Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity
Marina Gueçamburu,1 Axelle Dupont,2 Bernice Djidonou,3 Charlotte Thibaut de Ménonville,4 Leyla Barakat,5 Félix Laborier,5 Mathilde Le Brun,5 Clairelyne Dupin,5 Catherine Neukirch,5 Camille Taillé5 1Service des Maladies Respiratoires et des épreuves fonctionnelles respiratoires, Hôpital Haut Leveque,...
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Dove Medical Press
2025-05-01
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| author | Gueçamburu M Dupont A Djidonou B Thibaut de Ménonville C Barakat L Laborier F Le Brun M Dupin C Neukirch C Taillé C |
| author_facet | Gueçamburu M Dupont A Djidonou B Thibaut de Ménonville C Barakat L Laborier F Le Brun M Dupin C Neukirch C Taillé C |
| author_sort | Gueçamburu M |
| collection | DOAJ |
| description | Marina Gueçamburu,1 Axelle Dupont,2 Bernice Djidonou,3 Charlotte Thibaut de Ménonville,4 Leyla Barakat,5 Félix Laborier,5 Mathilde Le Brun,5 Clairelyne Dupin,5 Catherine Neukirch,5 Camille Taillé5 1Service des Maladies Respiratoires et des épreuves fonctionnelles respiratoires, Hôpital Haut Leveque, CHU Bordeaux, Pessac, 33604, France; 2Département d’épidémiologie et de recherche clinique, Hôpital Bichat, AP-HP Nord - Université Paris Cité, Paris, 75018, France; 3Service de Pneumologie, Centre Hospitalier Sud Francilien, Corbeil Essonnes, 91100, France; 4Service de Pneumologie, Hôpital Paris Saint Joseph, Paris, 75014, France; 5Service de pneumologie et centre de référence des maladies pulmonaires rares, Hôpital Bichat, AP-HP Nord - Université Paris Cité, Paris, 75018, FranceCorrespondence: Camille Taillé, Service de pneumologie et centre de référence des maladies pulmonaires rares Hôpital Bichat, AP-HP Nord - Université Paris Cité, Paris, 75018, France, Email camille.taille@aphp.frAim: The impact of sensitization on asthma outcomes in adults is still being discussed. This study aims to describe the sensitization profiles and allergic comorbidities of patients with severe asthma, and to analyze their association with asthma severity.Patients and Methods: This retrospective study included adult patients, evaluated at the Severe Asthma Clinic of Bichat University Hospital (Paris, France) during a 1-day hospital stay between May 2022 and January 2024. Sensitization, defined by a positive skin prick test and/or allergen-specific IgE levels greater than 0.10 kUA/L, was analysed alongside allergic comorbidities. The ASSESS score was used to grade asthma severity.Results: Of the 201 patients included, 142 (70.6%) exhibited at least one sensitization to an aeroallergen, of whom 38 (26.8%) were monosensitized, and 104 (73.2%) were polysensitized. Compared to polysensitized patients, monosensitized patients were older at diagnosis (years: 30.6 ± 20.1 vs 21.7 ± 17.6, p = 0.01), had a higher ASSESS score (median (Q1; Q3); 13 (11; 15) vs 11 (9; 14), p = 0.02), a lower pre-bronchodilator forced expiratory volume in 1 second (%pred: 70.3 ± 23.2 vs 79.3 ± 21.8, p = 0.03), and experienced a greater burden of exacerbations (p = 0.03). There were significantly more polysensitized patients with at least three allergic comorbidities, but the number of allergic comorbidities did not correlate with asthma severity.Conclusion: Monosensitized patients exhibited more severe disease and greater airway obstruction compared to polysensitized individuals. These findings suggest that allergies, especially in cases of late-onset asthma, may not be a significant determinant of asthma severity in adults.Keywords: severe asthma, sensitization, aeroallergens, allergy, ASSESS |
| format | Article |
| id | doaj-art-724b157990824c19b336d481e53db7c8 |
| institution | DOAJ |
