Catalase‐Encapsulated Nanoparticles via Surface Radical Polymerization for Periodontitis Therapy
Abstract Periodontitis is a prevalent chronic inflammatory disease characterized by oxidative stress and excessive production of reactive oxygen species (ROS), leading to the destruction of periodontal tissues. Despite existing treatments, the management of periodontitis remains challenging due to i...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-06-01
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| Series: | Macromolecular Materials and Engineering |
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| Online Access: | https://doi.org/10.1002/mame.202500022 |
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| author | Tongtong Yan Xiang Li Shiqun Sun Yuchao Luo Haotian Shi Nan Yang Xue Ren Wenjing Tian Zhihui Liu Bin Xu |
| author_facet | Tongtong Yan Xiang Li Shiqun Sun Yuchao Luo Haotian Shi Nan Yang Xue Ren Wenjing Tian Zhihui Liu Bin Xu |
| author_sort | Tongtong Yan |
| collection | DOAJ |
| description | Abstract Periodontitis is a prevalent chronic inflammatory disease characterized by oxidative stress and excessive production of reactive oxygen species (ROS), leading to the destruction of periodontal tissues. Despite existing treatments, the management of periodontitis remains challenging due to inadequate control of inflammation and poor tissue regeneration. In this study, a novel therapeutic strategy is developed by encapsulating catalase (CAT) within polyacrylamide (PAAM)‐based nanoparticles (CAT NPs) through surface radical polymerization to enhance its stability and efficacy in the inflammatory environment of periodontal tissues. The PAAM polymer shell serves as a protective barrier to isolate CAT from interactions with proteolytic enzymes and inflammatory mediators in the periodontal microenvironment, thereby preventing structural denaturation and enhancing enzymatic stability. This approach targets the reduction of ROS levels and the modulation of the Nrf‐2/HO‐1 antioxidant pathway, key mediators in oxidative stress responses. In vitro and in vivo studies demonstrated that CAT NPs significantly alleviate oxidative stress, reduce pro‐inflammatory cytokines, and promote periodontal tissue regeneration. Compared to conventional treatments, CAT NPs exhibit superior therapeutic outcomes, offering a promising and long‐lasting solution for the treatment of periodontitis. This innovative strategy provides new avenues for the development of more effective periodontitis therapies. |
| format | Article |
| id | doaj-art-721b1e86c0ee4b8d986a5fa7da43a056 |
| institution | DOAJ |
| issn | 1438-7492 1439-2054 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Macromolecular Materials and Engineering |
| spelling | doaj-art-721b1e86c0ee4b8d986a5fa7da43a0562025-08-20T02:39:25ZengWiley-VCHMacromolecular Materials and Engineering1438-74921439-20542025-06-013106n/an/a10.1002/mame.202500022Catalase‐Encapsulated Nanoparticles via Surface Radical Polymerization for Periodontitis TherapyTongtong Yan0Xiang Li1Shiqun Sun2Yuchao Luo3Haotian Shi4Nan Yang5Xue Ren6Wenjing Tian7Zhihui Liu8Bin Xu9Department of Prosthodontics Hospital of Stomatology Jilin University Changchun ChinaState Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 ChinaDepartment of Prosthodontics Hospital of Stomatology Jilin University Changchun ChinaState Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 ChinaState Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 ChinaDepartment of Prosthodontics Hospital of Stomatology Jilin University Changchun ChinaState Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 ChinaState Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 ChinaDepartment of Prosthodontics Hospital of Stomatology Jilin University Changchun ChinaState Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 ChinaAbstract Periodontitis is a prevalent chronic inflammatory disease characterized by oxidative stress and excessive production of reactive oxygen species (ROS), leading to the destruction of periodontal tissues. Despite existing treatments, the management of periodontitis remains challenging due to inadequate control of inflammation and poor tissue regeneration. In this study, a novel therapeutic strategy is developed by encapsulating catalase (CAT) within polyacrylamide (PAAM)‐based nanoparticles (CAT NPs) through surface radical polymerization to enhance its stability and efficacy in the inflammatory environment of periodontal tissues. The PAAM polymer shell serves as a protective barrier to isolate CAT from interactions with proteolytic enzymes and inflammatory mediators in the periodontal microenvironment, thereby preventing structural denaturation and enhancing enzymatic stability. This approach targets the reduction of ROS levels and the modulation of the Nrf‐2/HO‐1 antioxidant pathway, key mediators in oxidative stress responses. In vitro and in vivo studies demonstrated that CAT NPs significantly alleviate oxidative stress, reduce pro‐inflammatory cytokines, and promote periodontal tissue regeneration. Compared to conventional treatments, CAT NPs exhibit superior therapeutic outcomes, offering a promising and long‐lasting solution for the treatment of periodontitis. This innovative strategy provides new avenues for the development of more effective periodontitis therapies.https://doi.org/10.1002/mame.202500022catalasenanoparticlesperiodontitissurface radical polymerization |
| spellingShingle | Tongtong Yan Xiang Li Shiqun Sun Yuchao Luo Haotian Shi Nan Yang Xue Ren Wenjing Tian Zhihui Liu Bin Xu Catalase‐Encapsulated Nanoparticles via Surface Radical Polymerization for Periodontitis Therapy Macromolecular Materials and Engineering catalase nanoparticles periodontitis surface radical polymerization |
| title | Catalase‐Encapsulated Nanoparticles via Surface Radical Polymerization for Periodontitis Therapy |
| title_full | Catalase‐Encapsulated Nanoparticles via Surface Radical Polymerization for Periodontitis Therapy |
| title_fullStr | Catalase‐Encapsulated Nanoparticles via Surface Radical Polymerization for Periodontitis Therapy |
| title_full_unstemmed | Catalase‐Encapsulated Nanoparticles via Surface Radical Polymerization for Periodontitis Therapy |
| title_short | Catalase‐Encapsulated Nanoparticles via Surface Radical Polymerization for Periodontitis Therapy |
| title_sort | catalase encapsulated nanoparticles via surface radical polymerization for periodontitis therapy |
| topic | catalase nanoparticles periodontitis surface radical polymerization |
| url | https://doi.org/10.1002/mame.202500022 |
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