Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration
Artificial implants have consistently been recognized as the most effective clinical strategy for repairing bone fractures and defects, particularly in orthopedics and stomatology. Nowadays, the focus of bone repair has shifted from basic fixation and structural restoration to the reconstruction of...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-09-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25001914 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849249643966234624 |
|---|---|
| author | Shishuo Li Zhentao Man Kangqing Zuo Linbo Zhang Taixing Zhang Guiyong Xiao Yupeng Lu Wei Li Ningbo Li |
| author_facet | Shishuo Li Zhentao Man Kangqing Zuo Linbo Zhang Taixing Zhang Guiyong Xiao Yupeng Lu Wei Li Ningbo Li |
| author_sort | Shishuo Li |
| collection | DOAJ |
| description | Artificial implants have consistently been recognized as the most effective clinical strategy for repairing bone fractures and defects, particularly in orthopedics and stomatology. Nowadays, the focus of bone repair has shifted from basic fixation and structural restoration to the reconstruction of multifunctional “live” tissue to mimic the natural bone microenvironment. However, developing the smart implants with ideal osteogenesis-related multi-functions remains challenging, as the effects of physicochemical properties of implant materials on intracellular signaling, stem cell niches, and tissue regeneration are not yet fully understood. Herein, we systematically explore recent advancements in innovative strategies for bone repair and regeneration, revealing the significance of the smart implants that closely mimic the natural structure and function of bone tissue. Adaptation to patient-oriented osteogenic microenvironments, dynamic osteoblastogenesis-osteoclastogenesis balance, antibacterial/bactericidal capacity, vascularization, and osteoimmunomodulatory capacity and their regulatory mechanisms achieved by biomaterials design and functional modifications are thoroughly summarized and analyzed. Notably, the popular research on multifunctional platforms with synergetic interactions between different functions and treatment of complex clinical issues, including the emerging neurogenic bone repair, is also significantly discussed for developing more intelligent implants. By summarizing recent research efforts, this review proposes the latest multifunctional strategies and synergistic mechanisms of smart bone implants, aiming to provide better bone defect repair applications that more closely mimic the natural bone tissue. |
| format | Article |
| id | doaj-art-723be39d57ff4524b46c115cbef370ab |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-723be39d57ff4524b46c115cbef370ab2025-08-20T03:57:31ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-09-015133338210.1016/j.bioactmat.2025.05.004Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regenerationShishuo Li0Zhentao Man1Kangqing Zuo2Linbo Zhang3Taixing Zhang4Guiyong Xiao5Yupeng Lu6Wei Li7Ningbo Li8Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China; School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR China; Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China; Graduate School of Dalian Medical University, Dalian, Liaoning Province, 116044, PR China; Department of Orthopedics, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, Jiangsu Province, 213003, PR ChinaDepartment of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China; College of Sports Medicine and Rehabilitation, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250021, PR China; Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong Institute of Endocrine and Metabolic Diseases, Ji'nan, Shandong, 250062, PR ChinaDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China; School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR ChinaDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China; School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR ChinaDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China; School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR ChinaKey Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Ji'nan, 250061, PR China; School of Materials Science and Engineering, Shandong University, Ji'nan, 250061, PR ChinaKey Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Ji'nan, 250061, PR China; School of Materials Science and Engineering, Shandong University, Ji'nan, 250061, PR China; Corresponding author. Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Ji'nan, 250061, PR China.Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China; College of Sports Medicine and Rehabilitation, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250021, PR China; Corresponding author. Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China; School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR China; Corresponding author. Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.Artificial implants have consistently been recognized as the most effective clinical strategy for repairing bone fractures and defects, particularly in orthopedics and stomatology. Nowadays, the focus of bone repair has shifted from basic fixation and structural restoration to the reconstruction of multifunctional “live” tissue to mimic the natural bone microenvironment. However, developing the smart implants with ideal osteogenesis-related multi-functions remains challenging, as the effects of physicochemical properties of implant materials on intracellular signaling, stem cell niches, and tissue regeneration are not yet fully understood. Herein, we systematically explore recent advancements in innovative strategies for bone repair and regeneration, revealing the significance of the smart implants that closely mimic the natural structure and function of bone tissue. Adaptation to patient-oriented osteogenic microenvironments, dynamic osteoblastogenesis-osteoclastogenesis balance, antibacterial/bactericidal capacity, vascularization, and osteoimmunomodulatory capacity and their regulatory mechanisms achieved by biomaterials design and functional modifications are thoroughly summarized and analyzed. Notably, the popular research on multifunctional platforms with synergetic interactions between different functions and treatment of complex clinical issues, including the emerging neurogenic bone repair, is also significantly discussed for developing more intelligent implants. By summarizing recent research efforts, this review proposes the latest multifunctional strategies and synergistic mechanisms of smart bone implants, aiming to provide better bone defect repair applications that more closely mimic the natural bone tissue.http://www.sciencedirect.com/science/article/pii/S2452199X25001914Smart bone implantsOsteogenesisMultifunctional strategySynergistic mechanismNeurogenic bone repair |
| spellingShingle | Shishuo Li Zhentao Man Kangqing Zuo Linbo Zhang Taixing Zhang Guiyong Xiao Yupeng Lu Wei Li Ningbo Li Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration Bioactive Materials Smart bone implants Osteogenesis Multifunctional strategy Synergistic mechanism Neurogenic bone repair |
| title | Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration |
| title_full | Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration |
| title_fullStr | Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration |
| title_full_unstemmed | Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration |
| title_short | Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration |
| title_sort | advancement in smart bone implants the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration |
| topic | Smart bone implants Osteogenesis Multifunctional strategy Synergistic mechanism Neurogenic bone repair |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25001914 |
| work_keys_str_mv | AT shishuoli advancementinsmartboneimplantsthelatestmultifunctionalstrategiesandsynergisticmechanismsfortissuerepairandregeneration AT zhentaoman advancementinsmartboneimplantsthelatestmultifunctionalstrategiesandsynergisticmechanismsfortissuerepairandregeneration AT kangqingzuo advancementinsmartboneimplantsthelatestmultifunctionalstrategiesandsynergisticmechanismsfortissuerepairandregeneration AT linbozhang advancementinsmartboneimplantsthelatestmultifunctionalstrategiesandsynergisticmechanismsfortissuerepairandregeneration AT taixingzhang advancementinsmartboneimplantsthelatestmultifunctionalstrategiesandsynergisticmechanismsfortissuerepairandregeneration AT guiyongxiao advancementinsmartboneimplantsthelatestmultifunctionalstrategiesandsynergisticmechanismsfortissuerepairandregeneration AT yupenglu advancementinsmartboneimplantsthelatestmultifunctionalstrategiesandsynergisticmechanismsfortissuerepairandregeneration AT weili advancementinsmartboneimplantsthelatestmultifunctionalstrategiesandsynergisticmechanismsfortissuerepairandregeneration AT ningboli advancementinsmartboneimplantsthelatestmultifunctionalstrategiesandsynergisticmechanismsfortissuerepairandregeneration |