| issn | 1178-6965 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj-art-724b157990824c19b336d481e53db7c82025-08-20T03:09:32ZengDove Medical PressJournal of Asthma and Allergy1178-69652025-05-01Volume 18Issue 1683694102629Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease SeverityGueçamburu M0Dupont A1Djidonou BThibaut de Ménonville C2Barakat LLaborier F3Le Brun M4Dupin C5Neukirch C6Taillé CPulmonologyClinical Research, Biostatistics and Epidemiology DepartmentPneumo-allergologiePneumologie AService de PneumologiePneumologie APneumologyMarina Gueçamburu,1 Axelle Dupont,2 Bernice Djidonou,3 Charlotte Thibaut de Ménonville,4 Leyla Barakat,5 Félix Laborier,5 Mathilde Le Brun,5 Clairelyne Dupin,5 Catherine Neukirch,5 Camille Taillé5 1Service des Maladies Respiratoires et des épreuves fonctionnelles respiratoires, Hôpital Haut Leveque, CHU Bordeaux, Pessac, 33604, France; 2Département d’épidémiologie et de recherche clinique, Hôpital Bichat, AP-HP Nord - Université Paris Cité, Paris, 75018, France; 3Service de Pneumologie, Centre Hospitalier Sud Francilien, Corbeil Essonnes, 91100, France; 4Service de Pneumologie, Hôpital Paris Saint Joseph, Paris, 75014, France; 5Service de pneumologie et centre de référence des maladies pulmonaires rares, Hôpital Bichat, AP-HP Nord - Université Paris Cité, Paris, 75018, FranceCorrespondence: Camille Taillé, Service de pneumologie et centre de référence des maladies pulmonaires rares Hôpital Bichat, AP-HP Nord - Université Paris Cité, Paris, 75018, France, Email camille.taille@aphp.frAim: The impact of sensitization on asthma outcomes in adults is still being discussed. This study aims to describe the sensitization profiles and allergic comorbidities of patients with severe asthma, and to analyze their association with asthma severity.Patients and Methods: This retrospective study included adult patients, evaluated at the Severe Asthma Clinic of Bichat University Hospital (Paris, France) during a 1-day hospital stay between May 2022 and January 2024. Sensitization, defined by a positive skin prick test and/or allergen-specific IgE levels greater than 0.10 kUA/L, was analysed alongside allergic comorbidities. The ASSESS score was used to grade asthma severity.Results: Of the 201 patients included, 142 (70.6%) exhibited at least one sensitization to an aeroallergen, of whom 38 (26.8%) were monosensitized, and 104 (73.2%) were polysensitized. Compared to polysensitized patients, monosensitized patients were older at diagnosis (years: 30.6 ± 20.1 vs 21.7 ± 17.6, p = 0.01), had a higher ASSESS score (median (Q1; Q3); 13 (11; 15) vs 11 (9; 14), p = 0.02), a lower pre-bronchodilator forced expiratory volume in 1 second (%pred: 70.3 ± 23.2 vs 79.3 ± 21.8, p = 0.03), and experienced a greater burden of exacerbations (p = 0.03). There were significantly more polysensitized patients with at least three allergic comorbidities, but the number of allergic comorbidities did not correlate with asthma severity.Conclusion: Monosensitized patients exhibited more severe disease and greater airway obstruction compared to polysensitized individuals. These findings suggest that allergies, especially in cases of late-onset asthma, may not be a significant determinant of asthma severity in adults.Keywords: severe asthma, sensitization, aeroallergens, allergy, ASSESShttps://www.dovepress.com/monosensitization-vs-polysensitization-in-severe-asthma-implications-f-peer-reviewed-fulltext-article-JAAsevere asthmasensitizationaeroallergensallergyASSESS |
| spellingShingle | Gueçamburu M Dupont A Djidonou B Thibaut de Ménonville C Barakat L Laborier F Le Brun M Dupin C Neukirch C Taillé C Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity Journal of Asthma and Allergy severe asthma sensitization aeroallergens allergy ASSESS |
| title | Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity |
| title_full | Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity |
| title_fullStr | Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity |
| title_full_unstemmed | Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity |
| title_short | Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity |
| title_sort | monosensitization vs polysensitization in severe asthma implications for disease severity |
| topic | severe asthma sensitization aeroallergens allergy ASSESS |
| url | https://www.dovepress.com/monosensitization-vs-polysensitization-in-severe-asthma-implications-f-peer-reviewed-fulltext-article-JAA |
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