Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities.
<h4>Objective</h4>Despite the common use of non-fasting measurements for lipid profile in children it remains unclear as to the extent non-fasting conditions have on laboratory results of lipids measurements. We aimed to assess the impact of non-fasting lipid profile on the occurrence of...
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
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| author | Lukasz Szternel Magdalena Krintus Katarzyna Bergmann Tadeusz Derezinski Grazyna Sypniewska |
| author_facet | Lukasz Szternel Magdalena Krintus Katarzyna Bergmann Tadeusz Derezinski Grazyna Sypniewska |
| author_sort | Lukasz Szternel |
| collection | DOAJ |
| description | <h4>Objective</h4>Despite the common use of non-fasting measurements for lipid profile in children it remains unclear as to the extent non-fasting conditions have on laboratory results of lipids measurements. We aimed to assess the impact of non-fasting lipid profile on the occurrence of dyslipidemia in children.<h4>Materials and methods</h4>Basic lipid profile including: total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG), as well as small, dense-LDL-C (sd-LDL-C), apolipoprotein AI (ApoAI), apolipoprotein B (ApoB) and lipoprotein(a) [Lp(a)], were measured in 289 presumably healthy children aged 9-11 in both fasting and non-fasting condition. The clinical impact of non-fasting lipid profile was evaluated individually for each child with estimation of false positive (FP) and false negative (FN) results.<h4>Results</h4>The highest percentage of FP results in non-fasting condition was observed for TG (42.3%) being significantly higher when compared to FN results (p = 0.003). In contrast, the highest percentage of FN results in a non-fasting state were shown for LDL-C (14.3%), but the difference was statistically insignificant when compared to FP results. When comparing fasting and non-fasting lipid profile a number of significant differences was shown for: TG (p<0.001), HDL-C (p = 0.002) LDL-C (p<0.001) and ApoAI (p<0.001), respectively. The occurrence of dyslipidemia, recognized on the basis of non-fasting lipids was significantly higher (p = 0.010) when compared to fasting lipid profile.<h4>Conclusions</h4>A higher occurrence of dyslipidemia, based on the measurement of non-fasting lipids in children, is suggestive of possible disorders in lipid metabolism. However, accurate identification of dyslipidemia by assessment of non-fasting lipids requires the establishment of appropriate cut-off values for children. |
| format | Article |
| id | doaj-art-724f469bfd504a61a9a6f76ee9caa11d |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-724f469bfd504a61a9a6f76ee9caa11d2025-08-20T03:12:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01136e019843310.1371/journal.pone.0198433Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities.Lukasz SzternelMagdalena KrintusKatarzyna BergmannTadeusz DerezinskiGrazyna Sypniewska<h4>Objective</h4>Despite the common use of non-fasting measurements for lipid profile in children it remains unclear as to the extent non-fasting conditions have on laboratory results of lipids measurements. We aimed to assess the impact of non-fasting lipid profile on the occurrence of dyslipidemia in children.<h4>Materials and methods</h4>Basic lipid profile including: total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG), as well as small, dense-LDL-C (sd-LDL-C), apolipoprotein AI (ApoAI), apolipoprotein B (ApoB) and lipoprotein(a) [Lp(a)], were measured in 289 presumably healthy children aged 9-11 in both fasting and non-fasting condition. The clinical impact of non-fasting lipid profile was evaluated individually for each child with estimation of false positive (FP) and false negative (FN) results.<h4>Results</h4>The highest percentage of FP results in non-fasting condition was observed for TG (42.3%) being significantly higher when compared to FN results (p = 0.003). In contrast, the highest percentage of FN results in a non-fasting state were shown for LDL-C (14.3%), but the difference was statistically insignificant when compared to FP results. When comparing fasting and non-fasting lipid profile a number of significant differences was shown for: TG (p<0.001), HDL-C (p = 0.002) LDL-C (p<0.001) and ApoAI (p<0.001), respectively. The occurrence of dyslipidemia, recognized on the basis of non-fasting lipids was significantly higher (p = 0.010) when compared to fasting lipid profile.<h4>Conclusions</h4>A higher occurrence of dyslipidemia, based on the measurement of non-fasting lipids in children, is suggestive of possible disorders in lipid metabolism. However, accurate identification of dyslipidemia by assessment of non-fasting lipids requires the establishment of appropriate cut-off values for children.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198433&type=printable |
| spellingShingle | Lukasz Szternel Magdalena Krintus Katarzyna Bergmann Tadeusz Derezinski Grazyna Sypniewska Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities. PLoS ONE |
| title | Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities. |
| title_full | Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities. |
| title_fullStr | Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities. |
| title_full_unstemmed | Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities. |
| title_short | Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities. |
| title_sort | non fasting lipid profile determination in presumably healthy children impact on the assessment of lipid abnormalities |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198433&type=printable |
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