Multifunctional Evaluation of Graphene Oxide–Sulfonamide Nanoconjugates: Antimicrobial, Antibiofilm, Cytocompatibility and Xenobiotic Metabolism Gene Expression Insight

Multifunctional Evaluation of Graphene Oxide–Sulfonamide Nanoconjugates: Antimicrobial, Antibiofilm, Cytocompatibility and Xenobiotic Metabolism Gene Expression Insight

The clinical utility of sulfonamide antibiotics is increasingly challenged by antimicrobial resistance and pharmacokinetic limitations. In this study, we synthesized five graphene oxide–sulfonamide nanoconjugates (GO–S1 to GO–S5) via covalent functionalization, comprehensively characterized them by...

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Main Authors: Irina Zarafu, Irina Mușat, Carmen Limban, Diana C. Nuță, Ioana Daniela Dulama, Cristiana Radulescu, Raluca Maria Stirbescu, Arnaud Tatibouet, Carmen M. Chifiriuc, Luminita Marutescu, Marcela Popa, Laura D. Dragu, Elena Radu, Ioana Nicolau, Coralia Bleotu, Petre Ionita
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
graphene oxide
sulfonamide
antimicrobial
apoptosis
cell cycle
cytochrome P450
Online Access:https://www.mdpi.com/1420-3049/30/12/2585
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