (97 in the bovine meat and milk factors 2 group – BMMF2, and additional 4 in BMMF1) seems to place these in a specific class of infectious agents spanning between bacterial plasmid and circular ssDNA viruses. Satellite-type small plasmids with partial homology to larger genomes, were also isolated in both groups. A member of the BMMF1 group H1MBS.1 was recovered in a distinctly modified form from colon tissue by laser microdissection. Although the evolutionary origin is unknown, it draws the attention to the existence of a hitherto unrecognized, broad spectrum of potential pathogens. Indirect hints to the origin and structure of our isolates, as well as to their replicative behaviour, result from parallels drawn to the Hepatitis deltavirus genome structure and replication.https://www.tandfonline.com/doi/10.1080/22221751.2019.1651620Infectious bovine meat milk factorsnew classplasmid DNAcolon tissuepathogenesis |
| spellingShingle | Ethel-Michele de Villiers Karin Gunst Deblina Chakraborty Claudia Ernst Timo Bund Harald zur Hausen A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue Emerging Microbes and Infections Infectious bovine meat milk factors new class plasmid DNA colon tissue pathogenesis |
| title | A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue |
| title_full | A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue |
| title_fullStr | A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue |
| title_full_unstemmed | A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue |
| title_short | A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue |
| title_sort | specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue |
| topic | Infectious bovine meat milk factors new class plasmid DNA colon tissue pathogenesis |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1651620 |
| work_keys_str_mv | AT ethelmicheledevilliers aspecificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT karingunst aspecificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT deblinachakraborty aspecificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT claudiaernst aspecificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT timobund aspecificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT haraldzurhausen aspecificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT ethelmicheledevilliers specificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT karingunst specificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT deblinachakraborty specificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT claudiaernst specificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT timobund specificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue AT haraldzurhausen specificclassofinfectiousagentsisolatedfrombovineserumanddairyproductsandperitumoralcoloncancertissue |