Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity.
<h4>Background</h4>The influenza A virus is an RNA virus that is responsible for seasonal epidemics worldwide with up to five million cases of severe illness and 500,000 deaths annually according to the World Health Organization estimates. The factors associated with severe diseases are...
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Public Library of Science (PLoS)
2014-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0111640 |
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| author | Long Truong Hoang Thomas Tolfvenstam Eng Eong Ooi Chiea Chuen Khor Ahmand Nazri Mohamed Naim Eliza Xin Pei Ho Swee Hoe Ong Heiman F Wertheim Annette Fox Chau Van Vinh Nguyen Ngoc My Nghiem Tuan Manh Ha Anh Thi Ngoc Tran Paul Tambayah Raymond Lin Chariya Sangsajja Weerawat Manosuthi Chareon Chuchottaworn Piamlarp Sansayunh Tawee Chotpitayasunondh Piyarat Suntarattiwong Kulkanya Chokephaibulkit Pilaipan Puthavathana Menno D de Jong Jeremy Farrar H Rogier van Doorn Martin Lloyd Hibberd |
| author_facet | Long Truong Hoang Thomas Tolfvenstam Eng Eong Ooi Chiea Chuen Khor Ahmand Nazri Mohamed Naim Eliza Xin Pei Ho Swee Hoe Ong Heiman F Wertheim Annette Fox Chau Van Vinh Nguyen Ngoc My Nghiem Tuan Manh Ha Anh Thi Ngoc Tran Paul Tambayah Raymond Lin Chariya Sangsajja Weerawat Manosuthi Chareon Chuchottaworn Piamlarp Sansayunh Tawee Chotpitayasunondh Piyarat Suntarattiwong Kulkanya Chokephaibulkit Pilaipan Puthavathana Menno D de Jong Jeremy Farrar H Rogier van Doorn Martin Lloyd Hibberd |
| author_sort | Long Truong Hoang |
| collection | DOAJ |
| description | <h4>Background</h4>The influenza A virus is an RNA virus that is responsible for seasonal epidemics worldwide with up to five million cases of severe illness and 500,000 deaths annually according to the World Health Organization estimates. The factors associated with severe diseases are not well defined, but more severe disease is more often seen among persons aged >65 years, infants, pregnant women, and individuals of any age with underlying health conditions.<h4>Methodology/principal findings</h4>Using gene expression microarrays, the transcriptomic profiles of influenza-infected patients with severe (N = 11), moderate (N = 40) and mild (N = 83) symptoms were compared with the febrile patients of unknown etiology (N = 73). We found that influenza-infected patients, regardless of their clinical outcomes, had a stronger induction of antiviral and cytokine responses and a stronger attenuation of NK and T cell responses in comparison with those with unknown etiology. More importantly, we found that both interferon and ubiquitination signaling were strongly attenuated in patients with the most severe outcomes in comparison with those with moderate and mild outcomes, suggesting the protective roles of these pathways in disease pathogenesis.<h4>Conclusion/significances</h4>The attenuation of interferon and ubiquitination pathways may associate with the clinical outcomes of influenza patients. |
| format | Article |
| id | doaj-art-721c5ac7ea8b4dca80771467ae2821e3 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-721c5ac7ea8b4dca80771467ae2821e32025-08-20T03:10:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11164010.1371/journal.pone.0111640Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity.Long Truong HoangThomas TolfvenstamEng Eong OoiChiea Chuen KhorAhmand Nazri Mohamed NaimEliza Xin Pei HoSwee Hoe OngHeiman F WertheimAnnette FoxChau Van Vinh NguyenNgoc My NghiemTuan Manh HaAnh Thi Ngoc TranPaul TambayahRaymond LinChariya SangsajjaWeerawat ManosuthiChareon ChuchottawornPiamlarp SansayunhTawee ChotpitayasunondhPiyarat SuntarattiwongKulkanya ChokephaibulkitPilaipan PuthavathanaMenno D de JongJeremy FarrarH Rogier van DoornMartin Lloyd Hibberd<h4>Background</h4>The influenza A virus is an RNA virus that is responsible for seasonal epidemics worldwide with up to five million cases of severe illness and 500,000 deaths annually according to the World Health Organization estimates. The factors associated with severe diseases are not well defined, but more severe disease is more often seen among persons aged >65 years, infants, pregnant women, and individuals of any age with underlying health conditions.<h4>Methodology/principal findings</h4>Using gene expression microarrays, the transcriptomic profiles of influenza-infected patients with severe (N = 11), moderate (N = 40) and mild (N = 83) symptoms were compared with the febrile patients of unknown etiology (N = 73). We found that influenza-infected patients, regardless of their clinical outcomes, had a stronger induction of antiviral and cytokine responses and a stronger attenuation of NK and T cell responses in comparison with those with unknown etiology. More importantly, we found that both interferon and ubiquitination signaling were strongly attenuated in patients with the most severe outcomes in comparison with those with moderate and mild outcomes, suggesting the protective roles of these pathways in disease pathogenesis.<h4>Conclusion/significances</h4>The attenuation of interferon and ubiquitination pathways may associate with the clinical outcomes of influenza patients.https://doi.org/10.1371/journal.pone.0111640 |
| spellingShingle | Long Truong Hoang Thomas Tolfvenstam Eng Eong Ooi Chiea Chuen Khor Ahmand Nazri Mohamed Naim Eliza Xin Pei Ho Swee Hoe Ong Heiman F Wertheim Annette Fox Chau Van Vinh Nguyen Ngoc My Nghiem Tuan Manh Ha Anh Thi Ngoc Tran Paul Tambayah Raymond Lin Chariya Sangsajja Weerawat Manosuthi Chareon Chuchottaworn Piamlarp Sansayunh Tawee Chotpitayasunondh Piyarat Suntarattiwong Kulkanya Chokephaibulkit Pilaipan Puthavathana Menno D de Jong Jeremy Farrar H Rogier van Doorn Martin Lloyd Hibberd Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity. PLoS ONE |
| title | Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity. |
| title_full | Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity. |
| title_fullStr | Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity. |
| title_full_unstemmed | Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity. |
| title_short | Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity. |
| title_sort | patient based transcriptome wide analysis identify interferon and ubiquination pathways as potential predictors of influenza a disease severity |
| url | https://doi.org/10.1371/journal.pone.0111640 |
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