A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome
The potentialities to apply mesenchymal stem cells (MSCs) in regenerative medicine have been extensively studied over the last decades. In the cardiovascular disease (CVD) field, MSCs-based therapy is the subject of great expectations. Its therapeutic potential has been already shown in several prec...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/765846 |
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| author | Clara Gallina Valentina Turinetto Claudia Giachino |
| author_facet | Clara Gallina Valentina Turinetto Claudia Giachino |
| author_sort | Clara Gallina |
| collection | DOAJ |
| description | The potentialities to apply mesenchymal stem cells (MSCs) in regenerative medicine have been extensively studied over the last decades. In the cardiovascular disease (CVD) field, MSCs-based therapy is the subject of great expectations. Its therapeutic potential has been already shown in several preclinical models and both the safety and efficacy of MSCs-based therapy are being evaluated in humans. It is now clear that the predominant mechanism by which MSCs participate in heart tissue repair is through a paracrine activity. Via the production of a multitude of trophic factors endowed with different properties, MSCs can reduce tissue injury, protect tissue from further adverse effects, and enhance tissue repair. The present review discusses the current understanding of the MSCs secretome as a therapy for treatment of CVD. We provide insights into the possible employment of the MSCs secretome and their released extracellular vesicles as novel approaches for cardiac regeneration that would have certain advantages over injection of living cells. |
| format | Article |
| id | doaj-art-7232000c685540d2bd0c169f2eaae461 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-7232000c685540d2bd0c169f2eaae4612025-02-03T01:30:27ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/765846765846A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell SecretomeClara Gallina0Valentina Turinetto1Claudia Giachino2Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, 10043 Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, 10043 Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, 10043 Turin, ItalyThe potentialities to apply mesenchymal stem cells (MSCs) in regenerative medicine have been extensively studied over the last decades. In the cardiovascular disease (CVD) field, MSCs-based therapy is the subject of great expectations. Its therapeutic potential has been already shown in several preclinical models and both the safety and efficacy of MSCs-based therapy are being evaluated in humans. It is now clear that the predominant mechanism by which MSCs participate in heart tissue repair is through a paracrine activity. Via the production of a multitude of trophic factors endowed with different properties, MSCs can reduce tissue injury, protect tissue from further adverse effects, and enhance tissue repair. The present review discusses the current understanding of the MSCs secretome as a therapy for treatment of CVD. We provide insights into the possible employment of the MSCs secretome and their released extracellular vesicles as novel approaches for cardiac regeneration that would have certain advantages over injection of living cells.http://dx.doi.org/10.1155/2015/765846 |
| spellingShingle | Clara Gallina Valentina Turinetto Claudia Giachino A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome Stem Cells International |
| title | A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome |
| title_full | A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome |
| title_fullStr | A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome |
| title_full_unstemmed | A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome |
| title_short | A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome |
| title_sort | new paradigm in cardiac regeneration the mesenchymal stem cell secretome |
| url | http://dx.doi.org/10.1155/2015/765846 |
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