The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020
Background: Previous studies provided contradictory evidence regarding the relationship between metal concentrations and ischemic stroke (IS). Methods: A total of 100 adults with IS were included in this study, as well as an equal number of controls. Inductively coupled plasma-mass was used to measu...
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Elsevier
2025-04-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132500421X |
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| author | Yuese Yuan Li Zhang Fuying Liu Haobo Liu Ying Wang Xiujuan Yang Liangpo Liu Ben Li Li Wang Jin Yang Hongyan Cao Yulan Qiu Jinping Zheng Jian Guo Yi Gao |
| author_facet | Yuese Yuan Li Zhang Fuying Liu Haobo Liu Ying Wang Xiujuan Yang Liangpo Liu Ben Li Li Wang Jin Yang Hongyan Cao Yulan Qiu Jinping Zheng Jian Guo Yi Gao |
| author_sort | Yuese Yuan |
| collection | DOAJ |
| description | Background: Previous studies provided contradictory evidence regarding the relationship between metal concentrations and ischemic stroke (IS). Methods: A total of 100 adults with IS were included in this study, as well as an equal number of controls. Inductively coupled plasma-mass was used to measure metals’ concentrations in whole blood and plasma. In order to identify metals that were associated with IS, we applied principal component analysis (PCA) and principal component (PC) regression. Finally, we included 3867 participants from the US National Health and Nutrition Examination Survey (NHANES) 2011–2020 to estimate the association between urine tin (Sn) and stroke with logistic regression and COX proportional hazard models. Results: The fourth PC, characterized by copper (Cu) and Sn in whole blood, was associated with a higher risk of IS (OR=19.43, 95 %CI: 4.25, 88.89 for the highest quartile vs. the lowest quartile). A higher risk of IS was linked to the second PC, characterized by Sn, aluminum (Al), titanium (Ti), nickel (Ni) in plasma (OR= 12.85, 95 %CI: 3.91, 42.26 for the highest quartile vs. the lowest quartile). For NHANES, Sn was associated with a higher risk of stroke (OR= 1.69, 95 %CI: 1.07, 2.66 for the highest quartile vs. the lowest quartile). There was no significant relationship between urine Sn and all-cause deaths. Conclusion: In this research, the exposures of Sn, Cu, Al, Ti, and Ni were associated with IS. Specifically, the relationship between Sn and the risk of stroke has been established among both Chinese and US participants. |
| format | Article |
| id | doaj-art-725d4b68bd254c09b27e80c616cd6da2 |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-725d4b68bd254c09b27e80c616cd6da22025-08-20T03:17:35ZengElsevierEcotoxicology and Environmental Safety0147-65132025-04-0129411808510.1016/j.ecoenv.2025.118085The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020Yuese Yuan0Li Zhang1Fuying Liu2Haobo Liu3Ying Wang4Xiujuan Yang5Liangpo Liu6Ben Li7Li Wang8Jin Yang9Hongyan Cao10Yulan Qiu11Jinping Zheng12Jian Guo13Yi Gao14School of Public Health, Shanxi Medical University, Taiyuan 030001, China; State Key Laboratory for Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Medical Administration, Shanxi Provincial People's Hospital, Taiyuan 030012, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaDepartment of Neurosurgery, General Hospital of Yangquan Coal Industry Group, Yangquan 045000, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaState Key Laboratory for Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Beijing 100730, China; Corresponding author.School of Public Health, Shanxi Medical University, Taiyuan 030001, China; State Key Laboratory for Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Beijing 100730, China; Correspondence to: State Key Laboratory for Complex, Severe, and Rare Disease, Peking Union Medical College Hospital, Beijing, 100730, China.Background: Previous studies provided contradictory evidence regarding the relationship between metal concentrations and ischemic stroke (IS). Methods: A total of 100 adults with IS were included in this study, as well as an equal number of controls. Inductively coupled plasma-mass was used to measure metals’ concentrations in whole blood and plasma. In order to identify metals that were associated with IS, we applied principal component analysis (PCA) and principal component (PC) regression. Finally, we included 3867 participants from the US National Health and Nutrition Examination Survey (NHANES) 2011–2020 to estimate the association between urine tin (Sn) and stroke with logistic regression and COX proportional hazard models. Results: The fourth PC, characterized by copper (Cu) and Sn in whole blood, was associated with a higher risk of IS (OR=19.43, 95 %CI: 4.25, 88.89 for the highest quartile vs. the lowest quartile). A higher risk of IS was linked to the second PC, characterized by Sn, aluminum (Al), titanium (Ti), nickel (Ni) in plasma (OR= 12.85, 95 %CI: 3.91, 42.26 for the highest quartile vs. the lowest quartile). For NHANES, Sn was associated with a higher risk of stroke (OR= 1.69, 95 %CI: 1.07, 2.66 for the highest quartile vs. the lowest quartile). There was no significant relationship between urine Sn and all-cause deaths. Conclusion: In this research, the exposures of Sn, Cu, Al, Ti, and Ni were associated with IS. Specifically, the relationship between Sn and the risk of stroke has been established among both Chinese and US participants.http://www.sciencedirect.com/science/article/pii/S014765132500421XHeavy metalsStrokeChinaNHANES |
| spellingShingle | Yuese Yuan Li Zhang Fuying Liu Haobo Liu Ying Wang Xiujuan Yang Liangpo Liu Ben Li Li Wang Jin Yang Hongyan Cao Yulan Qiu Jinping Zheng Jian Guo Yi Gao The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020 Ecotoxicology and Environmental Safety Heavy metals Stroke China NHANES |
| title | The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020 |
| title_full | The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020 |
| title_fullStr | The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020 |
| title_full_unstemmed | The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020 |
| title_short | The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020 |
| title_sort | association of heavy metals metalloid and stroke findings in shanxi china and the us nhanes from 2011 to 2020 |
| topic | Heavy metals Stroke China NHANES |
| url | http://www.sciencedirect.com/science/article/pii/S014765132500421X |
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