Factor H binding protein (FHbp): An evaluation of genotypic diversity across Neisseria meningitidis serogroups
Neisseria meningitidis serogroups A, B, C, W, X, and Y cause invasive meningococcal disease (IMD) worldwide. Factor H binding protein (FHbp), a key meningococcal virulence factor, is an antigen included in both licensed meningococcal serogroup B (MenB) vaccines. This review examines the biology and...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2409502 |
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| author | Zhenghui Li Ashlesh Krishna Murthy Li Hao Lubomira Andrew Annaliesa S. Anderson |
| author_facet | Zhenghui Li Ashlesh Krishna Murthy Li Hao Lubomira Andrew Annaliesa S. Anderson |
| author_sort | Zhenghui Li |
| collection | DOAJ |
| description | Neisseria meningitidis serogroups A, B, C, W, X, and Y cause invasive meningococcal disease (IMD) worldwide. Factor H binding protein (FHbp), a key meningococcal virulence factor, is an antigen included in both licensed meningococcal serogroup B (MenB) vaccines. This review examines the biology and epidemiology of FHbp and assesses the ability and potential of FHbp vaccine antigens to protect against IMD. Using evidence from the literature and the contemporary PubMLST database, we discuss analyses of MenB genotypes on the representation of the most prevalent multilocus sequence typing (MLST)/clonal complexes, FHbp subfamily distribution, and FHbp and porin A (PorA) variants. We further discuss that the similar genotypes, distribution, and diversity of FHbp variant types have remained stable over long time periods, supporting the potential for FHbp-containing, protein-based vaccines to protect against IMD, including MenB-FHbp (Trumenba®), which contains two lipidated FHbp antigens (one each from both FHbp subfamilies: A and B). |
| format | Article |
| id | doaj-art-72271bbcb41947e1af1ece601ad1857a |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-72271bbcb41947e1af1ece601ad1857a2025-08-20T03:22:19ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2409502Factor H binding protein (FHbp): An evaluation of genotypic diversity across Neisseria meningitidis serogroupsZhenghui Li0Ashlesh Krishna Murthy1Li Hao2Lubomira Andrew3Annaliesa S. Anderson4Pfizer Vaccine Research and Development, Pfizer Inc, Pearl River, NY, USAPfizer Vaccine Research and Development, Pfizer Inc, Pearl River, NY, USAPfizer Vaccine Research and Development, Pfizer Inc, Pearl River, NY, USAPfizer Vaccine Research and Development, Pfizer Inc, Pearl River, NY, USAPfizer Vaccine Research and Development, Pfizer Inc, Pearl River, NY, USANeisseria meningitidis serogroups A, B, C, W, X, and Y cause invasive meningococcal disease (IMD) worldwide. Factor H binding protein (FHbp), a key meningococcal virulence factor, is an antigen included in both licensed meningococcal serogroup B (MenB) vaccines. This review examines the biology and epidemiology of FHbp and assesses the ability and potential of FHbp vaccine antigens to protect against IMD. Using evidence from the literature and the contemporary PubMLST database, we discuss analyses of MenB genotypes on the representation of the most prevalent multilocus sequence typing (MLST)/clonal complexes, FHbp subfamily distribution, and FHbp and porin A (PorA) variants. We further discuss that the similar genotypes, distribution, and diversity of FHbp variant types have remained stable over long time periods, supporting the potential for FHbp-containing, protein-based vaccines to protect against IMD, including MenB-FHbp (Trumenba®), which contains two lipidated FHbp antigens (one each from both FHbp subfamilies: A and B).https://www.tandfonline.com/doi/10.1080/21645515.2024.2409502Vaccinesinvasive meningococcal diseasefactor H binding proteingenotypic diversityclonal complexNeisseria meningitidis |
| spellingShingle | Zhenghui Li Ashlesh Krishna Murthy Li Hao Lubomira Andrew Annaliesa S. Anderson Factor H binding protein (FHbp): An evaluation of genotypic diversity across Neisseria meningitidis serogroups Human Vaccines & Immunotherapeutics Vaccines invasive meningococcal disease factor H binding protein genotypic diversity clonal complex Neisseria meningitidis |
| title | Factor H binding protein (FHbp): An evaluation of genotypic diversity across Neisseria meningitidis serogroups |
| title_full | Factor H binding protein (FHbp): An evaluation of genotypic diversity across Neisseria meningitidis serogroups |
| title_fullStr | Factor H binding protein (FHbp): An evaluation of genotypic diversity across Neisseria meningitidis serogroups |
| title_full_unstemmed | Factor H binding protein (FHbp): An evaluation of genotypic diversity across Neisseria meningitidis serogroups |
| title_short | Factor H binding protein (FHbp): An evaluation of genotypic diversity across Neisseria meningitidis serogroups |
| title_sort | factor h binding protein fhbp an evaluation of genotypic diversity across neisseria meningitidis serogroups |
| topic | Vaccines invasive meningococcal disease factor H binding protein genotypic diversity clonal complex Neisseria meningitidis |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2409502 |
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