Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by inflammatory cell infiltration, synovial inflammation, and cartilage destruction. Proliferative fibroblast-like synoviocytes (FLS) play crucial roles in both propagation of inflammation and joint damage because of...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3906108 |
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| author | Qing-Zhu Kong Li-Tao Guo Jia-Ning Yang Yan-Fei Wang Jing-Xin Zhao Su-Hong Kong Meng Zhang Shi Yan Yu Jin |
| author_facet | Qing-Zhu Kong Li-Tao Guo Jia-Ning Yang Yan-Fei Wang Jing-Xin Zhao Su-Hong Kong Meng Zhang Shi Yan Yu Jin |
| author_sort | Qing-Zhu Kong |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by inflammatory cell infiltration, synovial inflammation, and cartilage destruction. Proliferative fibroblast-like synoviocytes (FLS) play crucial roles in both propagation of inflammation and joint damage because of their production of great amount of proinflammatory cytokines and proteolytic enzymes. In this study, we investigate the role of TRAF-interacting protein (TRIP) in regulating inflammatory process in RA-FLS. TRIP expression was attenuated in RA-FLS compared with osteoarthritis- (OA-) FLS. Overexpression of TRIP significantly inhibited the activation of NF-κB signaling and decreased the production of proinflammatory cytokines and matrix metalloproteinases (MMPs) in TNFα-stimulated RA-FLS. Furthermore, TRIP was found to interact with transforming growth factor β-activated kinase 1 (TAK1) and promoting K48-linked polyubiquitination of TAK1 in RA-FLS. Our results demonstrate that TRIP has anti-inflammatory effects on RA-FLS and suggest TRIP as a potential therapeutic target for human RA. |
| format | Article |
| id | doaj-art-7220fc90e8814e048e036d82d8ddedb0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7220fc90e8814e048e036d82d8ddedb02025-08-20T03:33:43ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/39061083906108Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like SynoviocytesQing-Zhu Kong0Li-Tao Guo1Jia-Ning Yang2Yan-Fei Wang3Jing-Xin Zhao4Su-Hong Kong5Meng Zhang6Shi Yan7Yu Jin8Department of Orthopedic Trauma, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 06700, ChinaDepartment of Ophthalmology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 06700, ChinaDepartment of Spinal Surgery, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 06700, ChinaDepartment of Emergency, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 06700, ChinaDepartment of Orthopedic Trauma, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 06700, ChinaDepartment of Gynaecology and Obstetrics, Maternal and Child Health Care Hospital of Longhua County, Chengde, Hebei 068150, ChinaDepartment of Emergency, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 06700, ChinaDepartment of Orthopedic Trauma, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 06700, ChinaDepartment of Orthopedic Trauma, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 06700, ChinaRheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by inflammatory cell infiltration, synovial inflammation, and cartilage destruction. Proliferative fibroblast-like synoviocytes (FLS) play crucial roles in both propagation of inflammation and joint damage because of their production of great amount of proinflammatory cytokines and proteolytic enzymes. In this study, we investigate the role of TRAF-interacting protein (TRIP) in regulating inflammatory process in RA-FLS. TRIP expression was attenuated in RA-FLS compared with osteoarthritis- (OA-) FLS. Overexpression of TRIP significantly inhibited the activation of NF-κB signaling and decreased the production of proinflammatory cytokines and matrix metalloproteinases (MMPs) in TNFα-stimulated RA-FLS. Furthermore, TRIP was found to interact with transforming growth factor β-activated kinase 1 (TAK1) and promoting K48-linked polyubiquitination of TAK1 in RA-FLS. Our results demonstrate that TRIP has anti-inflammatory effects on RA-FLS and suggest TRIP as a potential therapeutic target for human RA.http://dx.doi.org/10.1155/2016/3906108 |
| spellingShingle | Qing-Zhu Kong Li-Tao Guo Jia-Ning Yang Yan-Fei Wang Jing-Xin Zhao Su-Hong Kong Meng Zhang Shi Yan Yu Jin Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes Mediators of Inflammation |
| title | Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes |
| title_full | Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes |
| title_fullStr | Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes |
| title_full_unstemmed | Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes |
| title_short | Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes |
| title_sort | anti inflammatory effects of traf interacting protein in rheumatoid arthritis fibroblast like synoviocytes |
| url | http://dx.doi.org/10.1155/2016/3906108 |
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