Comparative evaluation of intrathecal hyperbaric 0.75% ropivacaine with hyperbaric 0.5% bupivacaine in lower limb orthopaedic surgeries: A prospective randomized double blind study
Background and Aims: Recently, hyperbaric 0.75% ropivacaine has been made commercially available. We planned this study to compare the effect of intrathecal hyperbaric 0.75% ropivacaine and hyperbaric 0.5% bupivacaine in spinal anesthesia for lower limb orthopedic surgeries. Materials and Methods: P...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | The Indian Anaesthetists' Forum |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/TheIAForum.TheIAForum_71_24 |
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| Summary: | Background and Aims:
Recently, hyperbaric 0.75% ropivacaine has been made commercially available. We planned this study to compare the effect of intrathecal hyperbaric 0.75% ropivacaine and hyperbaric 0.5% bupivacaine in spinal anesthesia for lower limb orthopedic surgeries.
Materials and Methods:
Patients were randomly allocated into 2 groups of 40 patients each – -Group B and R to receive subarachnoid block with 0.5% hyperbaric bupivacaine 15 mg and 0.75% hyperbaric ropivacaine 22.5 mg, respectively. The primary outcome measured was the duration of analgesia. Secondary outcomes measured were onset and duration of sensory-motor block, peak sensory level attained, degree of motor block, time to micturition, and hemodynamic parameters. Categorical, continuous, and ordinal data were presented as number (proportion), mean ± standard deviation and median interquartile range, respectively. Chi-square test, t-test, and Mann–Whitney U-test were applied where deemed appropriate. P < 0.05 was considered statistically significant.
Results:
Duration of analgesia and sensory and motor block were lesser in ropivacaine group. Mean time for the onset of sensory-motor block was faster in Group B. Patients in ropivacaine group exhibited a shorter time to micturition and a lesser degree of motor block as compared to bupivacaine group. Median peak sensory level and hemodynamic parameters in both groups were statistically comparable.
Conclusion:
Despite a slower onset time of block and reduced duration of analgesia, intrathecal hyperbaric ropivacaine provides a better alternative to intrathecal hyperbaric bupivacaine for lower limb orthopedic surgeries by providing a shorter duration of sensorimotor block, a lesser degree of motor block, shorter time to first micturition, and a stable hemodynamic profile, thus allowing early ambulation. |
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| ISSN: | 0973-0311 |