Irisin suppresses PDGF-BB-induced proliferation of vascular smooth muscle cells <i>in vitro</i> by activating AMPK/mTOR-mediated autophagy

Irisin suppresses PDGF-BB-induced proliferation of vascular smooth muscle cells <i>in vitro</i> by activating AMPK/mTOR-mediated autophagy

Restenosis is a pivotal factor that restricts the efficacy of coronary artery bypass grafting. Inhibition of vascular smooth muscle cells (VSMCs) proliferation can improve intimal hyperplasia and lumen stenosis. Irisin, a polypeptide secreted by muscle cells, has been demonstrated to have a protect...

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Bibliographic Details
Main Authors: Fenqiang Qi, Yuxin Deng, Wei Huang, Yanli Cai, Kelin Hong, Shui Xiang
Format: Article
Language:English
Published: PAGEPress Publications 2024-10-01
Series:European Journal of Histochemistry
Subjects:
Vascular smooth muscle cells
irisin
cell proliferation
autophagy
AMPK/mTOR signaling pathway
Online Access:https://www.ejh.it/ejh/article/view/4104
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