Integrating multi-omics and experimental techniques to decode ubiquitinated protein modifications in hepatocellular carcinoma

Integrating multi-omics and experimental techniques to decode ubiquitinated protein modifications in hepatocellular carcinoma

BackgroundUbiquitination, a critical post-translational modification, plays a pivotal role in regulating protein stability and activity, influencing various aspects of cancer development, including metabolic reprogramming, immune evasion, and tumor progression. However, the specific role of ubiquiti...

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Bibliographic Details
Main Authors: Haikun Yang, Yuan Chen, Zheng Zhou, Yanjing Wang, Peng Li, Yang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
UBE2C
ubiquitination
tumor cells
immune regulation
prognosis
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1545472/full
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